Ann Dermatol.  2007 Dec;19(4):160-162. 10.5021/ad.2007.19.4.160.

A Case of Methotrexate-induced Bullous Acral Erythema

• Han YW
• Lee KH
• Park CJ

• KMID: 2156341
• DOI: http://doi.org/10.5021/ad.2007.19.4.160

Abstract

Chemotherapy-induced acral erythema (CIAE) is a toxic reaction to a number of different chemotherapeutic agents, and causes symmetrical, well-demarcated, painful erythema on the palms and soles which is self-limiting. CIAE with bullous reaction in relation to methotrexate has been reported, but it is more commonly associated with cytosine arabinoside. The differential diagnosis of this condition from more serious conditions such as graft-vs-host disease or toxic epidermal necrolysis is essential. In this paper, we report the case of a 65-year-old man who developed bullous acral erythema after the administration of high-dose methotrexate for the treatment of Non-Hodgkin's lymphoma.

Keyword

Methotrexate; Bullous acral erythema

MeSH Terms

Aged
Cytarabine
Diagnosis, Differential
Erythema*
Graft vs Host Disease
Hand-Foot Syndrome
Humans
Lymphoma, Non-Hodgkin
Methotrexate
Stevens-Johnson Syndrome
Cytarabine
Methotrexate