Skip Navigation
Skip to contents
Results by Year

View Wide

Filter

ARTICLE TYPE

PUBLICATION DATE

30 results
Display

Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression

Li G, Liu K, Du X

PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish

Kim CW, Han JH, Wu L, Choi JY

PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
14-3-3ζ Overexpression is Associated with Poor Prognosis in Ovarian Cancer

Kim HJ, Sung SH, Kim CY, Bae MK, Cho MS, Kim YH, Kim SC, Ju W

PURPOSE: 14-3-3ζ regulates cell signaling, cell cycle progression, and apoptosis, and its overexpression is associated with disease recurrence and poor clinical outcomes in some solid tumors. However, its clinicopathological role...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling

Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M

PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes

Park AJ, Agak GW, Qin M, Hisaw LD, Pirouz A, Kao S, Marinelli , Garbán HJ, Thiboutot , Liu PT, Kim J

BACKGROUND: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition

Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK

BACKGROUND/AIMS: The role of Elk-3 in the epithelial-mesenchymal transition (EMT) during liver fibrogenesis remains unclear. Here, we determined the expression of Elk-3 in in vitro and in vivo models and...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1

Song MK, Lee ZH, Kim HH

Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells

Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I

An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene....
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes

Kim SJ, Hur JH, Park C, Kim HJ, Oh GS, Lee JN, Yoo SJ, Choe SK, So HS, Lim DJ, Moon SK, Park R

Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Activation of KRAS promotes the mesenchymal features of basal-type breast cancer

Kim RK, Suh Y, Yoo KC, Cui YH, Kim H, Kim MJ, Kim IG, Lee SJ

Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells

Kim BS, Kang HJ, Park JY, Lee J

Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells

Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH

Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells

Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M

PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells

Liu T, Lee SY

  • KMID: 2154235
  • Exp Mol Med.
  • 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells

Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ

PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma

Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW

  • KMID: 2154222
  • Exp Mol Med.
  • 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-kappaB-dependent cFLIP expression in HeLa cells

Seo OW, Kim JH, Lee KS, Lee KS, Kim JH, Won MH, Ha KS, Kwon YG, Kim YM

  • KMID: 1401757
  • Exp Mol Med.
  • 2012 Nov;44(11):653-664.
This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism. A low dose of kurarinone had...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice

Shin W, Berkowitz , Ryoo S

  • KMID: 1506223
  • Exp Mol Med.
  • 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
The Functional Analysis of MLKs-JNK Pathways in Osteoclast Formation

Ji SY, Ting Z, Noh AL, Moon M, Yim M

OBJECTIVES: Osteoclasts (OCs) are bone-resorbing multinucleated cells derived from hematopoietic progenitors of the monocyte-macrophage lineage. OC precursors, such as bone marrow-derived macrophages (BMMs), are formed in the presence of macrophage...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close
Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells

Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW

Cancer stem cells (CSCs) are resistant to chemo- and radio-therapy, and can survive to regenerate new tumors. This is an important reason why various anti-cancer therapies often fail to completely...
CITED
export Copy
Close
SHARE
Twitter Facebook
Close

Go to Top

Copyright © 2023 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr