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Comparison of Edrophonium and Neostigmine for reversal of the effects of Vecuronium

Kim SY, Kim SI, Hwang KH

Until recently edrophonium has not been used in clinical anesthesis because of its short duration of action and poor anticholinesterase activity. However there has been a renewed interest in the...
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Effects of Edrophonium and/or Pseudocholinesterase for the Reversal of Mivacurium-Induced Paralysis in vitro

Park DH, Seong KW, Jeong WY, Kim HK, Yang HS

BACKGROUND: Mivacurium is a nondepolarizing neuromuscular blocking agent hydrolyzed by pseudocholinesterase. Anticholinesterase used in the reversal of mivacurium-induced muscle relaxation may also inhibit plasma pseudocholinesterase, and delay hydrolysis...
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Reversal Effects of Neostigmine, Edrophonium and 4-aminopyridine of Verapamil Pretreatment on Pipecuronium Induced Neuromuscular Blockade in Rat-Hemidiaphragm

Park JW, Yoon SM

BACKGROUND: It has been shown that L-type calcium channel blockers increase the muscle relaxation effects of non-depolarizing neuromuscular blocking agents whereas the potentiated neuromuscular blocking effects by L-type calcium channel...
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The Antiallodynic Effect of Edrophonium and Neostigmine in a Neuropathic Pain Model

Hwang JH, Ham KD, Lee DM

BACKGROUND: Peripheral nerve injury may produce a syndrome consisting of spontaneous pain, allodynia and hyperpathia. Cholinesterase inhibitors are known to have an antinociceptive effect in hot plate and tail flick...
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The Effect of 4-Aminopyridine with Anticholinesterases on MgSO4-Rocuronium-Induced Neuromuscular Blockade in Vitro

Hwang KH, Cho MH, Hong ST, Park W, Kim SY

BACKGROUND: The aim of this study was to evaluate the effect of 4-aminopyridine (4-AP) combined with anticholiesterase (antiChE) in antagonizing MgSO4-rocuronium-induced neuromuscualr blockade using a rat hemidiaphragm. METHODS: A hemidiaphragm with...
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The Usefulness of Ice Test for Diagnosis of Myasthenia Gravis in Patients with Ptosis

Hwang SJ, Lee TS, Park BW

  • KMID: 2207930
  • J Korean Ophthalmol Soc.
  • 2005 Oct;46(10):1611-1617.
PURPOSE: To compare the results of the ice test with other diagnostic tests for the diagnosis of myasthenia gravis in patients with ptosis. METHODS: The patients included in this study...
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Neuromuscular Block by Vecuronium and its Reversal with Pyridostigmine in Rabbits

Kim KH, Lee DH, Kim KS, Suh JK, Yoo HK, Seung IS, Chon SU

Despite the fact that the anticholinesterases, mainly neostigmine, has been used for many years to antagonize a nondepolarizing neuromuscular blockade, until recently nothing was known about their pharmacokinetics and dynamics...
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House-Hold Myasthenic Syndrome

Han DK, Choi SK, SONG JE

  • KMID: 1675875
  • J Korean Ophthalmol Soc.
  • 1967 Dec;8(3):31-36.
We have recently seen a myasthenic syndrome occurring in a mother, four out of five children, a young woman of non-blood relative. All developed this disease between April and June,...
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Myasthenia Gravis-Anesthetic Experience with - Two Cases

Shin KI, Kwak IY, Kim KW, Chung CK

  • KMID: 2358203
  • Korean J Anesthesiol.
  • 1970 Jan;3(1):39-44.
Anesthetic experience with thymectomies for two patients with myasthenia gravis has been reported. Both of them talerated the surgical procedures under endotracheal nitrous oxide-oxygen-halothane anesthesia well, but one of tbem...
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Effects of Neostigmine , Pyridostigmine and Edrophonium on Plasma Cholinesterase Activity and Train-of-four Response

Kim SC, Hwang KH, Kim SY

Effects of the anticholinesterase drugs on plasma cholinesterase activity, plasma albumin level and train-of-four response were investigated in 38 ASA class 1 or 2 adult patients undergoing elective surgery. Anesthesia...
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The Antinociceptive Effect of Intrathecal Anticholinesterase on the Formalin Test in Rats

