- Long Non-Coding RNA TUG1 Promotes Proliferation and Inhibits Apoptosis of Osteosarcoma Cells by Sponging miR-132-3p and Upregulating SOX4 Expression
-
Li G, Liu K, Du X
- KMID: 2418785
- Yonsei Med J.
- 2018 Mar;59(2):226-235.
- doi: 10.3349/ymj.2018.59.2.226
PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles... -
- CITED
-
- Close
- SHARE
-
- Close
- microRNA-183 is Essential for Hair Cell Regeneration after Neomycin Injury in Zebrafish
-
Kim CW, Han JH, Wu L, Choi JY
- KMID: 2418861
- Yonsei Med J.
- 2018 Jan;59(1):141-147.
- doi: 10.3349/ymj.2018.59.1.141
PURPOSE: microRNAs (miRNAs) are non-coding RNAs composed of 20 to 22 nucleotides that regulate development and differentiation in various organs by silencing specific RNAs and regulating gene expression. In the... -
- CITED
-
- Close
- SHARE
-
- Close
- 14-3-3ζ Overexpression is Associated with Poor Prognosis in Ovarian Cancer
-
Kim HJ, Sung SH, Kim CY, Bae MK, Cho MS, Kim YH, Kim SC, Ju W
- KMID: 2418848
- Yonsei Med J.
- 2018 Jan;59(1):51-56.
- doi: 10.3349/ymj.2018.59.1.51
PURPOSE: 14-3-3ζ regulates cell signaling, cell cycle progression, and apoptosis, and its overexpression is associated with disease recurrence and poor clinical outcomes in some solid tumors. However, its clinicopathological role... -
- CITED
-
- Close
- SHARE
-
- Close
- TRIM56 Suppresses Multiple Myeloma Progression by Activating TLR3/TRIF Signaling
-
Chen Y, Zhao J, Li D, Hao J, He P, Wang H, Zhang M
- KMID: 2418847
- Yonsei Med J.
- 2018 Jan;59(1):43-50.
- doi: 10.3349/ymj.2018.59.1.43
PURPOSE: Tripartite-motif-containing protein 56 (TRIM56) has been found to exhibit a broad antiviral activity, depending upon E3 ligase activity. Here, we attempted to evaluate the function of TRIM56 in multiple... -
- CITED
-
- Close
- SHARE
-
- Close
- G2A Attenuates Propionibacterium acnes Induction of Inflammatory Cytokines in Human Monocytes
-
Park AJ, Agak GW, Qin M, Hisaw LD, Pirouz A, Kao S, Marinelli , Garbán HJ, Thiboutot , Liu PT, Kim J
- KMID: 2395175
- Ann Dermatol.
- 2017 Dec;29(6):688-698.
- doi: 10.5021/ad.2017.29.6.688
BACKGROUND: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to Propionibacterium acnes (PA). Here, we explore a possible mechanism by... -
- CITED
-
- Close
- SHARE
-
- Close
- Elk-3 Contributes to the Progression of Liver Fibrosis by Regulating the Epithelial-Mesenchymal Transition
-
Li TZ, Kim SM, Hur W, Choi JE, Kim JH, Hong SW, Lee EB, Lee JH, Yoon SK
- KMID: 2412161
- Gut Liver.
- 2017 Jan;11(1):102-111.
- doi: 10.5009/gnl15566
BACKGROUND/AIMS: The role of Elk-3 in the epithelial-mesenchymal transition (EMT) during liver fibrogenesis remains unclear. Here, we determined the expression of Elk-3 in in vitro and in vivo models and... -
- CITED
-
- Close
- SHARE
-
- Close
- Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
-
Song MK, Lee ZH, Kim HH
- KMID: 2359886
- Exp Mol Med.
- 2015 Dec;47(12):e199.
- doi: 10.1038/emm.2015.94
Adseverin is a Ca2+-dependent actin filament-severing protein that has been reported to regulate exocytosis via rearrangements of the actin cytoskeleton in secretory cells. However, the role of adseverin in bone... -
- CITED
-
- Close
- SHARE
-
- Close
- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
-
Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
- CITED
-
- Close
- SHARE
-
- Close
- Bucillamine prevents cisplatin-induced ototoxicity through induction of glutathione and antioxidant genes
-
Kim SJ, Hur JH, Park C, Kim HJ, Oh GS, Lee JN, Yoo SJ, Choe SK, So HS, Lim DJ, Moon SK, Park R
- KMID: 2155407
- Exp Mol Med.
