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Chimeric Antigen Receptor T Cell Therapy: A Novel Modality for Immune Modulation

Yoon S, Eom GH

Cancer remains a leading cause of death, despite multimodal treatment approaches. Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. Cancer cells...
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Rapid Functional Enhancement of Ankylosing Spondylitis with Severe Hip Joint Arthritis and Muscle Strain

Hwang S, Im SH, Shin JC, Park J

Arthritis of hip joints deteriorates the quality of life in ankylosing spondylitis (AS) patients. Secondary to the articular inflammatory process, the shortened hip-girdle muscles contribute to the decreased joint mobility...
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The prognostic factors influencing overall survival in uterine cervical cancer with brain metastasis

Kim H, Lee KK, Heo MH, Kim JY

BACKGROUND/AIMS: The occurrence of brain metastasis (BM) has increased due to improved overall survival (OS) in uterine cervical cancer. However, research about prognostic factors and therapeutic guidelines for BM in...
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Chemoradiotherapy for Esophageal Cancer

Park MI

Esophageal cancer is a highly lethal malignancy. Squamous cell cancer (SCC) and adenocarcinoma are two major histologic types of esophageal cancer. The therapeutic approaches for both histologic types tend to...
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Preliminary results of entire pleural intensity-modulated radiotherapy in a neoadjuvant setting for resectable malignant mesothelioma

Hong JH, Lee HC, Choi KH, Moon SW, Kim KS, Hong SH, Hong JY, Kim YS, Multidisciplinary Team of Lung Cancer in Seoul St. Mary's Hospital

PURPOSE: The purpose of this study is to evaluate the safety and efficacy of the multimodality treatment with neoadjuvant intensity-modulated radiotherapy (IMRT) for resectable clinical T1-3N0-1M0 malignant pleural mesothelioma (MPM). MATERIALS...
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Multimodal Treatment Strategies in Esophagogastric Junction Cancer: a Western Perspective

Goetze TO, Al-Batran , Berlth F, Hoelscher

Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely...
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Neutrophil-to-lymphocyte ratio independently predicts advanced pathological staging and poorer survival outcomes in testicular cancer

Tan YG, Sia J, Huang HH, Lau WK

PURPOSE: An elevated neutrophil-to-lymphocyte ratio (NLR) has been associated with adverse outcomes in various malignancies. However, its role in prognosticating testicular cancer (TC) has not been validated. We aim to...
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Preoperative chemoradiation followed by hysterectomy for cervical cancer: patterns of care and survival in a large, hospital database

Albert A, Allbright , Lee A, Vijayakumar S

OBJECTIVE: Adjuvant hysterectomy following chemoradiation (CRT) is a treatment option used worldwide for early-stage cervical cancer but the benefit of hysterectomy in this setting is unclear. An analysis of the...
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The Prognostic Impact of the Number of Metastatic Lymph Nodes and a New Prognostic Scoring System for Recurrence in Early-Stage Cervical Cancer with High Risk Factors: A Multicenter Cohort Study (KROG 15-04)

Kwon J, Eom KY, Kim YS, Park W, Chun M, Lee J, Kim YB, Yoon WS, Kim JH, Choi JH, Chang SK, Jeong BK, Lee SH, Cha J

PURPOSE: We aimed to assess prognostic value of metastatic pelvic lymph node (mPLN) in early-stage cervical cancer treated with radical surgery followed by postoperative chemoradiotherapy. Also, we sought to define...
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Treatment of Oligometastatic Hormone-Sensitive Prostate Cancer: A Comprehensive Review

Koo KC, Dasgupta P

With advancements in diagnostic techniques, including molecular and clinical imaging, that directly target cancer cells, oligometastatic prostate cancer (PCa) is being diagnosed in patients who were, in the past, considered...
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Treatment outcomes of radiotherapy for anaplastic thyroid cancer

Park JW, Choi SH, Yoon HI, Lee J, Kim TH, Kim JW, Lee IJ

PURPOSE: Anaplastic thyroid cancer (ATC) is a rare tumor with a lethal clinical course despite aggressive multimodal therapy. Intensity-modulated radiotherapy (IMRT) may achieve a good therapeutic outcome in ATC patients,...
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Preoperative short course radiotherapy with concurrent and consolidation chemotherapies followed by delayed surgery in locally advanced rectal cancer: preliminary results

Aghili M, Sotoudeh S, Ghalehtaki R, Babaei M, Farazmand , Fazeli MS, Keshvari A, Haddad P, Farhan F

PURPOSE: This study aimed to assess complications and outcomes of a new approach, that is, combining short course radiotherapy (SRT), concurrent and consolidative chemotherapies, and delayed surgery. MATERIALS AND METHODS: In...
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Outcomes of the Multimodal Treatment of Malignant Pleural Mesiothelioma: The Role of Surgery

Na BS, Kim JS, Hyun K, Park IK, Kang CH, Kim YT

BACKGROUND: The treatment of malignant pleural mesothelioma (MPM) is challenging, and multimodal treatment including surgery is recommended; however, the role of surgery is debated. The treatment outcomes of MPM in...
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Two Cases of Nuclear Protein in Testis Midline Carcinomas of Sinonasal Tract

Lee M, Kang YS, Won TB, Kim HJ

Nuclear protein in testis (NUT) midline carcinoma (NMC) is a rare and aggressive tumor that is genetically characterized by chromosomal rearrangement of the NUT gene. NMC predominantly involves the midline...
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Surgical treatment of perianal fistula in Crohn's disease

Kim S

Perianal Crohn's disease is a major problem that impair quality of life. This article reviews the current surgical treatment of Crohn's perianal fistula. Fistulotomy and loose seton are commonly used...
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Programmed death-1 pathway blockade produces a synergistic antitumor effect: combined application in ovarian cancer

Zhu X, Lang J

Programmed death-1 (PD-1) and its ligand are part of the immune checkpoint pathway that down-regulates effector T cells in immune response, thereby causing immune suppression. The PD-1/programmed death-ligand 1 (PD-L1)...
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Is There Additive Therapeutic Effect When GCSF Combined with Adipose-Derived Stem Cell in a Rat Model of Acute Spinal Cord Injury?

Min J, Kim JH, Choi KH, Yoon HH, Jeon SR

OBJECTIVE: Functional and neural tissue recovery has been reported in many animal studies conducted with stem cells. However, the combined effect of cytokines and stem cells has not yet been...
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Effects of neural stem cells and 5-fluorocytosine in canine metastatic lung tumor

Hwang Y, Kim D, Chang D, Ahn B, Kim YB, Kim G

This is the first case report to describe the tumor regressive effect of systemic human neural stem cell (NSC)/5-fluorocytosine (5-FC) therapy on canine metastatic lung tumor. The therapeutic effects appeared...
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Endoscopic Treatment of an Adult with Tegmental Astrocytoma Accompanied by Cerebrospinal Fluid Dissemination

Lu R, Li C, Wang X, Zhang Y

Midbrain gliomas are relatively rare neoplasms with a generally benign prognosis, with dissemination or metastasis not previously reported. We describe here a woman, in whom magnetic resonance imaging scans showed...
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Multidisciplinary team approach for the management of patients with locally advanced non-small cell lung cancer: searching the evidence to guide the decision

Oh IJ, Ahn SJ

Locally advanced non-small cell lung cancer (LA-NSCLC) is composed of heterogeneous subgroups that require a multidisciplinary team approach in order to ensure optimal therapy for each patient. Since 2010, the...
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