Gut Liver.
2014 Jul;8(4):452-458.
beta-Catenin Activated Hepatocellular Adenoma: A Report of Three Cases in Korea
- Affiliations
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- 1Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. young0608@yuhs.ac
- 2Department of Pathology, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.
- 3Department of Radiology, Research Institute of Radiological Science, Yonsei University Severance Hospital, Seoul, Korea.
- 4Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
- 5Department of Pathology, The Mount Sinai Medical Center, New York, NY, USA.
Abstract
- Hepatocellular adenoma (HCA) is an uncommon benign hepatic tumor, and the use of oral contraceptives is known to contribute to the development of HCA. Recently, a genotype and phenotype classification system for HCA was suggested, and malignant transformation to hepatocellular carcinoma (HCC) was shown to be strongly associated with activating mutations in beta-catenin. Here, we report three cases of HCA in Korean patients: 7-cm, inflammatory and beta-catenin-activated HCA with HCC transformation in a 46-year-old man; 13-cm, beta-catenin-activated HCA with cytological atypia in a 23-year-old woman; and 10-cm, pigmented, inflammatory and beta-catenin-activated HCA in a 36-year-old man. All cases exhibited the nuclear expression of beta-catenin and diffuse cytoplasmic expression of glutamine synthetase upon immunohistochemical staining. All tumors were completely resected, and the patients were followed for 3 to 6 years with no evidence of local recurrence or metastasis.
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