- 2015 Feb;47(2):e142.
- doi: 10.1038/emm.2014.112
Bucillamine is used for the treatment of rheumatoid arthritis. This study investigated the protective effects of bucillamine against cisplatin-induced damage in auditory cells, the organ of Corti from postnatal rats... -
- CITED
-
- Close
- SHARE
-
- Close
- Activation of KRAS promotes the mesenchymal features of basal-type breast cancer
-
Kim RK, Suh Y, Yoo KC, Cui YH, Kim H, Kim MJ, Kim IG, Lee SJ
- KMID: 2155402
- Exp Mol Med.
- 2015 Jan;47(1):e137.
- doi: 10.1038/emm.2014.99
Basal-type breast cancers are among the most aggressive and deadly breast cancer subtypes, displaying a high metastatic ability associated with mesenchymal features. However, the molecular mechanisms underlying the maintenance of... -
- CITED
-
- Close
- SHARE
-
- Close
- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
-
Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
- CITED
-
- Close
- SHARE
-
- Close
- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
-
Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
- CITED
-
- Close
- SHARE
-
- Close
- LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
-
Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M
- KMID: 1799481
- Yonsei Med J.
- 2014 Sep;55(5):1196-1205.
- doi: 10.3349/ymj.2014.55.5.1196
PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a... -
- CITED
-
- Close
- SHARE
-
- Close
- Phosphatidylinositol 4-phosphate 5-kinase alpha negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells
-
Liu T, Lee SY
- KMID: 2154235
- Exp Mol Med.
- 2013 Mar;45(3):e16.
Neurite outgrowth, a cell differentiation process involving membrane morphological changes, is critical for neuronal network and development. The membrane lipid, phosphatidylinositol (PI) 4,5-bisphosphate (PIP2), is a key regulator of many... -
- CITED
-
- Close
- SHARE
-
- Close
- Blockade of VEGFR-1 and VEGFR-2 Enhances Paclitaxel Sensitivity in Gastric Cancer Cells
-
Hwang JE, Lee JH, Park MR, Kim DE, Bae WK, Shim HJ, Cho SH, Chung IJ
- KMID: 1503899
- Yonsei Med J.
- 2013 Mar;54(2):374-380.
- doi: 10.3349/ymj.2013.54.2.374
PURPOSE: Hypoxia-inducible factor-1alpha (HIF-1alpha) increases transcription of the vascular endothelial growth factor (VEGF) gene. Inhibition of VEGF abolishes VEGF mediated induction of HIF-1alpha. Recent reports suggested that HIF-1alpha also mediated... -
- CITED
-
- Close
- SHARE
-
- Close
- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
-
Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
- CITED
-
- Close
- SHARE
-
- Close
- Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-kappaB-dependent cFLIP expression in HeLa cells
-
Seo OW, Kim JH, Lee KS, Lee KS, Kim JH, Won MH, Ha KS, Kwon YG, Kim YM
- KMID: 1401757
- Exp Mol Med.
- 2012 Nov;44(11):653-664.
This study was designed to investigate the effects of the prenylated flavonoid kurarinone on TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis and its underlying mechanism. A low dose of kurarinone had... -
- CITED
-
- Close
- SHARE
-
- Close
- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
-
Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
- CITED
-
- Close
- SHARE
-
- Close
- The Functional Analysis of MLKs-JNK Pathways in Osteoclast Formation
-
Ji SY, Ting Z, Noh AL, Moon M, Yim M
- KMID: 1464232
- Korean J Bone Metab.
- 2012 May;19(1):21-28.
- doi: 10.11005/kjbm.2012.19.1.21
OBJECTIVES: Osteoclasts (OCs) are bone-resorbing multinucleated cells derived from hematopoietic progenitors of the monocyte-macrophage lineage. OC precursors, such as bone marrow-derived macrophages (BMMs), are formed in the presence of macrophage... -
- CITED
-
- Close
- SHARE
-
- Close
- Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
-
Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW
- KMID: 1365902
- Exp Mol Med.
- 2012 Apr;44(4):251-259.
- doi: 10.3858/emm.2012.44.4.019
Cancer stem cells (CSCs) are resistant to chemo- and radio-therapy, and can survive to regenerate new tumors. This is an important reason why various anti-cancer therapies often fail to completely... -
- CITED
-
- Close
- SHARE
-
- Close