Jung G, Yoon MH, Jeong SW, Kwak SH, Chung SS, Jeong CY

BACKGROUND: Spinal anticholinesterase has been shown to have an antinociceptive action to acute noxious stimuli. The purpose of this study was to determine the effect of intrathecal anticholinesterase on the...
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Two Cases of Myasthenia Gravis Showing Fatigibility Presenting with Decreased Gain of Smooth Pursuit

Chae JH, Shin HJ, Shin BS, Seo MW, Oh SY

Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies to the acetylcholine receptors of the neuromuscular junction characterized by weakness and abnormal fatigability of the muscles. Therefore, the diagnosis...
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A Patient with Coexisting Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

Kim JA, Lim YM, Jang EH, Kim KK

BACKGROUND: The coexistence of myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) is very rare and remains controversial. CASE REPORT: A 48-year-old woman initially presented with noticeable right ptosis and intermittent...
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The Effect of Selective Muscarinic Receptor Antagonists on Antiallodynic Action in a Rat Model of Neuropathic Pain

Hwang JH, Shim HR, Hwang KS

BACKGROUND: Peripheral nerve injury may produce a syndrome consisting of spontaneous pain, allodynia and hyperpathia. In previous study, we examined the antiallodynic action produced by intrathecal (i.t.) cholinesterase inhibitors (ChEi)...
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Tensilon Tonometry in Diagnosis of Myasthenia Gravis

Shin DJ, Song HK, Kim JH, Chung KC, Kim MH, Park IW, Choe JK

  • KMID: 1957530
  • J Korean Neurol Assoc.
  • 1988 Dec;6(2):186-190.
There are many reports which show that contraction of the extraocular muscles results in an increase in intraocular pressure(IOP). Goldmann tonometer was used to record IOP after Tensilon injection in...
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Effects of Pseudocholinesterase and/or Neostigmine, Pyridostigmine, Edrophonium and Galanthamine for Reversal of Mivacurium- or Succinylcholine-induced Paralysis in Vitro

Cho SS, Yoon SN, Choi Y, Yang HS, Han SM, Kim SY, Suh BT

BACKGROUND: The hydrolysis of mivacurium and succinylcholine is impaired in the presence of defects of pseudocholinesterase. Clinical reports are conflicting as to the utility of anticholinesterases, in the reversal of...
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Muscle-Specific Receptor Tyrosine Kinase Antibody Positive Myasthenia Gravis Current Status

Oh SJ

Muscle-specific tyrosine-kinase-antibody-positive myasthenia gravis (MuSK-MG) has emerged as a distinct entity since 2001. This disease has been reported worldwide, but with varying rates among patients with generalized acetylcholine-receptor-antibody-negative MG. MuSK-MG...
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Findings of repetitive nerve stimulation test in myasthenia gravis: A case-control study

Kim DS, Kim SH, Lee SI, Song CW, Park KH, Kim SW

  • KMID: 2016083
  • J Korean Neurol Assoc.
  • 1991 Mar;9(1):57-65.
Authors had perforrned repetitive nerve stimulation tests on orbicularis oculi, flexor carpi ulnaris, and abductor digiti quinti muscles in 21 myasthenic patients and 40 normal controls using conventional Oh's rnethod...
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Efficacy of Gaze Photographs in Diagnosing Ocular Myasthenia Gravis

Ahn J, Park KS, Kim JS, Hwang JM

BACKGROUND AND PURPOSE: The various tests that are routinely used to diagnose generalized myasthenia gravis, such as the edrophonium test, serum anti-acetylcholine-receptor antibodies (AChR-Ab), and repetitive nerve stimulation (RNS) tests,...
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Bulbar Myasthenia Gravis Superimposed in a Medullary Infarction Diagnosed by a Fiberoptic Endoscopic Evaluation of Swallowing With Simultaneous Tensilon Application

Kim SJ, Park GY, Choi YM, Sohn DG, Kang SR, Im S

In the elderly, myasthenia gravis (MG) can present with bulbar symptoms, which can be clinically difficult to diagnose from other neurological comorbid conditions. We describe a case of a 75-year-old...
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