Korean J Nephrol.  2011 Nov;30(6):647-650.

Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report

Affiliations
  • 1Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. amp97@yuhs.ac

Abstract

Cyclophosphamide (CY), an alkylating agent, is frequently used in the treatment of various autoimmune disorders and malignancies. Acute hyponatremia is a well-known side effect of moderate to high dose intravenous CY treatment, but is rare in patients treated with low dose intravenous CY. We report the case of a severe symptomatic hyponatremia in a 68-year-old woman with renal impairment who was treated with oral CY (100 mg/day) for anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN). This case demonstrates that even oral CY could be associated with life threatening acute hyponatremia and should be used with caution.

Keyword

Hyponatremia; Cyclophosphamide; ANCA associated vasculitis

MeSH Terms

Aged
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
Female
Glomerulonephritis
Humans
Hyponatremia
Antibodies, Antineutrophil Cytoplasmic
Cyclophosphamide
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