Korean J Otorhinolaryngol-Head Neck Surg.  2012 Mar;55(3):173-176. 10.3342/kjorl-hns.2012.55.3.173.

A Case of Oncocytic Carcinoma Arising in the Submandibular Gland

• Shin SK
• Lee YO
• Lee BJ
• Lim YS

• KMID: 2277337
• DOI: http://doi.org/10.3342/kjorl-hns.2012.55.3.173

Abstract

Oncocytic neoplasm of the head and neck region accounts for approximately 1% of all salivary gland tumors, but only 5% of oncocytic neoplasm is malignant. Oncocytic carcinoma arising in the submandibular gland is exceedingly rare. We encountered a sixty seven-year-old male patient who presented with multiple mass in the right neck. Fine needle aspiration biopsy revealed a salivary gland tumor of predominantly oncocytic form, and a differential diagnosis included oncocytic adenoma or mucoepidermoid carcinoma. A right submandibular gland resection and modified radical neck dissection were performed. Histologically, the tumor cells showed nuclear pleomorphism, and stromal invasion, which were compatible with oncocytic carcinoma. After surgery, the entire neck region was irradiated. Seventeen months after the initial surgery, multiple metastases to the bone and lung were detected from the incidental pathologic bone fracture of the right humerus; palliative chemotherapy was performed to resolve this. We report a case of oncocytic carcinoma in the submandibular gland with a review of literature.

Keyword

Submandibular gland neoplasms; Lymphatic metastasis

MeSH Terms

Adenoma
Biopsy
Biopsy, Fine-Needle
Carcinoma, Mucoepidermoid
Diagnosis, Differential
Fractures, Bone
Head
Humans
Lung
Lymphatic Metastasis
Male
Neck
Neck Dissection
Neoplasm Metastasis
Salivary Glands
Submandibular Gland
Submandibular Gland Neoplasms