Clin Pediatr Hematol Oncol.  2014 Oct;21(2):157-162. 10.0000/cpho.2014.21.2.157.

An Adolescent Case of Castleman Disease of the Plasma Cell Type Treated with Radiotherapy

• Heo TH
• Lim HW
• Sim JH
• Lee JH
• Lee EH
• Lee KC

• KMID: 2279828
• DOI: http://doi.org/10.0000/cpho.2014.21.2.157

Abstract

Castleman disease (CD) is a disorder with distinct lymphoid hyperplasia of unknown origin, and it is rare in children. There are two major forms of CD: unicentric (localized) and multicentric. Pathologically, it can be categorized into three subtypes: hyaline- vascular, plasma cell, and mixed types. We experienced a 15-year-old boy with histopathologically proven mediastinal CD of the plasma cell type. He was referred to our hospital because of mediastinal widening in a chest x-ray found by chance. Surgery was performed to resect two right paratracheal masses and subtotal excision was done. As complete surgical resection was not possible, the patient subsequently received three-dimensional conformal radiation therapy (total 5,400 cGy in 27 fractions). The size of the mass decreased, and his clinical symptoms regressed without any side effects from radiotherapy. Here we report a case of unicentric plasma cell type CD, treated with radiotherapy due to incomplete surgical resection.

Keyword

Castleman disease; Child; Lymphoproliferative disorders; Radiotherapy; Case reports

MeSH Terms

Adolescent*
Child
Giant Lymph Node Hyperplasia*
Humans
Hyperplasia
Lymphoproliferative Disorders
Male
Plasma Cells*
Radiotherapy*
Thorax