- Ribonucleotide Reductase Subunit M2 Can Be New Molecular Target and Prognostic Biomarker of Hepatocellular Carcinoma
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Kim HY, Kim CW
- KMID: 2070072
- Gut Liver.
- 2014 Nov;8(6):580-581.
- doi: 10.5009/gnl14377
No abstract available. -
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- High Expression of Ribonucleotide Reductase Subunit M2 Correlates with Poor Prognosis of Hepatocellular Carcinoma
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Lee B, Ha SY, Song DH, Lee HW, Cho SY, Park CK
- KMID: 2070085
- Gut Liver.
- 2014 Nov;8(6):662-668.
- doi: 10.5009/gnl13392
BACKGROUND/AIMS: Ribonucleotide reductase subunit M2 (RRM2) catalyzes the production of deoxynucleotide triphosphates, which are necessary for DNA synthesis. RRM2 has been reported to play an active role in tumor progression,... -
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- Hepatocyte Expressions in Hepatocellular Carcinomas, Gastrointestinal Neoplasms, and Non-neoplastic Gastrointestinal Mucosa: its Role as a Diagnostic Marker
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Lee HS, Kim WH, Kang GH
- KMID: 1086741
- J Korean Med Sci.
- 2003 Dec;18(6):842-848.
- doi: 10.3346/jkms.2003.18.6.842
We performed immunohistochemical staining against Hepatocyte (Hep) and CD10 antibodies in 75 hepatocellular carcinoma (HCC), 50 cholangiocarcinomas, 49 colorectal adenocarcinomas, and 308 gastric adenocarcinomas by tissue array method. We also... -
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- High Expression of Aldo-Keto Reductase 1B10 Is an Independent Predictor of Favorable Prognosis in Patients with Hepatocellular Carcinoma
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Ha SY, Song DH, Lee JJ, Lee HW, Cho SY, Park CK
- KMID: 2070083
- Gut Liver.
- 2014 Nov;8(6):648-654.
- doi: 10.5009/gnl13406
BACKGROUND/AIMS: Upregulation of aldo-keto reductase 1B10 (AKR1B10) through the mitogenic activator protein-1 signaling pathway might promote hepatocarcinogenesis and tumor progression. The goal of this study was to evaluate the prognostic... -
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- A Case of Granulocyte-Colony Stimulating Factor-Producing Hepatocellular Carcinoma Confirmed by Immunohistochemistry
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Joshita S, Nakazawa K, Koike S, Kamijo A, Matsubayashi K, Miyabayashi H, Furuta K, Kitano K, Yoshizawa , Tanaka E
- KMID: 1778047
- J Korean Med Sci.
- 2010 Mar;25(3):476-480.
- doi: 10.3346/jkms.2010.25.3.476
Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing... -
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- Expressions of HSP70 and HSP27 in Hepatocellular Carcinoma
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Joo M, Chi JG, Lee H
- KMID: 1781767
- J Korean Med Sci.
- 2005 Oct;20(5):829-834.
- doi: 10.3346/jkms.2005.20.5.829
The heat shock proteins (HSPs) are ubiquitous molecules induced in cells exposed to various stress conditions, including carcinogenesis. The HSP70 and HSP27 among HSPs are of special relevance in human... -
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- Cyclooxygenase-2 and vascular endothelial growth factor in chronic hepatitis, cirrhosis and hepatocellular carcinoma
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Kwon SH, Jeong SW, Jang JY, Lee JE, Lee SH, Kim SG, Kim YS, Cho YD, Kim HS, Kim BS, Jin SY
- KMID: 1392908
- Clin Mol Hepatol.
- 2012 Sep;18(3):287-294.
- doi: 10.3350/cmh.2012.18.3.287
BACKGROUND/AIMS: Cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) are up-regulated in hepatocellular carcinoma (HCC). To investigate the levels of COX-2 and VEGF expression in chronic hepatitis (CH), cirrhosis, and... -
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- beta-Catenin Activated Hepatocellular Adenoma: A Report of Three Cases in Korea
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Kim GJ, Seok JY, Rhee H, Choi JY, Choi JS, Kim KS, Thung S, Park YN
- KMID: 1792371
- Gut Liver.
- 2014 Jul;8(4):452-458.
Hepatocellular adenoma (HCA) is an uncommon benign hepatic tumor, and the use of oral contraceptives is known to contribute to the development of HCA. Recently, a genotype and phenotype classification... -
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- Histamine and spontaneously released mast cell granules ffect the cell growth of human hepatocellular carcinoma cells
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Lampiasi N, Azzolina A, Montalto G, Cervello M
- KMID: 1047079
- Exp Mol Med.
- 2007 Jun;39(3):284-294.
The role of mast cells in tumor growth is still controversial. In this study we analyzed the effects of both histamine and pre-formed mediators spontaneously released by mast cells on... -
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- Prognostic Significance of p53 Overexpression after Hepatic Resection of Hepatocellular Carcinoma
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Sung CO, Yoo BC, Koh KC, Cho JW, Park CK
- KMID: 772790
- Korean J Gastroenterol.
- 2005 Jun;45(6):425-430.
BACKGROUND/AIMS: p53 mutation is the most common genetic abnormality in human cancers. However, although it has been reported that p53 overexpression in hepatocellular carcinoma (HCC) is associated with the... -
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- Co-expression patterns of Notch1, Snail, and p53 in grade III hepatocellular carcinoma with postoperative recurrence: a preliminary study
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Jang SK, Choi GH, Choi J, Quan X, Jang JW, Kim BH, Jung G, Park YM
- KMID: 1372653
- Korean J Hepatol.
- 2012 Mar;18(1):63-74.
