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Mucoepidermoid Carcinoma on Submandibular Salivary Gland as a Second Malignant Neoplasm after Treatment of Yolk Sac Tumor

Keum HS, Kang JI, Yoo ES, Park HJ, Lee SW, Ryu KH

Malignant salivary gland tumors only represent 0.08% of all childhood tumors and mucoepidermoid carcinoma (MEC) is the most common histologic type. Although there are many reports describing second malignant neoplasm...
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A Case of Appendicitis with Liver Abscesses Developed during Allogeneic Hematopoietic Stem Cell Transplantation

Lee SB, Lee JM, Lee SW, Yoo ES, Ryu KH

A 10-year-old boy with severe aplastic anemia was admitted for allogeneic hematopoietic stem cell transplantation. After conditioning chemotherapy using cyclophosphamide, fludarabine, and antithymocyte immunoglobulin, he presented with fever and abdominal...
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Low Dose Methotrexate induced Bullous Acral Erythema in a Child with Acute Lymphoblastic Leukemia

Cho SY, Lee JH

Chemotherapy-induced acral erythema (CIAE) is an uncommon, self-limited local skin reaction that usually occurs after high-dose chemotherapy. There is no specific treatment for this disease and it disappears within three...
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Two Cases of Multiple Endocrine Neoplasia Type II with RET Mutaion

Yoo SY, Choi YH, Lee MK, Kim MS, Hwang PH

Multiple endocrine neoplasia type 2(MEN2) is a rare autosomal dominant inherited disorder characterized by the presence of medullary thyroid carcinoma, pheochromocytoma and other hyperplasia and/or neoplasia of different endocrine tissues...
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An Adolescent Case of Castleman Disease of the Plasma Cell Type Treated with Radiotherapy

Heo TH, Lim HW, Sim JH, Lee JH, Lee EH, Lee KC

Castleman disease (CD) is a disorder with distinct lymphoid hyperplasia of unknown origin, and it is rare in children. There are two major forms of CD: unicentric (localized) and multicentric....
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A Case of Reticulohistiocytoma Mimicking Primary Cutaneous CD 4 Positive Small/medium T-cell Lymphoma

Yoon L, Jun SE, Seo JH, Lim YT

Reticulohistiocytoma is a rare, benign histiocytic proliferation of the skin or soft tissue. A 5-month-old healthy girl visited our clinic for an enlarging nodule on the center of her right...
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A Pediatric Case of Acute Myeloid Leukemia with t(3;5)(q25;q34)

Kim BY, Jeon IS

Acute myeloid leukemia (AML) with t(3;5)(q25;q34), belonging to AML with myelodysplasia related changes according to WHO classification in 2008, is a subtype of AML that is particularly rare in children....
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Lupus Anticoagulant-hypoprothrombinemia Syndrome as an Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

Sul Y, Lee JH, Park YS, Koh KN, Im HJ, Seo JJ

The lupus anticoagulant-hypoprothrombinemia syndrome, characterized by presence of lupus anticoagulant with acquired factor II deficiency, is a rare disease entity often presented with acute bleeding episodes. A 15-year-old girl was...
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A Case of Thrombotic Microangiopathy Following Autologous Stem Cell Transplantation

Choi JY, Lee JW, Ju HY, Hong CR, Kim H, Lee DS, Kim NH, Kang HJ, Park KD, Shin HY

Transplantation-associated thrombotic microangiopathy (TA-TMA) is an uncommon but devastating complication in patients who undergo hematopoietic stem cell transplantation (SCT). However, the optimal treatment strategy for TA-TMA is unclear. We report...
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A Case of Childhood Paroxysmal Cold Hemoglobinuria Related with Suspicious Chlamydia Infection

Yoon JH, Cho JS, Park HJ, Shim H, Kong SY, Yoon JY, Park BK

Paroxysmal cold hemoglobinuria (PCH) is a rare diagnosis of acquired hemolytic anemia in children, which is caused by a specific cold antibody named Donath-Landsteiner hemolysin. Although various bacteria or viruses...
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Lower Diagnostic Value of Bone Marrow Biopsy in Children with Fever of an Unknown Origin

