Clin Pediatr Hematol Oncol.  2014 Oct;21(2):86-94. 10.15264/cpho.2014.21.2.86.

Treatment Outcomes and Prognostic Factors in Children with Non-Hodgkin Lymphoma at a Single Institution

Affiliations
  • 1Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.
  • 2Seoul Children's Hospital, Jinhae, Korea.
  • 3Department of Pediatrics, Dong-nam Institute of Radiological & Medical Sciences, Busan, Korea. pjshuman4803@hanmail.net

Abstract

BACKGROUND
Treatment outcomes of children with non-Hodgkin lymphoma (NHL) have dramatically improved in recent years. However, there are few studies on the outcomes of pediatric NHL in Korea.
METHODS
We retrospectively analyzed the outcomes of 34 children diagnosed with NHL and treated at Kosin University Gospel Hospital from Jan. 1987 to Dec. 2009, according to age, lactate dehydrogenase (LDH) level, histology, stage and involved site.
RESULTS
The mean age of the subjects was 9.0 years. The abdomen and head/neck regions were the most common primary sites. On histologic classification, Burkitt lymphoma was the most common, followed by lymphoblastic lymphoma, diffuse large B-cell lymphoma, anaplastic large cell lymphoma, and unclassifiable, with respective incidences of 35.3%, 23.5%, 17.6%, 17.6%, and 5.9%. Various combination chemotherapies according to the diagnosis with mean treatment duration of 14.9 months showed 5 year event free survival (EFS) and 5 year overall survival (OS) rate of 67.7+/-8.0% and 79.3+/-7.0%, respectively. Nine out of the 34 patients relapsed, and the 5 year OS rates for those who relapsed vs. 25 patients without relapse were 44.4+/-16.6%, vs. 92.0+/-5.4%, respectively (P<0.01). Although 5 year EFS rate varied according to stage, 5 year OS rate were not different according to age, sex, LDH, stage, histology, or treatment period.
CONCLUSION
The outcome of children with NHL treated in our setting was comparable to those of other large centers in Korea. No factor other than stage, including LDH, histologic subtype showed significant prognostic value.

Keyword

Non-Hodgkin lymphoma; Survival; Prognostic factors; Children

MeSH Terms

Abdomen
Burkitt Lymphoma
Child*
Classification
Diagnosis
Disease-Free Survival
Drug Therapy, Combination
Humans
Incidence
Korea
L-Lactate Dehydrogenase
Lymphoma, B-Cell
Lymphoma, Large-Cell, Anaplastic
Lymphoma, Non-Hodgkin*
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence
Retrospective Studies
L-Lactate Dehydrogenase
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