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Use of Disease-modifying Antirheumatic Drugs After Cancer Diagnosis in Rheumatoid Arthritis Patients

Joo YB, Jeong SM, Park YJ, Kim KJ, Park KS

Objective: There is no recommendation for the use of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA) who developed cancer. We examined changes in the DMARDs prescription patterns...
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Fatal multiorgan dysfunction following repeated iodinated radiocontrast injection in a patient receiving low-dose oral methotrexate -a case report-

Vaithialingam B, Muthuchellappan R, Sundaram M

Background: Methotrexate is an antimetabolite drug that blocks dihydrofolate reductase and impairs cellular DNA synthesis. Administration of intravenous iodinated radiocontrast agents can cause life-threatening toxicity in patients receiving methotrexate. Case:...
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Evaluation of Serum Matrix Metalloproteinase-3 as an Objective Indicator for the Disease Activity in Rheumatoid Arthritis Patients Treated With Methotrexate Versus Tocilizumab: 24-week Results From a Prospective Randomized Controlled Study

Yeo J, Baek HJ, Song YW, Lee EY

Objective: This study aims to evaluate the change in serum metalloproteinase-3 (MMP-3) following the management of active rheumatoid arthritis (RA) and define the relationships between MMP-3 and disease activity indices. Methods:...
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Assessment on Treatments With Conventional Synthetic Disease-modifying Drugs Before Initiating Biologics in Patients With Rheumatoid Arthritis in Korea: A Populationbased Study

Kim MJ, Park EH, Shin A, Ha YJ, Lee YJ, Lee EB, Baek HJ, Kang EH

Objective: To assess pre-biologic treatments with conventional synthetic disease-modifying drugs (csDMARDs) prior to biologics initiation among patients with rheumatoid arthritis (RA). Methods: Using Korea National Health Insurance database, we examined pre-biologic...
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Two Cases of Lymphomatoid Papulosis Mimicking Pseudolymphoma Successfully Treated with Low-Dose Methotrexate and 308-nm Ultraviolet Laser Therapy

Kang H, Lee SH, Choi EH

  • KMID: 2526780
  • Korean J Dermatol.
  • 2022 Feb;60(2):130-134.
Lymphomatoid papulosis (LyP) is a CD30+ lymphoproliferative disorder characterized by chronic papulonodular eruptions. Highly potent topical steroids and phototherapy are the first-line modalities, and low-dose methotrexate (MTX) combined with folic...
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Protective effects of curcumin against methotrexate-induced testicular damage in rats by suppression of the p38-MAPK and nuclear factor-kappa B pathways

Kilinc L, Uz YH

Objective: Methotrexate (MTX), is a commonly used chemotherapeutic agent. This study aimed to investigate the possibility that curcumin (CMN) protects against MTX-induced testicular damage by affecting the phospho (p)-p38 mitogen-activated...
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Therapeutic Efficacy and Safety of Methotrexate in Moderate-to-Severe Atopic Dermatitis: A Retrospective Study of Korean Patients at Tertiary Referral Hospital

Lee JH, Yun SJ, Lee JB, Lee SC

Background: Methotrexate (MTX) has been prescribed to suppress atopic dermatitis (AD) symptoms and flares in moderate-to-severe cases. Objective: The purpose of this study was to evaluate the therapeutic efficacy and...
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Refractoty Hailey-Hailey Disease Treated with Methotrexate

Her Y

  • KMID: 2504354
  • Korean J Dermatol.
  • 2020 Jul;58(6):432-433.
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The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy

Wu X, Qin J, Shen T, Fei W, Chen L, Xie X, Lu W

Objective: To assess the outcomes and toxic effects of 5-day actinomycin D (Act-D) salvage therapy and to explore the predictors of Act-D resistance in patients with low-risk gestational trophoblastic neoplasia...
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Steroid-resistant sarcoid myositis thatwas successfully treated with oralmethotrexate

Noh KH, Huh SY, Park YE, Shin JH, Kim DS

Acute sarcoid myositis is rarely complicated by sarcoidosis, and steroid therapy is considered the standard treatment. We experienced a patient with acute sarcoid myositis who did not respond to aggressive high-dose corticosteroid...
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Combination of Methotrexate and Leflunomide for Adult-onset Still's Disease: A Case Report and Literature Review

