- STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9
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Ko HS, Park BJ, Choi SK, Kang HK, Kim A, Kim HS, Park IY, Shin JC
- KMID: 2374099
- Yonsei Med J.
- 2016 May;57(3):761-768.
- doi: 10.3349/ymj.2016.57.3.761
PURPOSE: Our previous studies have shown that oncostatin M (OSM) promotes trophoblast invasion activity through increased enzyme activity of matrix metalloproteinase (MMP)-2 and -9. We further investigated OSM-induced intracellular signaling... -
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- Anti-Proliferative and Apoptotic Activities of Mullerian Inhibiting Substance Combined with Calcitriol in Ovarian Cancer Cell Lines
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Jung YS, Kim HJ, Seo SK, Choi YS, Nam EJ, Kim S, Kim SW, Han HD, Kim JW, Kim YT
- KMID: 2466349
- Yonsei Med J.
- 2016 Jan;57(1):33-40.
- doi: 10.3349/ymj.2016.57.1.33
PURPOSE: This study aimed to investigate whether Mullerian inhibiting substance (MIS) in combination with calcitriol modulates proliferation and apoptosis of human ovarian cancer (OCa) cell lines (SKOV3, OVCAR3, and OVCA433)... -
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- Effects of Antioxidant on Reduction of Hindlimb Muscle Atrophy Induced by Cisplatin in Rats
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Kim JI, Choe MA
- KMID: 1791866
- J Korean Acad Nurs.
- 2014 Aug;44(4):371-380.
- doi: 10.4040/jkan.2014.44.4.371
PURPOSE: The purpose of this study was to examine the effects of Cu/Zn SOD on reduction of hindlimb muscular atrophy induced by cisplatin in rats. METHODS: Forty-two rats were assigned to... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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- Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates
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Lee YJ, Jeong JK, Seol JW, Xue M, Jackson C, Park SY
- KMID: 2154228
- Exp Mol Med.
- 2013 Feb;45(2):e9.
Activated protein C (APC) is a cytoprotective anticoagulant that can promote cutaneous healing. We examined the effect of APC on viability and differentiation of the osteoblastic line, MG63, in the... -
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- Effect of DHEA on Recovery of Muscle Atrophy Induced by Parkinson's Disease
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Choe MA, An GJ, Koo BS, Jeon S
- KMID: 1120116
- J Korean Acad Nurs.
- 2011 Dec;41(6):834-842.
- doi: 10.4040/jkan.2011.41.6.834
PURPOSE: The purpose of this study was to determine the effect of dehydroepiandrosterone (DHEA) on recovery of muscle atrophy induced by Parkinson's disease. METHODS: The rat model was established by direct... -
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- Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes
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Yun JH, Park SJ, Jo A, Kang JL, Jou I, Park JS, Choi YH
- KMID: 1058703
- Exp Mol Med.
- 2011 Dec;43(12):660-668.
- doi: 10.3858/emm.2011.43.12.075
Recent evidence supports a neuroprotective role of Src homology 2-containing protein tyrosine phosphatase 2 (SHP-2) against ischemic brain injury. However, the molecular mechanisms of SHP-2 activation and those governing how... -
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- Sulforaphane Induces Antioxidative and Antiproliferative Responses by Generating Reactive Oxygen Species in Human Bronchial Epithelial BEAS-2B Cells
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Lee YJ, Lee SH
- KMID: 1123448
- J Korean Med Sci.
- 2011 Nov;26(11):1474-1482.
- doi: 10.3346/jkms.2011.26.11.1474
Sulforaphane (SFN) is a naturally occurring compound which is known to induce the phase II antioxidant genes via Nrf2 activation, although the underlying mechanism has not been fully elucidated. In... -
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- Toll-Like Receptor 4 Signaling is Involved in IgA-Stimulated Mesangial Cell Activation
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Lim BJ, Lee D, Hong SW, Jeong HJ
- KMID: 1727993
- Yonsei Med J.
- 2011 Jul;52(4):610-615.
- doi: 10.3349/ymj.2011.52.4.610
PURPOSE: Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We... -
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- Could HBx Protein Expression Affect Signal Pathway Inhibition by Gefitinib or Selumetinib, a MEK Inhibitor, in Hepatocellular Carcinoma Cell Lines?
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Park YK, Kim KM, Lee YJ, Kim KH, Lee SG, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS, Suh DJ
- KMID: 1782109
- J Korean Med Sci.
- 2011 Feb;26(2):214-221.
