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Water Intoxication Following Low-Dose Intravenous Cyclophosphamide

Koo TY, Bae SC, Park JS, Lee CH, Park MH, Kang CM, Kim GH

Cyclophosphamide is frequently used for the treatment of severe lupus nephritis, but is very rarely associated with dilutional hyponatremia. Recently we experienced a case of water intoxication following low-dose intravenous...
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SIADH Associated with Prostate Cancer

Lee KS, Kang TW, Ma SK, Kim SW, Kim NH, Choi KC

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common disease leading to hyponatremia, and it is characterized by an inappropriately elevated serum ADH level relative to serum osmolality....
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Metabolic Acidosis in Maintenance Hemodialysis Patients: Clinical Impact and Intervention

Kim HJ, Han SW

Metabolic acidosis has been considered as one of the reverse epidemiologic factors for the morbidity and mortality in maintenance hemodialysis patients (MHP). Expectedly, in the recent large scale epidemiologic study...
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Hypertensive Hypokalemic Disorders

Choi KB

Hypokalemia is a common clinical problem. The kidney is responsible for long term potassium homoeostasis, as well as the serum potassium concentration. The main nephron site where K secretion is...
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Regulation of Urea Transporters by Tonicity-responsive Enhancer Binding Protein

Jung JY, Kwon M, Kim J

Urea accumulation in the renal inner medulla plays a key role in the maintenance of maximal urinary concentrating ability. Urea transport in the kidney is mediated by transporter proteins that...
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Effects of Antioxidant Drugs in Rats with Acute Renal Injury

Bae EH, Lee JU, Kim SW

Acute renal failure is mainly caused by ischemia/reperfusion (I/R) injury or nephrotoxic drugs, in which reactive oxygen species (ROS) may play an important role. Therefore, antioxidants are expected to decrease...
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Regulation of AQP2 in Collecting Duct: An emphasis on the Effects of Angiotensin II or Aldosterone

Lee BH, Kwon TH

Vasopressin, angiotensin II (AngII), and aldosterone are essential hormones in the regulation of body fluid homeostatsis. We examined the effects of AngII or aldosterone on the regulation of body water...
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Changes in Urine Osmolar Composition seen in Different Age Groups in the Local Korean Population

Lee KH, Kang KP, Kim MS, Lee DY, Kang SK

Due to their unique living conditions and dietary habits, the Koreans' renal function model may be different from that of the Western people. About 40 years ago, a researcher reported...
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Clinical Significance of Strong Ion Gap: between ICU and Hemodialysis Patients with Metabolic Acidosis

Lee YS

Metabolic acidosis is the most frequent acid-base disorder in critically ill patients and dialysis patients. This study is to compare the conventional approach with the physicochemical approach between the intensive...
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