Electrolyte Blood Press.  2007 Jun;5(1):50-54. 10.5049/EBP.2007.5.1.50.

Water Intoxication Following Low-Dose Intravenous Cyclophosphamide

• Koo TY
• Bae SC
• Park JS
• Lee CH
• Park MH
• Kang CM
• Kim GH

• KMID: 2134806
• DOI: http://doi.org/10.5049/EBP.2007.5.1.50

Abstract

Cyclophosphamide is frequently used for the treatment of severe lupus nephritis, but is very rarely associated with dilutional hyponatremia. Recently we experienced a case of water intoxication following low-dose intravenous cyclophosphamide. Five hours after one dose of intravenous pulse cyclophosphamide 750 mg, the patient developed nausea, vomiting, and general weakness. Serum sodium concentration revealed 114 mEq/L and her hyponatremia was initially treated with hypertonic saline infusion. Then her serum sodium concentration rapidly recovered to normal with water restriction alone. During the course of intravenous pulse cyclophosphamide therapy, one must be aware of the possibility of significant water retention.

MeSH Terms

Cyclophosphamide*
Humans
Hyponatremia
Lupus Nephritis
Nausea
Sodium
Vomiting
Water Intoxication*
Cyclophosphamide
Sodium
Water Intoxication*

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