- doi: 10.3346/jkms.2011.26.2.214
Hepatitis B virus X (HBx) protein has been known to play an important role in development of hepatocellular carcinoma (HCC). The aim of this study is to find out whether... -
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- Low-dose UVB irradiation stimulates matrix metalloproteinase-1 expression via a BLT2-linked pathway in HaCaT cells
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Kim C, Ryu HC, Kim JH
- KMID: 1115267
- Exp Mol Med.
- 2010 Dec;42(12):833-841.
- doi: 10.3858/emm.2010.42.12.086
Skin exposure to low-dose ultraviolet B (UVB) light up-regulates the expression of matrix metalloproteinase-1 (MMP-1), thus contributing to premature skin aging (photo-aging). Although cyclooxygenase-2 (COX-2) and its product, prostaglandin E2... -
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- The Expression of Corticotropin-Releasing Factor in the Central Nucleus of the Amygdala, Induced by Colorectal Distension, is Attenuated by General Anesthesia
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Kim SH, Han JE, Hwang S, Oh DH
- KMID: 1779236
- J Korean Med Sci.
- 2010 Nov;25(11):1646-1651.
- doi: 10.3346/jkms.2010.25.11.1646
Corticotrophin-releasing factor (CRF), a key regulator of the hypothalamic-pituitary axis, is expressed in the central nucleus of the amygdala (CeA) and its expression is upregulated in stress-related disorders. We investigated... -
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- A serum-stable branched dimeric anti-VEGF peptide blocks tumor growth via anti-angiogenic activity
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Kim JW, Kim TD, Hong BS, Kim OY, Yoon WH, Chae CB, Gho YS
- KMID: 1104211
- Exp Mol Med.
- 2010 Jul;42(7):514-523.
- doi: 10.3858/emm.2010.42.7.052
Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for... -
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- Ethyl Acetate Fraction from Cudrania Tricuspidata Inhibits IL-1beta-Stimulated Osteoclast Differentiation through Downregulation of MAPKs, c-Fos and NFATc1
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Lee EG, Yun HJ, Lee SI, Yoo WH
- KMID: 1785661
- Korean J Intern Med.
- 2010 Mar;25(1):93-100.
- doi: 10.3904/kjim.2010.25.1.93
BACKGROUND/AIMS: The present study was performed to determine the effects of the ethyl acetate extract of Cudrania tricuspidata (EACT) on interleukin (IL)-1beta-stimulated receptor activator of NF-kappaB ligand (RANKL)-mediated osteoclast differentiation.... -
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- Modulation of cartilage differentiation by melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP)
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Schubert T, Schlegel J, Schmid R, Opolka A, Grassel S, Humphries , Bosserhoff AK
- KMID: 946649
- Exp Mol Med.
- 2010 Mar;42(3):166-174.
- doi: 10.3858/emm.2010.42.3.017
Melanoma inhibiting activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) is a small soluble protein secreted from malignant melanoma cells and from chondrocytes. Recently, we revealed that MIA/CD-RAP can modulate bone morphogenetic protein... -
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- Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract
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Kim SE, Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS
- KMID: 1088603
- Exp Mol Med.
- 2009 Apr;41(4):277-287.
- doi: 10.3858/emm.2009.41.4.031
Matrix metalloproteinase-9 (MMP-9) may play an important role in emphysematous change in chronic obstructive pulmonary disease (COPD), one of the leading causes of mortality and morbidity worldwide. We previously reported... -
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- Shank 2 expression coincides with neuronal differentiation in the developing retina
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Kim JH, Kim JH, Yang E, Park JH, Yu YS, Kim KW
- KMID: 1088598
- Exp Mol Med.
- 2009 Apr;41(4):236-242.
- doi: 10.3858/emm.2009.41.4.026
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation... -
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- Aldosterone-induced TGF-beta1 Expression is Regulated by Mitogen-Activated Protein Kinases and Activator Protein-1 in Mesangial Cells
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Han JS, Cho BS, Yang CW, Kim YS
- KMID: 1778162
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S195-S203.
- doi: 10.3346/jkms.2009.24.S1.S195
Aldosterone has been shown to stimulate renal TGF-beta1 expression. However, the mechanisms for aldosterone-induced TGF-beta1 expression have not been clearly determined in mesangial cells. We examined the role of extracellular-signal... -
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- Thromboxane A2 modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells
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Yun DH, Song HY, Lee MJ, Kim MR, Kim MY, Lee JS, Kim JH
- KMID: 756282
- Exp Mol Med.
- 2009 Jan;41(1):17-24.
- doi: 10.3858/emm.2009.41.1.003
Prostanoid metabolites are key mediators in inflammatory responses, and accumulating evidence suggests that mesenchymal stem cells (MSCs) can be recruited to injured or inflamed tissues. In the present study, we... -
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