Res Vestib Sci.  2019 Jun;18(2):54-58. 10.21790/rvs.2019.18.2.54.

Two Cases of Myasthenia Gravis Showing Fatigibility Presenting with Decreased Gain of Smooth Pursuit

Affiliations
  • 1Department of Neurology, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea. ohsun@jbnu.ac.kr
  • 2Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Korea.

Abstract

Myasthenia gravis (MG) is an autoimmune disease caused by autoantibodies to the acetylcholine receptors of the neuromuscular junction characterized by weakness and abnormal fatigability of the muscles. Therefore, the diagnosis of MG depends on the recognition of this distinctive pattern of fatigable weakness. Previous studies presented the diagnostic efficacy of saccadic eye movements in patients with ocular MG. We here in report 2 patients of ocular MG showing the fatigue effects during repetitive sustained smooth pursuit, and the effects of the administration of edrophonium on myasthenic smooth pursuit. Changes in smooth pursuits reflecting peripheral and secondary central mechanisms were demonstrated.

Keyword

Myasthenia gravis; Video-oculography; Smooth pursuit; Fatigibility

MeSH Terms

Autoantibodies
Autoimmune Diseases
Diagnosis
Edrophonium
Fatigue
Humans
Muscles
Myasthenia Gravis*
Neuromuscular Junction
Pursuit, Smooth*
Receptors, Cholinergic
Saccades
Autoantibodies
Edrophonium
Receptors, Cholinergic
Full Text Links
  • RVS
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
    DB Error: unknown error