Lee EE, Kim MJ, Song YW, Park JK

The treatment of adult-onset Still's disease (AOSD) aims to control systemic inflammation and prevent organ damage. Systemic inflammation can be controlled with corticosteroid (CS) monotherapy in most cases. However, symptoms...
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Methotrexate-Induced Leukoencephalopathy Presenting Like Acute Stroke

Ha WS, Choi BK, Koo Y, Nam HS

No abstract available.
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Effect of lutein on methotrexate-induced oxidative lung damage in rats: a biochemical and histopathological assessment

Mammadov R, Suleyman B, Akturan S, Cimen FK, Kurt N, Suleyman Z, Malkoc I

BACKGROUND/AIMS: This study aimed to investigate the effect of lutein on methotrexate (MTX)-induced pulmonary toxicity in rats biochemically and histopathologically. METHODS: The rats in the MTX + lutein (MTXL, n =...
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Efficacy of Slow Rate Ventriculolumbar Perfusion Chemotherapy for Leptomeningeal Carcinomatosis: Interim Result of a Phase II Study

Choi YH, Gwak HS, Joo J, Kwon JW, Shin SH, Yoo H, Lee JH, Youn JH

BACKGROUND: To evaluate the efficacy of modified ventriculolumbar perfusion (VLP) chemotherapy with methotrexate on leptomeningeal carcinomatosis in terms of symptomatic response and side effects. METHODS: Previous infusion rate of 20 mL/h...
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A Case of Autoimmune Sensorineural Hearing Loss Responding to Cytotoxic Agent

Lee YW, Lee J, Kim MB, Chang SO

Autoimmune sensorineural hearing loss is a rare disease characterized by bilateral sensorineural hearing loss, some in a progressive pattern and others in idiopathic or fluctuating pattern, often accompanied by vestibular...
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Delayed Elimination After High-dose Methotrexate in Pediatric Patients with Acute Lymphoblastic Leukemia and Non-Hodgkin Lymphoma

Yoon HW, Ree YS, Song HS, Kim JS, Son ES

BACKGROUND: High doses of methotrexate (MTX) are often used in various chemotherapy protocols to treat acute lymphoblastic leukemia (ALL) and non-Hodgkin's lymphoma (NHL) in children, but its delayed elimination increases...
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Primary Intraocular T-cell Lymphoma

Shin YI, Kim JM, Lee JJ, Kim JY, Kim J, Jo YJ

PURPOSE: Intraocular lymphoma can be divided into primary and secondary usually involving B-cell lymphoma. Intraocular T-cell lymphoma is mostly secondary lymphoma while primary intraocular T-cell lymphoma is extremely rare. We...
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Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis

Kang YM, Park YE, Park W, Choe JY, Cho CS, Shim SC, Bae SC, Suh CH, Cha HS, Koh EM, Song YW, Yoo B, Lee SS, Park MC, Lee SH, Arendt C, Koetse W, Lee SK

BACKGROUND/AIMS: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. METHODS:...
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Three Cases of Generalized Granuloma Annulare Successfully Treated with Methotrexate

Cheon SJ, Park S, Lee HJ, Kim T, Jin H, You H, Shim WH, Kim GW, Kim HS, Ko HC, Kim MB, Kim BS

  • KMID: 2436847
  • Korean J Dermatol.
  • 2018 Aug;56(7):437-442.
Granuloma annulare is a benign granulomatous skin disease, clinically characterized by dermal papules tending to form annular shapes. Granuloma annulare is classified into localized, generalized, subcutaneous, and perforating types. Localized...
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Ultrasound-guided local injection of methotrexate and systemic intramuscular methotrexate in the treatment of cesarean scar pregnancy

Kim YR, Moon MJ

OBJECTIVE: To assess the efficacy and safety of ultrasound-guided intragestational injection of methotrexate (MTX) and systemic intramuscular MTX in the management of cesarean scar pregnancies. METHODS: This was a retrospective case-control...
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