Korean J Urol Oncol.  2018 Aug;16(2):58-62. 10.22465/kjuo.2018.16.2.58.

Prognostic Significance of Immunohistochemical MSH2 Expression in Prostate Cancer

• Kim YB
• Lee DG
• Yoo KH
• Lee HL
• Choi SK

• KMID: 2438595
• DOI: http://doi.org/10.22465/kjuo.2018.16.2.58

Abstract

PURPOSE
There are numerous prostate cancer-related genes that involve in carcinogenesis and tumor progression. Among the genes, DNA mismatch repair genes recognize and repair misincorporated nucleotides during DNA replication. In this analysis, we evaluated the association of hMSH2 which is one of the mismatch repair genes, with risk of aggressive prostate cancer and prostate cancer recurrence.
MATERIALS AND METHODS
Immunohistochemistry was performed in 46 patients who diagnosed prostate cancer and underwent radical prostatectomy between January 2006 and December 2012 at Kyung Hee University Hospital at Gangdong. We evaluated an association between the degree of hMSH2 immunohistochemical staining and various clinical variables including prostate-specific antigen (PSA), Gleason score, pathological stage, and biochemical recurrence. The intensity of immunostaining for hMSH2 was divided into 2 groups: low expression group (immunostaining score < 2) and high expression group (immunostaining score ≥2).
RESULTS
Although seminal vesicle invasion was marginally associated with the degree of hMSH2 immunohistochemical staining, PSA, Gleason score, lymph node metastasis, presence of lymphatic, perineural, vascular invasion, and extracapsular extension were not associated with the degree of hMSH2 immunohistochemical staining. Furthermore, the association of biochemical recurrence free survival with hMSH2 expression was not statistically significant.
CONCLUSIONS
The hMSH2 expression was marginally associated with risk of aggressive prostate cancer such as seminal vesicle invasion. Further evaluation with a larger number of cases is needed to verify these results.

Keyword

Prostate; Gene expression; Prostatic neoplasms; DNA repair; Base pair mismatch

MeSH Terms

Base Pair Mismatch
Carcinogenesis
DNA Mismatch Repair
DNA Repair
DNA Replication
Gene Expression
Humans
Immunohistochemistry
Lymph Nodes
Neoplasm Grading
Neoplasm Metastasis
Nucleotides
Prostate*
Prostate-Specific Antigen
Prostatectomy
Prostatic Neoplasms*
Recurrence
Seminal Vesicles
Nucleotides
Prostate-Specific Antigen