J Korean Rheum Assoc.
1996 Jul;3(2):187-194.
Effect of Cyclophospharmide Pulse and Combined with Per Oral Low Dose Glucorticoid on Pulmonary Fibrosis in Patient with Sistemic Sclerosis
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
Abstract
OBJECTIVE
To investigate the efficacy of combined intravenous cyclophophamide pulse and low dose oral prednisolone treatment in patients with systemic sclerosis with -interstitial lung disease. METHOD: Six patients with systemic sclerosis with interstitial lung disease were treated with intravenous infusion of cyclophosphamide(0. 75g/m2 body surface area) and low dose oral prednisolone (10mg/day).
RESULTS
1) Respiratory symptoms, cough and dyspnea, were improved in all patients in both frequency and severity. 2) The mean value of FVC, FEV1, and DLC test showed tendency of increase during the follow up period (upto 24 months) compared to decrease in the past studies. 3)There was no serious side effect during the trreatment. Herpes zoster was developede in I patient during treament.
CONCLUSIONS
Combined intravenous cyclophosphamide pulse and low dose oral prednisolone treatment is effective for the patients with systemic sclerosis with interstitial lung disease. A controlled prospective trial is warranted in patients with systemic sclerosis with interstitial lung disease.
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