- Gene Knockdown in the Olfactory Bulb, Amygdala, and Hypothalamus by Intranasal siRNA Administration
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Kim ID, Kim SW, Lee JK
- KMID: 1472480
- Korean J Anat.
- 2009 Dec;42(4):285-292.
Intranasal administration provides a method of bypassing the blood brain barrier, which separates the systemic circulating system and central interstitial fluid, and directly delivering drugs to the central nervous system.... -
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- Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression
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Li G, Liu K, Du X
- KMID: 2418785
- Yonsei Med J.
- 2018 Mar;59(2):226-235.
- doi: 10.3349/ymj.2018.59.2.226
PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles... -
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- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
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Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
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- p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
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Chae HD, Kim SY, Park SE, Kim J, Shin DY
- KMID: 1245266
- Exp Mol Med.
- 2012 Mar;44(3):236-240.
- doi: 10.3858/emm.2012.44.3.018
We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin... -
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- Role of Caveolin-1 in Indomethacin-induced Death of Human Hepatoadenocarcinoma SK-Hep1 Cells
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Kim KN, Kang JH, Yim SV, Park CS
- KMID: 1838351
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):143-148.
- doi: 10.4196/kjpp.2008.12.4.143
Caveolin-1 (CAV1) is an integral membrane protein that may function as a scaffold for plasma membrane proteins and acts as a tumor suppressor protein. One causative factor of chemotherapy- resistant... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses
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Lee SY, Kim B, Yoon S, Kim YJ, Liu T, Woo JH, Chwae YJ, Joe EH, Jou I
- KMID: 983958
- Exp Mol Med.
- 2010 Sep;42(9):662-673.
- doi: 10.3858/emm.2010.42.9.066
In brain tissue, astrocytes play defensive roles in central nervous system integrity by mediating immune responses against pathological conditions. Type I phosphatidylinositol 4-phosphate 5-kinase alpha (PIP5Kalpha) that is responsible for... -
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- Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
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Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW
- KMID: 1365902
- Exp Mol Med.
- 2012 Apr;44(4):251-259.
- doi: 10.3858/emm.2012.44.4.019
Cancer stem cells (CSCs) are resistant to chemo- and radio-therapy, and can survive to regenerate new tumors. This is an important reason why various anti-cancer therapies often fail to completely... -
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- G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes
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Park AJ, Agak GW, Qin M, Hisaw LD, Pirouz A, Kao S, Marinelli , Garbán HJ, Thiboutot , Liu PT, Kim J
- KMID: 2395175
- Ann Dermatol.
- 2017 Dec;29(6):688-698.
- doi: 10.5021/ad.2017.29.6.688
BACKGROUND: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by... -
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- Calpains are Involved in Entamoeba histolytica-Induced Death of HT-29 Colonic Epithelial Cells
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Jang YS, Song KJ, Kim JY, Lee YA, Kim KA, Lee SK, Shin MH
- KMID: 1090619
- Korean J Parasitol.
- 2011 Jun;49(2):177-180.
- doi: 10.3347/kjp.2011.49.2.177
Entamoeba histolytica is an enteric tissue-invading protozoan parasite that can cause amebic colitis and liver abscess in humans. E. histolytica has the capability to kill colon epithelial cells in vitro;... -
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- Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice
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Minai-Tehrani A, Park YC, Hwang SK, Kwon JT, Chang SH, Park SJ, Yu KN, Kim JE, Shin JY, Kim JH, Kang B, Hong SH, Cho MH
- KMID: 1365013
- J Vet Sci.
- 2011 Dec;12(4):309-317.
- doi: 10.4142/jvs.2011.12.4.309
Conventional lung cancer therapies are associated with poor survival rates; therefore, new approaches such as gene therapy are required for treating cancer. Gene therapies for treating lung cancer patients can... -
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- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
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Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ
- KMID: 1503899
- Yonsei Med J.
- 2013 Mar;54(2):374-380.
- doi: 10.3349/ymj.2013.54.2.374
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated... -
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- TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling
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Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M
- KMID: 2418847
- Yonsei Med J.
- 2018 Jan;59(1):43-50.
- doi: 10.3349/ymj.2018.59.1.43
PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple... -
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- LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
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Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M
- KMID: 1799481
- Yonsei Med J.
- 2014 Sep;55(5):1196-1205.
- doi: 10.3349/ymj.2014.55.5.1196
PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a... -
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- Effects of the knockdown of hypoxia inducible factor-1alpha expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines
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Choi SH, Shin HW, Park JY, Yoo JY, Kim DY, Ro WS, Yun CO, Han KH
- KMID: 1717322
- Korean J Hepatol.
- 2010 Sep;16(3):280-287.
- doi: 10.3350/kjhep.2010.16.3.280
BACKGROUND/AIMS: Hypoxia-inducible factor-1alpha (HIF-1alpha) is a central transcriptional factor involved in the cellular responses related to various aspects of cancer biology, including proliferation, survival, and angiogenesis, and the metabolism of... -
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- The Functional Analysis of MLKs-JNK Pathways in Osteoclast Formation
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Ji SY, Ting Z, Noh AL, Moon M, Yim M
- KMID: 1464232
- Korean J Bone Metab.
- 2012 May;19(1):21-28.
- doi: 10.11005/kjbm.2012.19.1.21
OBJECTIVES: Osteoclasts (OCs) are bone-resorbing multinucleated cells derived from hematopoietic progenitors of the monocyte-macrophage lineage. OC precursors, such as bone marrow-derived macrophages (BMMs), are formed in the presence of macrophage... -
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- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
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Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
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- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
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Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
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Liu T, Lee SY
- KMID: 2154235
- Exp Mol Med.
- 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many... -
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- Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7 cells
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Nguyen TL, Kim CK, Cho JH, Lee KH, Ahn JY
- KMID: 1104385
- Exp Mol Med.
- 2010 Aug;42(8):583-595.
- doi: 10.3858/emm.2010.42.8.060
Neurotrophins protect neurons against excitotoxicity; however the signaling mechanisms for this protection remain to be fully elucidated. Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway... -
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