Clin Pediatr Hematol Oncol.  2014 Oct;21(2):153-156. 10.0000/cpho.2014.21.2.153.

A Case of Reticulohistiocytoma Mimicking Primary Cutaneous CD 4 Positive Small/medium T-cell Lymphoma

• Yoon L
• Jun SE
• Seo JH
• Lim YT

• KMID: 2279827
• DOI: http://doi.org/10.0000/cpho.2014.21.2.153

Abstract

Reticulohistiocytoma is a rare, benign histiocytic proliferation of the skin or soft tissue. A 5-month-old healthy girl visited our clinic for an enlarging nodule on the center of her right palm. The clinical differential diagnosis included xanthogranuloma and primary cutaneous CD4 positive small/medium T-cell lymphoma. Histopathology of the nodule showed abundant eosinophilic and glassy cytoplasm. The nuclei were round to oval shaped, with focal irregular nuclear membrane, and mitotic figures were absent. Immunohistochemical study determined that the cells were positive for CD68 but negative for CD1a. She was finally diagnosed with reticulohistiocytoma (solitary epithelioid histiocytoma).

Keyword

Reticulohistiocytoma; Solitary epithelioid histiocytoma; Skin; Palm

MeSH Terms

Cytoplasm
Diagnosis, Differential
Eosinophils
Female
Histiocytosis, Non-Langerhans-Cell*
Humans
Infant
Lymphoma, T-Cell*
Nuclear Envelope
Skin