- Effect of antianxiety drug augmentation in the neuroleptics treated schizophrenia patients
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Lim WJ, Woo HW
- KMID: 1692542
- J Korean Neuropsychiatr Assoc.
- 1993 Nov;32(6):971-982.
No abstract available. -
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- Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.
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Shah BH, Rasheed H, Rahman IH, Shariff AH, Khan FL, Rahman HB, Hanif S, Saeed SA
- KMID: 1457534
- Exp Mol Med.
- 2001 Dec;33(4):226-233.
Our recent studies have shown that co-activation of Gq and Gi proteins by 5-hydroxytryptamine (5-HT) and adrenaline show synergism in human platelet aggregation. This study was conducted to examine the... -
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- In vitro Synergism between Chloroquine and Antibiotics against Orientia tsutsugamushi
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Son D, Chung MH
- KMID: 2284975
- Infect Chemother.
- 2014 Sep;46(3):182-188.
- doi: 10.3947/ic.2014.46.3.182
BACKGROUND: To investigate whether chloroquine enhances the effect of antibiotics against Orientia tsutsugamushi, the causative organism of scrub typhus, we compared the effect of antibiotics in combination with chloroquine with... -
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- Drug Augmentation strategies in the Treatment of Mood Disdorder
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- KMID: 2334563
- J Korean Soc Biol Psychiatry.
- 1998 Nov;5(2):155-161.
Mood disorder is a medical illness resulting from the disorder of CNS neurotransmission and its principal therapeutic tool is pharmacotherapy. Psychotherapeutic drugs for mood disorder have some clinical limitations which... -
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- Synergistic anti-allodynic effect between intraperitoneal thalidomide and morphine on rat spinal nerve ligation-induced neuropathic pain
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Lee HG, Kim WM, Yoon MH, Park AR, Choi JI
- KMID: 2164870
- Korean J Anesthesiol.
- 2013 Oct;65(4):331-336.
- doi: 10.4097/kjae.2013.65.4.331
BACKGROUND: Thalidomide has been recognized as having an anti-allodynic effect against neuropathic pain induced by spinal nerve ligation. Its clinical beneficial effects are mainly derived from its immune-modulating property, which... -
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- A Novel, Potent, Small Molecule AKT Inhibitor Exhibits Efficacy against Lung Cancer Cells In Vitro
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Dinavahi S, Prasanna R, Dharmarajan S, Perumal Y, Viswanadha S
- KMID: 2403412
- Cancer Res Treat.
- 2015 Oct;47(4):913-920.
- doi: 10.4143/crt.2014.057
PURPOSE: Anomalies of Akt regulation, including overexpression in lung cancer, impart resistance to conventional chemotherapy and radiation, thereby implicating this kinase as a therapeutic intervention point. A novel scaffold of... -
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- In-Vitro Efficacy of Synergistic Antibiotic Combinations in Multidrug Resistant Pseudomonas Aeruginosa Strains
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Dundar D, Otkun M
- KMID: 1779615
- Yonsei Med J.
- 2010 Jan;51(1):111-116.
- doi: 10.3349/ymj.2010.51.1.111
PURPOSE: Combination antibiotic treatment is preferred in nosocomial infections caused by Pseudomonas aeruginosa (P. aeruginosa). In vitro synergism tests were used to choose the combinations which might be used in... -
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- Synergistic effect of peroxiredoxin II antisense on cisplatin-induced cell death
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Yoo YD, Chung YM, Park JK, Ahn CM, Kim SK, Kim HJ
- KMID: 931877
- Exp Mol Med.
- 2002 Sep;34(4):273-277.
Peroxiredoxin II (Prx II) is known not only to protect cells from oxidative damage caused by hydrogen peroxide (H2O2), but also to endow cancer cells with resistance to both... -
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- Efficacy of in vitro treatment of chronic myelogenous leukemia cell line, K562 cells, using 4-hydroperoxycyclophosphamide, alpha-interferon and gamma-interferon
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Lee JT, Park S, Lee JH, Kim BK, Kim NK
- KMID: 932127
- J Korean Med Sci.
- 1996 Feb;11(1):26-32.
- doi: 10.3346/jkms.1996.11.1.26
Alpha-interferon (alpha-IFN) and gamma-interferon (gamma-IFN) are highly effective biologic agents in the treatment of chronic myelogenous leukemia (CML). 4-hydroperoxycyclophosphamide (4-HC) is the most commonly used chemotherapeutic drug when purging bone... -
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- Hemodynamic Effects of Co-administration of Midazolam during Anesthesia Induction with Propofol and Remifentanil in Hypertensive Patients
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Kim JD, Kim JW, Kung HC, Kang JH, Shin HY, Kim DS, Ryu SJ, Kim KH
- KMID: 2384832
- Kosin Med J.
- 2017 Jun;32(1):36-46.
- doi: 10.7180/kmj.2017.32.1.36
OBJECTIVES: Propofol, midazolam and remifentanil are commonly used for clinical anesthesia. We compared the effects of midazolam-propofol-remifentanil and propofol-remifentanil on hemodynamic responses during anesthesia induction in hypertensive patients. METHODS: Seventy-six hypertensive... -
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- In Vitro Interactions of Antibiotic Combinations of Colistin, Tigecycline, and Doripenem Against Extensively Drug-Resistant and Multidrug-Resistant Acinetobacter baumannii
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Park GC, Choi JA, Jang SJ, Jeong SH, Kim CM, Choi IS, Kang SH, Park G, Moon DS
- KMID: 2373511
- Ann Lab Med.
