- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
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Ko HS, Park BJ, Choi SK, Kang HK, Kim A, Kim HS, Park IY, Shin JC
- KMID: 2374099
- Yonsei Med J.
- 2016 May;57(3):761-768.
- doi: 10.3349/ymj.2016.57.3.761
PURPOSE: Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells
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Park KS, Jeon SH, Oh JW, Choi KY
- KMID: 1103323
- Exp Mol Med.
- 2004 Dec;36(6):557-562.
p21Cip/WAF1, an important regulator of cell proliferation, is induced by both p53- and extracellular signal regulated kinase (ERK) pathways. The induction of p21Cip/WAF1 occurs by prolonged activation of the ERKs... -
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- Shank 2 expression coincides with neuronal differentiation in the developing retina
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Kim JH, Kim JH, Yang E, Park JH, Yu YS, Kim KW
- KMID: 1088598
- Exp Mol Med.
- 2009 Apr;41(4):236-242.
- doi: 10.3858/emm.2009.41.4.026
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation... -
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- Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages
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Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB
- KMID: 1116203
- Exp Mol Med.
- 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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- Anti-Proliferative and Apoptotic Activities of Mullerian Inhibiting Substance Combined with Calcitriol in Ovarian Cancer Cell Lines
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Jung YS, Kim HJ, Seo SK, Choi YS, Nam EJ, Kim S, Kim SW, Han HD, Kim JW, Kim YT
- KMID: 2466349
- Yonsei Med J.
- 2016 Jan;57(1):33-40.
- doi: 10.3349/ymj.2016.57.1.33
PURPOSE: This study aimed to investigate whether Mullerian inhibiting substance (MIS) in combination with calcitriol modulates proliferation and apoptosis of human ovarian cancer (OCa) cell lines (SKOV3, OVCAR3, and OVCA433)... -
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- Effects of Antioxidant on Reduction of Hindlimb Muscle Atrophy Induced by Cisplatin in Rats
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Kim JI, Choe MA
- KMID: 1791866
- J Korean Acad Nurs.
- 2014 Aug;44(4):371-380.
- doi: 10.4040/jkan.2014.44.4.371
PURPOSE: The purpose of this study was to examine the effects of Cu/Zn SOD on reduction of hindlimb muscular atrophy induced by cisplatin in rats. METHODS: Forty-two rats were assigned to... -
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- Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1
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Lee EG, Yun HJ, Lee SI, Yoo WH
- KMID: 1785661
- Korean J Intern Med.
- 2010 Mar;25(1):93-100.
- doi: 10.3904/kjim.2010.25.1.93
BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation.... -
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- Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
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Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY
- KMID: 2154228
- Exp Mol Med.
- 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the... -
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- The Expression of Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala, Induced by Colorectal Distension, is Attenuated by General Anesthesia
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Kim SH, Han JE, Hwang S, Oh DH
- KMID: 1779236
- J Korean Med Sci.
- 2010 Nov;25(11):1646-1651.
- doi: 10.3346/jkms.2010.25.11.1646
Corticotrophin-releasing factor (CRF), a key regulator of the hypothalamic-pituitary axis, is expressed in the central nucleus of the amygdala (CeA) and its expression is upregulated in stress-related disorders. We investigated... -
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- Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP)
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Schubert T, Schlegel J, Schmid R, Opolka A, Grassel S, Humphries , Bosserhoff AK
- KMID: 946649
- Exp Mol Med.
- 2010 Mar;42(3):166-174.
- doi: 10.3858/emm.2010.42.3.017
Melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) is a small soluble protein secreted from malignant melanoma cells and from chondrocytes. Recently, we revealed that MIA/CD-RAP can modulate bone morphogenetic protein... -
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- Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation
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Lim BJ, Lee D, Hong SW, Jeong HJ
- KMID: 1727993
- Yonsei Med J.
- 2011 Jul;52(4):610-615.
- doi: 10.3349/ymj.2011.52.4.610
PURPOSE: Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We... -
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- Effect of DHEA on Recovery of Muscle Atrophy Induced by Parkinson's Disease
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Choe MA, An GJ, Koo BS, Jeon S
- KMID: 1120116
- J Korean Acad Nurs.
- 2011 Dec;41(6):834-842.
- doi: 10.4040/jkan.2011.41.6.834
PURPOSE: The purpose of this study was to determine the effect of dehydroepiandrosterone (DHEA) on recovery of muscle atrophy induced by Parkinson's disease. METHODS: The rat model was established by direct... -
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- Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy
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Yoon YW, Kang TS, Lee BK, Chang W, Hwang KC, Rhee JH, Min PK, Hong BK, Rim SJ, Kwon HM
- KMID: 1094119
- Exp Mol Med.
- 2008 Aug;40(4):398-406.
- doi: 10.3858/emm.2008.40.4.398
Advanced glycation endproducts (AGEs) have been reported to play a role in neointimal formation and increase the rate of in-stent restenosis (ISR) in the diabetic coronary artery disease patients treated... -
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- Role of gamma-aminobutyric acid B (GABA B) receptors in the regulation of kainic acid-induced cell death in mouse hippocampus
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Lee HK, Seo YJ, Choi SS, Kwon MS, Shim EJ, Lee JY, Suh HW
- KMID: 1116198
- Exp Mol Med.
- 2005 Dec;37(6):533-545.
Kainic acid (KA) is well-known as an excitatory, neurotoxic substance. In mice, KA administered intracerebroventricularly (i.c.v.) lead to morphological damage of hippocampus expecially concentrated on the CA3 pyramidal neurons. In... -
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- Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
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Yun JH, Park SJ, Jo A, Kang JL, Jou I, Park JS, Choi YH
- KMID: 1058703
- Exp Mol Med.
- 2011 Dec;43(12):660-668.
- doi: 10.3858/emm.2011.43.12.075
Recent evidence supports a neuroprotective role of Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) against ischemic brain injury. However, the molecular mechanisms of SHP-2 activation and those governing how... -
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- Could HBx Protein Expression Affect Signal Pathway Inhibition by Gefitinib or Selumetinib, a MEK Inhibitor, in Hepatocellular Carcinoma Cell Lines?
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Park YK, Kim KM, Lee YJ, Kim KH, Lee SG, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS, Suh DJ
- KMID: 1782109
- J Korean Med Sci.
- 2011 Feb;26(2):214-221.
- doi: 10.3346/jkms.2011.26.2.214
Hepatitis B virus X (HBx) protein has been known to play an important role in development of hepatocellular carcinoma (HCC). The aim of this study is to find out whether... -
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- Phytosphingosine-1-phosphate stimulates chemotactic migration of L2071 mouse fibroblasts via pertussis toxin-sensitive G-proteins
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Kim MK, Park KS, Lee H, Kim YD, Yun J, Bae YS
- KMID: 1094659
- Exp Mol Med.
- 2007 Apr;39(2):185-194.
Phytosphingosine-1-phosphate (PhS1P) was found to stimulate an intracellular calcium increase via phospholipase C but not pertussis toxin (PTX)- sensitive G-proteins in L2071 mouse fibroblasts. PhS1P also activated ERK and p38... -
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