- Reprogramming of Cancer Cells into Induced Pluripotent Stem Cells Questioned
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Bang JS, Choi NY, Lee M, Ko K, Park YS, Ko K
- KMID: 2465883
- Int J Stem Cells.
- 2019 Nov;12(3):430-439.
- doi: 10.15283/ijsc19067
BACKGROUND AND OBJECTIVES: Several recent studies have claimed that cancer cells can be reprogrammed into induced pluripotent stem cells (iPSCs). However, in most cases, cancer cells seem to be resistant... -
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- Toward a Reconceptualization of Stem Cells from Cellular Plasticity
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Liu T, Chen L, Zhao Z, Zhang S
- KMID: 2447219
- Int J Stem Cells.
- 2019 Mar;12(1):1-7.
- doi: 10.15283/ijsc18096
The slow progress in clinical applications of stem cells and the bewildering mechanisms involved have puzzled many researchers. Recently, the increasing evidences have indicated that cells have superior plasticity in... -
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- Comparison of Reprogramming Methods for Generation of Induced-Oligodendrocyte Precursor Cells
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Lee EH, Park CH
- KMID: 2386901
- Biomol Ther.
- 2017 Jul;25(4):362-366.
- doi: 10.4062/biomolther.2017.066
Direct conversion by trans-differentiation is of growing interest in cell therapy for incurable diseases. The efficiency of cell reprogramming and functionality of converted cells are important considerations in cell transplantation... -
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- Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique
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Kim HJ, Jeong J, Park S, Jin YW, Lee SS, Lee SB, Choi D
- KMID: 2412193
- Gut Liver.
- 2017 Mar;11(2):261-269.
- doi: 10.5009/gnl15389
BACKGROUND/AIMS: Cancer is known to be a disease by many factors. However, specific results of reprogramming by pluripotency-related transcription factors remain to be scarcely reported. Here, we verified potential effects... -
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- Suppression of the ERK–SRF axis facilitates somatic cell reprogramming
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Huh S, Song HR, Jeong GR, Jang H, Seo NH, Lee JH, Yi JY, Lee B, Choi HW, Do JT, Kim JS, Lee SH, Jung JW, Lee T, Shim J, Han MK, Lee TH
- KMID: 2440030
- Exp Mol Med.
- 2018 Feb;50(2):e448.
- doi: 10.1038/emm.2017.279
The molecular mechanism underlying the initiation of somatic cell reprogramming into induced pluripotent stem cells (iPSCs) has not been well described. Thus, we generated single-cell-derived clones by using a combination... -
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- Hybrid Nanofiber Scaffold-Based Direct Conversion of Neural Precursor Cells/Dopamine Neurons
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Lim MS, Ko SH, Kim MS, Lee B, Jung HS, Kim K, Park CH
- KMID: 2465903
- Int J Stem Cells.
- 2019 Jul;12(2):340-346.
- doi: 10.15283/ijsc18123
The concept of cellular reprogramming was developed to generate induced neural precursor cells (iNPCs)/dopaminergic (iDA) neurons using diverse approaches. Here, we investigated the effects of various nanoscale scaffolds (fiber, dot,... -
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- Trans-differentiation via Epigenetics: A New Paradigm in the Bone Regeneration
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Cho YD, Ryoo HM
- KMID: 2406234
- J Bone Metab.
- 2018 Feb;25(1):9-13.
- doi: 10.11005/jbm.2018.25.1.9
In regenerative medicine, growing cells or tissues in the laboratory is necessary when damaged cells can not heal by themselves. Acquisition of the required cells from the patient's own cells... -
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- The Role of Microenvironment in Preserving the Potency of Adult Porcine Pulmonary Valve Stem Cells In Vitro
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Chalajour , Siyahian A, Hanley FL
- KMID: 2413508
- Int J Stem Cells.
- 2018 Jun;11(1):121-130.
- doi: 10.15283/ijsc18020
BACKGROUND AND OBJECTIVE: The potency of tissue resident stem cells is regulated primarily by inputs from the local microenvironment. Isolation of stem cells through enzymatic digestion of tissue may affect... -
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- Improved preimplantation development of porcine somatic cell nuclear transfer embryos by caffeine treatment
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Kim G, Roy PK, Fang X, Hassan BM, Cho J
- KMID: 2448715
- J Vet Sci.
- 2019 May;20(3):e31.
- doi: 10.4142/jvs.2019.20.e31
This study examined the effects of a caffeine treatment to improve nuclear reprogramming in porcine cloned embryos. Embryonic development and the expression of genes related to pluripotency (POU5F1, SOX2, NANOG,... -
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- MicroRNA-183 Family in Inner Ear: Hair Cell Development and Deafness
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Mahmoodian sani MR, Hashemzadeh-Chaleshtori M, Saidijam M, Jami MS, Ghasemi-Dehkordi P, Saidijam M, Jami MS
- KMID: 2361685
- J Audiol Otol.
- 2016 Dec;20(3):131-138.
- doi: 10.7874/jao.2016.20.3.131
miRNAs are essential factors of an extensively conserved post-transcriptional process controlling gene expression at mRNA level. Varoius biological processes such as growth and differentiation are regulated by miRNAs. Web of... -
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- Recent technological updates and clinical applications of induced pluripotent stem cells
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Diecke S, Jung SM, Lee J, Ju JH
- KMID: 1794617
- Korean J Intern Med.
- 2014 Sep;29(5):547-557.
- doi: 10.3904/kjim.2014.29.5.547
Induced pluripotent stem cells (iPSCs) were first described in 2006 and have since emerged as a promising cell source for clinical applications. The rapid progression in iPSC technology is still... -
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