- 2016 Mar;36(2):124-130.
- doi: 10.3343/alm.2016.36.2.124
BACKGROUND: Acinetobacter baumannii infections are difficult to treat owing to the emergence of various antibiotic resistant isolates. Because treatment options are limited for multidrug-resistant (MDR) A. baumannii infection, the discovery... -
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- The cardiovascular effects of midazolam co-induction to propofol for induction in aged patients
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Lim YS, Kang DH, Kim SH, Jang TH, Kim KH, Ryu SJ, Yu SB, Kim DS
- KMID: 1828028
- Korean J Anesthesiol.
- 2012 Jun;62(6):536-542.
- doi: 10.4097/kjae.2012.62.6.536
BACKGROUND: The aim of this study was to investigate whether a small dose of midazolam and lessening the propofol dosage could prevent cardiovascular change at tracheal intubation for induction in... -
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- The Interaction of Gabapentin and N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA) on Mechanical Allodynia in Rats with a Spinal Nerve Ligation
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Park JY, Jun IG
- KMID: 1785829
- J Korean Med Sci.
- 2008 Aug;23(4):678-684.
- doi: 10.3346/jkms.2008.23.4.678
We examined the antiallodynic interaction between gabapentin and adenosine A1 receptor agonist, N(6)-(2-phenylisopropyl)-adenosine R-(-)isomer (R-PIA), in a rat model of nerve ligation injury. Rats were prepared with ligation of left... -
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- Combination & Augmentation Strategies in the Treatment of Depressive Disorder
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Kim HS
- KMID: 1899246
- J Korean Soc Biol Psychiatry.
- 2000 Nov;7(2):131-139.
Even the pharmacotherapy is more effective than placebo for the treatment of depression, the outcome of pharmacoltherapy remains unsatisfactory for many patients. Apart from side effects, there are two major... -
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- Synergistic Effects Between Intrathecal Clonidine and Neostigmine in the Formalin Test
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Yoon MH, Yoo KY, Jeong CY
- KMID: 648310
- J Korean Med Sci.
- 2001 Aug;16(4):498-504.
- doi: 10.3346/jkms.2001.16.4.498
Spinal alpha-2 adrenoceptors and cholinergic receptors are involved in the regulation of acute nociception and the facilitated processing. The aim of this study was to examine the pharmacological effect of... -
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- alpha-Tocopheryl succinate potentiates the paclitaxel-induced apoptosis through enforced caspase 8 activation in human H460 lung cancer cells
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Lim SJ, Choi MK, Kim MJ, Kim JK
- KMID: 1009395
- Exp Mol Med.
- 2009 Oct;41(10):737-745.
- doi: 10.3858/emm.2009.41.10.080
Paclitaxel is one of the chemotheraputic drugs widely used for the treatment of nonsmall cell lung cancer (NSCLC) patients. Here, we tested the ability of alpha-tocopheryl succinate (TOS), another promising... -
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- Synergy of Arbekacin-based Combinations Against Vancomycin Hetero-intermediate Staphylococcus aureus
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Lee JY, Oh WS, Ko KS, Heo ST, Moon CS, Ki HK, Kiem S, Peck KR, Song JH
- KMID: 1781820
- J Korean Med Sci.
- 2006 Apr;21(2):188-192.
- doi: 10.3346/jkms.2006.21.2.188
This study was undertaken to evaluate the in vitro activities of arbekacin-based combination regimens against vancomycin hetero-intermediate Staphylococcus aureus (hetero-VISA). Combinations of arbekacin with vancomycin, rifampin, ampicillin-sulbactam, teicoplanin, or quinipristin-dalfopristin... -
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- Novel EGFR-TK Inhibitor EKB-569 Inhibits Hepatocellular Carcinoma Cell Proliferation by AKT and MAPK Pathways
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Kim H, Lim HY
- KMID: 1786011
- J Korean Med Sci.
- 2011 Dec;26(12):1563-1568.
- doi: 10.3346/jkms.2011.26.12.1563
Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular carcinoma (HCC). The aim of this study was to investigate the drug potential to... -
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- Evidence that Amphotericin B Mediates Reactivation of Latent Epstein-Barr Virus in Hodgkin's Lymphoma Allowing Cytotoxicity by Acyclovir
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Kast RE
- KMID: 1110758
- Yonsei Med J.
- 2006 Apr;47(2):287-290.
- doi: 10.3349/ymj.2006.47.2.287
This brief communication focuses on aspects of a recent case report (Yonsei Med J 2005;46:425-30) on a full and sustained remission of Hodgkin's lymphoma (HL) after a single day of... -
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- Additive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test
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Yoon MH, Park KD, Lee HG, Kim WM, An TH, Kim YO, Huang LJ, Hua CJ
- KMID: 1107530
- J Korean Med Sci.
- 2008 Dec;23(6):1033-1038.
- doi: 10.3346/jkms.2008.23.6.1033
The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect... -
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