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Associations of Genetic Variations in Mismatch Repair Genes MSH3 and PMS1 with Acute Adverse Events and Survival in Patients with Rectal Cancer Receiving Postoperative Chemoradiotherapy

Yang J, Huang Y, Feng Y, Li H, Feng T, Chen J, Yin L, Wang W, Wang S, Liu Y, Song Y, Li Y, Jin J, Tan W, Lin D

PURPOSE: Mismatch repair (MMR) deficiency plays a critical role in rectal cancer. This study aimed to explore the associations between genetic variations in seven MMR genes and adverse events (AEs)...
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Validation of Prediction Models for Mismatch Repair Gene Mutations in Koreans

Lee SY, Kim DW, Shin YK, Ihn MH, Lee SM, Oh HK, Ku JL, Jeong SY, Lee JB, Ahn S, Won S, Kang SB

PURPOSE: Lynch syndrome, the commonest hereditary colorectal cancer syndrome, is caused by germline mutations in mismatch repair (MMR) genes. Three recently developed prediction models for MMR gene mutations based on...
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Loss of ARID1A Expression in Gastric Cancer: Correlation with Mismatch Repair Deficiency and Clinicopathologic Features

Kim KJ, Jung HY, Oh MH, Cho H, Lee JH, Lee HJ, Jang SH, Lee MS

PURPOSE: The AT-rich interactive domain 1A (ARID1A) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered a tumor suppressor in many tumors....
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Clinical significance of mismatch repair genes immunohistochemical expression of complex endometrial hyperplasia

Han SJ, Kim MK

OBJECTIVE: Women with Lynch syndrome have an increased risk of developing colorectal and gynecologic malignancies such as endometrial cancer. Complex hyperplasia has about a 30% risk of developing into endometrial...
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Microsatellite Instability and Mismatch Repair Protein (hMLH1, hMSH2) Expression in Intrahepatic Cholangiocarcinoma

Kang YK, Kim WH

  • KMID: 2275436
  • Korean J Pathol.
  • 2005 Feb;39(1):9-14.
BACKGROUND: To clarify the role of the mismatch repair (MMR) system in the carcinogenesis of intrahepatic cholangiocarcinoma (ICC), we investigated the microsatellite instability (MSI) status and MMR protein expression in...
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Genetic Instability and Mutations of Mismatch Repair (MMR) and p53 Gene in Colorectal Cancers with Multiple Polyps and Sporadic Colorectal Cancers

Chun SW, Chang SK

  • KMID: 2334284
  • J Korean Soc Coloproctol.
  • 2002 Dec;18(6):353-362.
PURPOSE: General conceptions of carcinogenic mechanisms by recent reports are ras-p53 gene pathway in sporadic colorectal cancers (SCC), MMR gene pathway in hereditary nonpolyposis colorectal cancer (HNPCC) and APC gene...
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Gastric Cancer and DNA Mismatch Repair

Kim JJ, Park DI

  • KMID: 1598593
  • Korean J Gastroenterol.
  • 2001 Apr;37(4):233-239.
Cancer developes when mutations accumulate in key growth-regulating genes. The two classes of genes implicated in this malignant transformation are designated oncogenes and tumor-suppressor genes. Recently, a new class of...
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Expression Pattern of DNA Mismatch Repair Genes in Tumors of Microsatellite Mutator Phenotype

Kim JJ, Baek MJ, Kim NG, Kim YH, Kim JE, Kim H, Park C

  • KMID: 1725720
  • Korean J Pathol.
  • 2000 Sep;34(9):609-614.
Microsatellite mutator phenotype (MMP) tumors were reported in a subset of gastrointestinal carcinomas. The molecular pathogenesis of MMP tumors shows defects in the DNA mismatch repair genes, and also many...
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Mutation of DNA Mismatch Repair Genes and its Relation to Taxol and Topotecan Chemosensitivity in the Clones from the Cisplatin-Resistant Ovarian Cancer Cell Lines

Kim HK, Son WS, Park TC, Kim TE, Koh YM, Song JM, Park KY, Kim JH, Ryu KS, Kim JW, NamKoong S, Kim SP

  • KMID: 2075936
  • Korean J Obstet Gynecol.
  • 1999 Nov;42(11):2465-2473.
OBJECTIVE: Ovarian cancer represents a relatively chemosensitive solid tumor, with responsiveness to a range of agents. Cisplatin is the mainstay of drug treatment and is one of the most active...
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