- doi: 10.3350/kjhep.2012.18.1.63
BACKGROUND/AIMS: We aimed to determine the association between the co-expression patterns of Notch1, Snail, and p53 proteins (NSP) and the postoperative prognosis of hepatocellular carcinoma (HCC). METHODS: The immunoblot data for... -
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- Prognostic Significance of p53, mTOR, c-Met, IGF-1R, and HSP70 Overexpression after the Resection of Hepatocellular Carcinoma
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Kang GH, Lee BS, Lee ES, Kim SH, Lee HY, Kang DY
- KMID: 1774532
- Gut Liver.
- 2014 Jan;8(1):79-87.
BACKGROUND/AIMS: The current study examines the expression of molecular biomarkers in hepatocellular carcinoma (HCC) and whether these findings correlate with the clinicopathologic features of the disease and patient survival. METHODS: We... -
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- Could HBx Protein Expression Affect Signal Pathway Inhibition by Gefitinib or Selumetinib, a MEK Inhibitor, in Hepatocellular Carcinoma Cell Lines?
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Park YK, Kim KM, Lee YJ, Kim KH, Lee SG, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS, Suh DJ
- KMID: 1782109
- J Korean Med Sci.
- 2011 Feb;26(2):214-221.
- doi: 10.3346/jkms.2011.26.2.214
Hepatitis B virus X (HBx) protein has been known to play an important role in development of hepatocellular carcinoma (HCC). The aim of this study is to find out whether... -
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- Expression Patterns of E-cadherin and beta-catenin According to Clinicopathological Characteristics of Hepatocellular Carcinoma
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Bae SH, Jung ES, Park YM, Jang JW, Choi JY, Cho SH, Yoon SK, Ahn BM, Cha SB, Chung KW, Sun HS, Park DH, Kim BK, Kim DG
- KMID: 863100
- Korean J Hepatol.
- 2002 Sep;8(3):297-303.
BACKGROUND/AIMS: E-cadherin is involved in intercellular binding and cellular polarity formation. beta-catenin plays a fundamental role in regulation of the E-cadherin cell adhesion complex. The abnormalities of the components... -
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- Silencing of KIF14 interferes with cell cycle progression and cytokinesis by blocking the p27(Kip1) ubiquitination pathway in hepatocellular carcinoma
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Xu H, Choe C, Shin SH, Park SW, Kim HS, Jung SH, Yim SH, Kim TM, Chung YJ
- KMID: 2155362
- Exp Mol Med.
- 2014 May;46(5):e97.
- doi: 10.1038/emm.2014.23
Although it has been suggested that kinesin family member 14 (KIF14) has oncogenic potential in various cancers, including hepatocellular carcinoma (HCC), the molecular mechanism of this potential remains unknown. We... -
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- The Effects of Tamoxifen on Human Hepatocelluar Carcinoma Cell Proliferation and Transforming Growth Factor-beta1 Expression
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Shin JW, Chung YH, Park MI, Kim JA, Choi MH, Lee YJ, Ryu SH, Park NH, Lee HC, Lee YS, Suh DJ, Yu ES
- KMID: 1011390
- Korean J Hepatol.
- 2003 Mar;9(1):10-16.
BACKGROUND/AIMS: Tamoxifen has been tried in patients with hepatocellular carcinoma (HCC), however, its inhibitory mechanism remains unknown. In this study, we evaluated the effects of tamoxifen on HCC cell... -
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- Down-Regulation of TGF-β Expression Sensitizes the Resistance of Hepatocellular Carcinoma Cells to Sorafenib
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Kang D, Han Z, Oh GH, Joo Y, Choi HJ, Song JJ
- KMID: 2418924
- Yonsei Med J.
- 2017 Sep;58(5):899-909.
- doi: 10.3349/ymj.2017.58.5.899
PURPOSE: Sorafenib, a multikinase inhibitor, is the standard therapy for patients with advanced-stage hepatocellular carcinoma (HCC). However, resistance develops to the treatment, therefore, we tried to unravel the underlying mechanism... -
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- Association between apolipoprotein E genotype, chronic liver disease, and hepatitis B virus
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Ahn SJ, Kim DK, Kim SS, Bae CB, Cho HJ, Kim HG, Kim YJ, Lee JH, Lee HJ, Lee MY, Kim KB, Cho JH, Cho SW, Cheong JY
- KMID: 1392909
- Clin Mol Hepatol.
- 2012 Sep;18(3):295-301.
- doi: 10.3350/cmh.2012.18.3.295
BACKGROUND/AIMS: Apolipoprotein E (ApoE) plays an important role in regulating lipid and lipoprotein metabolism, and ApoE genotypes are known to affect plasma lipoprotein concentrations. We investigated whether ApoE genotype determines... -
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- Growth promotion of HepG2 hepatoma cells by antisense-mediated knockdown of glypican-3 is independent of insulin-like growth factor 2 signaling
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Sung YK, Hwang SY, Farooq M, Kim JC, Kim MK
- KMID: 1109313
- Exp Mol Med.
- 2003 Aug;35(4):257-262.
Glypican-3 (GPC3) encodes a cell-surface heparan-sulfate proteoglycan and its expression is frequently silenced in ovarian cancer, mesotheliomas, and breast cancer cell lines and ectopic expression of GPC3 inhibited the growth... -
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- Expression Patterns of Cytokines and Chemokines Genes in Human Hepatoma Cells
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Shin EC, Choi YH, Kim JS, Kim SJ, Park JH
- KMID: 1728861
- Yonsei Med J.
- 2002 Oct;43(5):657-664.
- doi: 10.3349/ymj.2002.43.5.657
Various cytokines and chemokines play a role in carcinogenesis. However, no study has previously been undertaken to investigate comprehensively the expressions of cytokines and chemokines in hepatoma cells. In this... -
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