Yang SM, Jin SL, Kim HS, Hahn SM, Lyu CJ, Han JW

BACKGROUND: Diagnostic value of Bone marrow (BM) biopsies for fever of unknown origin (FUO) remain controversial and BM biopsies are difficult to perform in young patients. Our study aimed to...
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Evaluation of Cardiac Function in Children with Solid Tumors, who Underwent Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation

Kim YS, Song J, Sung KW, Lee SH, Yoo KH, Huh J, Kang IS, Koo HH

BACKGROUND: Even though the five year survival rate and prognosis of childhood solid tumors have been improved through the introduction of dose-escalation using tandem high-dose chemotherapy and autologous stem cell...
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Nasopharyngeal Carcinoma in Children and Adolescents: Single Institution Study

Choi JY, Kang HJ, Ju HY, Hong CR, Kim IH, Park SH, Kim IO, Park KD, Shin HY

BACKGROUND: Nasopharyngeal carcinoma (NPC) is very rare in children and adolescents. The aim of this study was to evaluate clinical characteristics and treatment outcomes of pediatric NPC. METHODS: Medical records of...
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Prognostic Factors and Outcome in Childhood and Adolescent Osteosarcoma: Single Institution Experience

Lee MJ, Choe HY, Jang HI, Jung ST, Choi YD, Heo SH, Baek HJ, Kook H

BACKGROUND: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. The aim of this study was to evaluate survival and the prognostic factors in children and...
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Radiation or Chemotherapy rather than Observation may be a Better Modality after Subtotal Resection for Pilocytic Astrocytoma in Children

Jung SY, Jin SL, Hahn SM, Kim HS, Kim DS, Seo CO, Lyu CJ, Han JW

BACKGROUND: Pilocytic astrocytoma (PA) is a low-grade glioma that occurs primarily in children and young adults. The optimal postoperative treatment modality after subtotal resection (STR) of PAs remains to be...
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Treatment Outcomes and Prognostic Factors in Children with Non-Hodgkin Lymphoma at a Single Institution

Kim JS, Kong SG, Oh CE, Yoo HY, Park JS

BACKGROUND: Treatment outcomes of children with non-Hodgkin lymphoma (NHL) have dramatically improved in recent years. However, there are few studies on the outcomes of pediatric NHL in Korea. METHODS: We retrospectively...
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Standard Induction Followed by Low Dose Cytarabine for the Treatment of Acute Myeloid Leukemia of Down Syndrome

Kyung YC, Choi YB, Lee NH, Lee SH, Sung KW, Koo HH, Yoo KH

BACKGROUND: Although acute myeloid leukemia occurring in patients with Down syndrome (AML-DS) is generally chemosensitive, these patients are more susceptible to regimen-related toxicities, and the optimal post-remission therapy for AML-DS...
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Prevalence and Clinical Implication of Partial Tandem Duplication of the Mixed Lineage Leukemia Gene in Pediatric Acute Leukemia

Jin SL, Hahn SM, Kim HS, Lyu CJ, Han JW

BACKGROUND: The mixed lineage leukemia (MLL) gene may induce hematopoiesis and leukemia. Partial tandem duplication of MLL (MLL-PTD) is associated with poor prognosis in acute myeloid leukemia (AML); however, the...
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The Effect of Lupus Anticoagulant Detected in Children with Respiratory Tract Infection on in vitro Coagulation Time

Kim YH, Jeon IS

BACKGROUND: This study was conducted in order to investigate the prevalence of lupus anticoagulant (LA) in children with respiratory tract infection and to evaluate the effect of LA on in...
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Clinical and Laboratory Features of Severe Neutropenia Developed in Childhood

Lee JH, Kim SH, Kim SK, Lee JW, Jang PS, Kim M, Chung NG, Cho B, Kim HK

BACKGROUND: Neutropenia is not uncommon in children. We performed this study to investigate the etiology, clinical course and laboratory characteristics for prediction of recovery in children with severe neutropenia. METHODS: In...
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