- Identification and Characterization of Two New S-Adenosylmethionine-Dependent Methyltransferase Encoding Genes Suggested Their Involvement in Stipe Elongation of Flammulina velutipes
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Huang Q, Mukhtar I, Zhang Y, Wei Z, Han X, Huang R, Yan J, Xie B
- KMID: 2470176
- Mycobiology.
- 2019 Dec;47(4):441-448.
- doi: 10.1080/12298093.2019.1658332
Two new SAM-dependent methyltransferase encoding genes (fvsmt1 and fvsmt2) were identified from the genome of Flammulina velutipes. In order to make a comprehensive characterization of both genes, we performed in... -
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- An RNA Mapping Strategy to Identify Ribozyme-Accessible Sites on the Catalytic Subunit of Mouse Telomerase
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Song MS, Lee SW
- KMID: 2166253
- Genomics Inform.
- 2007 Mar;5(1):32-35.
Telomerase reverse transcriptase (TERT) is an enzymatic ribonucleoprotein that prolongs the replicative life span of cells by maintaining protective structures at the ends of eukaryotic chromosomes. Telomerase activity is highly... -
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- Radiotracer Methods for Targeted Imaging of the Epidermal Growth Factor Receptor
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Jung KH, Lee KH
- KMID: 2313040
- Nucl Med Mol Imaging.
- 2008 Jun;42(3):185-191.
While indirect targeting strategies using reporter-genes are taking center stage in current molecular imaging research, another vital strategy has long involved direct imaging of specific receptors using radiolabeled ligands. Recently,... -
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- Expression and Purification of Herpes Simplex Virus Type 1 Protease
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Bae PK, Paeng JW, Kim JH, Kim HS, Paik SG, Chung IK
- KMID: 1544249
- J Korean Soc Virol.
- 1999 Sep;29(3):175-182.
An attractive target for anti-herpes chemotherapy is the herpes simplex virus 1 (HSV-1) protease encoded by the UL26 gene. HSV-1 protease is essential for DNA packaging and virus maturation. To... -
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- Cloning and expression of trypsin-encoding cDNA from Blattella germanica and its possibility as an allergen
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Ock MS, Kim BJ, Kim SM, Byun KH
- KMID: 1720500
- Korean J Parasitol.
- 2005 Sep;43(3):101-110.
- doi: 10.3347/kjp.2005.43.3.101
In this study, the trypsin gene (bgtryp-1) from the German cockroach, Blattella germanica, was cloned via the immunoscreening of patients with allergies to cockroaches. Nucleotide sequence analysis predicted an 863... -
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- Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and beta-Ketoacyl Reductase Catalytic Domains
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John A, Umashankar V, Krishnakumar S, Deepa PR
- KMID: 2053332
- Genomics Inform.
- 2015 Mar;13(1):15-24.
- doi: 10.5808/GI.2015.13.1.15
Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to... -
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- Construction of an RNase P Ribozyme Library System for Functional Genomics Applications
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Hong SW, Choi HJ, Lee YH, Lee DK
- KMID: 2166248
- Genomics Inform.
- 2007 Mar;5(1):6-9.
An RNase P ribozyme library has been developed as a tool for functional genomics studies. Each clone of this library contains a random 18-mer and the sequence of M1 RNA,... -
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- The Role of PTEN Mutation in the Development of Endometrial Carcinoma
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Choi YD, Kim SS, Park CS, Nam JH
- KMID: 2172283
- Chonnam Med J.
- 2009 Apr;45(1):47-54.
- doi: 10.4068/cmj.2009.45.1.47
Over the past 2 decades, the tendency has been to classify endometrial carcinoma into 2 different types. Type I tumors (about 80%) are endometrioid carcinomas, are often preceded by complex... -
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- Telomerase: Key to Mortal or Immortal Road
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Yang EY, Sung YH, Lee HW
- KMID: 1974515
- Immune Netw.
- 2002 Dec;2(4):183-188.
- doi: 10.4110/in.2002.2.4.183
Gradual attrition of telomere to a critical short length elicits successive cellular response of cellular senescence and crisis. Cancer cells evade this process by maintaining functional telomeres via one of... -
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- Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes
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Hewage SR, Piao MJ, Kang KA, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Moon YJ, Shin DO, Hyun JW
- KMID: 2386910
- Biomol Ther.
- 2017 Jul;25(4):427-433.
- doi: 10.4062/biomolther.2016.112
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved... -
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- Modulation of ATP-induced activation of the muscarinic K+ channel activity by protein kinase C
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Kim YM, Park HK, Han JH, Park CO, Hong SG
- KMID: 2071833
- Korean J Physiol Pharmacol.
