Korean J Obstet Gynecol.  2009 Nov;52(11):1164-1168.

One case of Lynch type II syndrome

Affiliations
  • 1Department of Obstetrics and Gynecology, Presbyterian Medical center, Jeon-ju, Korea. kyungjin_k@hotmail.com
  • 2Department of pathology, Presbyterian Medical center, Jeon-ju, Korea.

Abstract

Lynch syndrome is also called Hereditary nonpolyposis colorectal cancer (HNPCC). It is characterized by a risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine etc. The increased risk is due to inherited mutations that impaired DNA mismatch repair. Two to three percentage of colon cancer is caused by Lynch syndrome. A family history of colon cancer occurs at a young age. We experienced one case of Lynch syndrome who had had stomach cancer, endometrial cancer and colon cancer recently. Hence we report this case with a brief review of literature.

Keyword

Endometrial cancer; HNPCC; Colorectal cancer; MSI (microsatellite instability); MMR (mismatch repair)

MeSH Terms

Colonic Neoplasms
Colorectal Neoplasms
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Mismatch Repair
Endometrial Neoplasms
Endometrium
Female
Humans
Intestine, Small
Ovary
Stomach
Stomach Neoplasms
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