Clin Pediatr Hematol Oncol.  2014 Oct;21(2):177-180. 10.0000/cpho.2014.21.2.177.

Mucoepidermoid Carcinoma on Submandibular Salivary Gland as a Second Malignant Neoplasm after Treatment of Yolk Sac Tumor

• Keum HS
• Kang JI
• Yoo ES
• Park HJ
• Lee SW
• Ryu KH

• KMID: 2279832
• DOI: http://doi.org/10.0000/cpho.2014.21.2.177

Abstract

Malignant salivary gland tumors only represent 0.08% of all childhood tumors and mucoepidermoid carcinoma (MEC) is the most common histologic type. Although there are many reports describing second malignant neoplasm (SMN) in patients treated for childhood cancer, salivary gland tumors rarely appears. In Korea, there has been no report about MEC that developed in children as a SMN. We report a MEC in a 4 years and 8 months old female child that developed after completing treatment for yolk sac tumor of lower abdomen. The primary tumor presented with metastasis at the time of diagnosis, and therefore, the child underwent high-dose chemotherapy with autologous peripheral blood stem cell transplantation along with surgery and radiotherapy. Three years and five months after completing treatment, MEC developed in her submandibular gland. She was treated with surgery and radiotherapy and is in disease free state for 5 months at the time of this writing.

Keyword

Second malignant neoplasm; Mucoepidermoid carcinoma

MeSH Terms

Abdomen
Carcinoma, Mucoepidermoid*
Child
Diagnosis
Drug Therapy
Endodermal Sinus Tumor*
Female
Humans
Korea
Neoplasm Metastasis
Peripheral Blood Stem Cell Transplantation
Radiotherapy
Salivary Gland Neoplasms
Salivary Glands*
Submandibular Gland
Writing