J Breast Cancer.  2011 Dec;14(4):345-348. 10.4048/jbc.2011.14.4.345.

Life-Threatening Acute Hyponatremia with Generalized Seizure Induced by Low-Dose Cyclophosphamide in a Patient with Breast Cancer

• Hwang SB
• Lee HY
• Kim HY
• Lee ES
• Bae JW

• KMID: 2175740
• DOI: http://doi.org/10.4048/jbc.2011.14.4.345

Abstract

Cyclophosphamide is commonly used in the treatment of malignant diseases. Symptomatic severe hyponatremia induced by low-dose cyclophosphamide is very uncommon worldwide. Recently we experienced a case of a 56-year-old woman with breast cancer who developed severe hyponatremia with generalized seizure after the first cycle of adjuvant chemotherapy with doxorubicin and cyclophosphamide. Her laboratory test showed a serum sodium of 116 mmol/L. Her hyponatremia was initially treated with hypertonic saline solution and furosemide. She completely recovered without neurological deficits after slow correction of the serum sodium concentration over two days. Clinicians must always keep in mind that life-threatening acute hyponatremia can be induced by intravenous cyclophosphamide during chemotherapy, even if the dosage is low.

Keyword

Breast neoplasms; Cyclophosphamide; Hyponatremia; Seizures

MeSH Terms

Breast
Breast Neoplasms
Chemotherapy, Adjuvant
Cyclophosphamide
Doxorubicin
Female
Furosemide
Humans
Hyponatremia
Middle Aged
Saline Solution, Hypertonic
Seizures
Sodium
Cyclophosphamide
Doxorubicin
Furosemide
Saline Solution, Hypertonic
Sodium

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