Korean J Anesthesiol.  1988 Apr;21(2):307-312. 10.4097/kjae.1988.21.2.307.

Neuromuscular Block by Vecuronium and its Reversal with Pyridostigmine in Rabbits

• Kim KH
• Lee DH
• Kim KS
• Suh JK
• Yoo HK
• Seung IS
• Chon SU

• KMID: 1933173
• DOI: http://doi.org/10.4097/kjae.1988.21.2.307

Abstract

Despite the fact that the anticholinesterases, mainly neostigmine, has been used for many years to antagonize a nondepolarizing neuromuscular blockade, until recently nothing was known about their pharmacokinetics and dynamics in anesthetized patients. This deficiency was largely due to lack of a suitable analytic technique to measure the concentration of these drugs in body fluids, most importantly serum. Recently it was developed a method by which the serum concentrations of neostigmine, pyridostigmine, edrophonium and their metabolities can be measured. Recently,k pyridostigmine and edrophonium have gained popularity to use for reversing a nondepolarizing muscle relaxants. We have studied newly introduced vecuronium effects and its reversal with pyridostigmine. The results were as follows: 1) Spontaneous recovery index by vecuronium 0.1mg/kg was 620.8 sec. 2) Recovery index by the pyridostigmine 160ug/kg reversal was significantly shortened as 134.0sec in vecuronium 0.1mg/kg block. 3) Tetanic stimulation (100Hz, 5sec) was sustained after 75% recovery of twitch height by pyridostigmine 160ug/kg reversal.

Keyword

Muscle relaxant; vecuronium; Anticholinesterase; pyridostigmine

MeSH Terms

Body Fluids
Cholinesterase Inhibitors
Edrophonium
Humans
Neostigmine
Neuromuscular Blockade*
Pharmacokinetics
Pyridostigmine Bromide*
Rabbits*
Vecuronium Bromide*
Cholinesterase Inhibitors
Edrophonium
Neostigmine
Pyridostigmine Bromide
Vecuronium Bromide