Korean J Pediatr Hematol Oncol.  1998 Oct;5(2):333-339.

A Case of Plasma Cell Type Giant Lymph Node Hyperplasia (Castleman's Disease)

Affiliations
  • 1Department of Pediatrics, Ajou University College of Medicine, Suwon, Korea.
  • 2Department of Pathology, Ajou University College of Medicine, Suwon, Korea.
  • 3Department of Thoracic surgery, Ajou University College of Medicine, Suwon, Korea.

Abstract

Castleman's disease was first described in 1956 in a group of patients with localized mediastinal lymph node enlargement characterized by hyperplasia of lymphoid follicles and marked capillary proliferation with endothelial hyperplasia. They have been divided into 2 histologic types: the hyaline-vascular type, which was more common and usually asymptomatic, was characterized by small hyaline-vascular follicles and interfollicular capillary proliferation; the plasma-cell type was characterized by large follicles with intervening sheets of plasma cells. Systemic manifestations, such as fever, anemia and hyperglobulinemia, were frequently associated with the plasma cell type. Localized lesions have behaved in a benign fashion, and complete surgical excision has been curative. But recent years, reports have described a multicentric variety with severe systemic manifestations, exorable clinical course and poor outcome. Although Castleman's disease has been described at all ages, the disease is rare in childhood. This paper describes a case of plasma cell type Castleman's disease in a 12-year-old boy and review of the literature. We conclude that the Castleman's disease must be considered in childhood lymphadenopathy and the clinicians should be mindful of the malignant potential of the disease and their possible multicentricity. Appropriate treatment plan, close follow-up and periodic surveillance are necessary.

Keyword

Castleman's disease; Plasma cell type; Childhood

MeSH Terms

Anemia
Capillaries
Child
Fever
Follow-Up Studies
Giant Lymph Node Hyperplasia*
Humans
Hyperplasia
Lymph Nodes
Lymphatic Diseases
Male
Plasma Cells*
Plasma*
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