- 1998 Dec;2(6):743-753.
The atrial acetylcholine-activated K+ (KACh) channel is gated by the pertussis toxin-sensitive inhibitory G (GK) protein. Earlier studies revealed that ATP alone can activate the KACh channel via transphosphorylation mediated by nucleoside-diphosphate kinase... -
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- Inhibition of DNA-dependent Protein Kinase by Blocking Interaction between Ku Complex and Catalytic Subunit of DNA-dependent Protein Kinase
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Kim CH, Cuong DV, Kim JS, Kim N, Kim E, Han J
- KMID: 1607348
- Korean J Physiol Pharmacol.
- 2003 Feb;7(1):9-14.
Recent studies indicated that cancer cells become resistant to ionizing radiation (IR) and chemotherapy drugs by enhanced DNA repair of the lesions. Therefore, it is expected to increase the killing... -
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- Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA
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Lee JS
- KMID: 1522934
- Cancer Res Treat.
- 2007 Sep;39(3):116-124.
PURPOSE: Mutations in the ATM (ataxia-telangiectasia mutated) gene, which encodes a 370 kd protein with a kinase catalytic domain, predisposes people to cancers, and these mutations are also linked to... -
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- Garcinexanthone G, a Selective Butyrylcholinesterase Inhibitor from the Stem Bark of Garcinia atroviridis
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Khaw KY, Murugaiyah V, Khairuddean M, Tan WN
- KMID: 2416067
- Nat Prod Sci.
- 2018 Jun;24(2):88-92.
- doi: 10.20307/nps.2018.24.2.88
The present study was undertaken to investigate the isolated compounds from the stem bark of Garcinia atroviridis as potential cholinesterase inhibitors and the ligand-enzyme interactions of selected bioactive compounds in... -
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- p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest
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Chae HD, Kim SY, Park SE, Kim J, Shin DY
- KMID: 1245266
- Exp Mol Med.
- 2012 Mar;44(3):236-240.
- doi: 10.3858/emm.2012.44.3.018
We previously reported that the p53 tumor suppressor protein plays an essential role in the induction of tetraploid G1 arrest in response to perturbation of the actin cytoskeleton, termed actin... -
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- The Expression of Telomerase Reverse Transcriptase Protein is an Independent Prognostic Marker in Early Stage Non-Small Cell Lung Carcinomas
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Jung JH, Jung CK, Lee A, Park G, Yoo J, Lee KY
- KMID: 2073778
- Korean J Pathol.
- 2007 Apr;41(2):95-102.
BACKGROUND: The catalytic subunit of telomerase, hTERT (telomerase reverse transcriptase), is one of the most important components of telomerase, and performs a pivotal role in the mechanism underlying the regulation... -
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- Specific Expression of Aplysia Phosphodiesterase 4 in Bag Cells Revealed by in situ Hybridization Analysis
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Jang DJ, Kim HF, Sim JH, Lim CS, Kaang BK
- KMID: 2165561
- Exp Neurobiol.
- 2015 Sep;24(3):246-251.
- doi: 10.5607/en.2015.24.3.246
Phosphodiesterases (PDEs) play a key role in the regulation of cyclic adenosine monophosphate (cAMP), which in turn mediates various cellular functions including learning and memory. We previously cloned and characterized... -
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- Functional identification of protein phosphatase 1-binding consensus residues in NBCe1-B
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Lee KP, Kim HJ, Yang D
- KMID: 2398559
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):91-99.
- doi: 10.4196/kjpp.2018.22.1.91
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B.... -
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- In Situ Detection of mRNA and RNA Component of Human Telomerase in Proliferative Lesions of the Stomach
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Kim MS, Juhng SW
- KMID: 1725817
- Korean J Pathol.
- 2001 Aug;35(4):299-305.
BACKGROUND: Proliferative lesions of the stomach were investigated by in situ hybridization using RNA probes for telomerase components and compared with the results by TRAP (telomeric repeat amplification protocol) assay.... -
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- Overexpression of AMPKalpha1 Ameliorates Fatty Liver in Hyperlipidemic Diabetic Rats
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Seo E, Park EJ, Joe Y, Kang S, Kim MS, Hong SH, Park MK, Kim DK, Koh H, Lee HJ
- KMID: 2285380
- Korean J Physiol Pharmacol.
- 2009 Dec;13(6):449-454.
- doi: 10.4196/kjpp.2009.13.6.449
5'-AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic (alpha) and two regulatory (beta and gamma) subunits. Two isoforms are known for catalytic subunit (alpha1, alpha2) and... -
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