Clin Pediatr Hematol Oncol.  2014 Oct;21(2):168-171. 10.0000/cpho.2014.21.2.168.

Low Dose Methotrexate induced Bullous Acral Erythema in a Child with Acute Lymphoblastic Leukemia

• Cho SY
• Lee JH

• KMID: 2279830
• DOI: http://doi.org/10.0000/cpho.2014.21.2.168

Abstract

Chemotherapy-induced acral erythema (CIAE) is an uncommon, self-limited local skin reaction that usually occurs after high-dose chemotherapy. There is no specific treatment for this disease and it disappears within three to five weeks. In this case report, we present a 16-year-old female with acute lymphoblastic leukemia who developed severe CIAE. The lesions appeared as a well-defined erythema of the hands, feet, and back with symmetrically well-defined borders 5 days after low-dose MTX treatment. The erythema progressed to bullae formation and desquamation. It resolved spontaneously within 2 weeks. CIAE is very uncommon in children; however we should consider acral erythema as a differential diagnosis when bullous skin reaction occurs in a patient who receives chemotherapy.

Keyword

Acral erythema; Chemotherapy side effect; Methotrexate

MeSH Terms

Adolescent
Child*
Diagnosis, Differential
Drug Therapy
Erythema*
Female
Foot
Hand
Hand-Foot Syndrome
Humans
Methotrexate*
Precursor Cell Lymphoblastic Leukemia-Lymphoma*
Skin
Methotrexate