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Public Attitudes towards Cancer Survivors among Korean Adults

Kye SY, Lee HJ, Lee Y, Kim YA

Purpose We evaluated public attitudes towards cancer survivors and identified the characteristics associated with these attitudes in Korea. Materials and Methods We performed this cross-sectional study using proportionate quota random sampling of the...
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Socioeconomic Burden of Cancer in Korea from 2011 to 2015

Kim YA, Lee YR, Park J, Oh IH, Kim H, Yoon SJ, Park K

Purpose Though the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed...
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Omega-3 and -6 Fatty Acid Intake and Colorectal Cancer Risk in Swedish Women’s Lifestyle and Health Cohort

Shin A, Cho S, Sandin S, Lof M, Oh MY, Weiderpass E

Purpose We aimed to assess the association between the dietary intake of fish-derived omega-3 polyunsaturated fatty acids and the risk of colorectal cancer among Swedish women. Materials and Methods A total of 48,233...
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Comparing the Characteristics and Outcomes of Male and Female Breast Cancer Patients in Korea: Korea Central Cancer Registry

Lee EG, Jung SY, Lim MC, Lim J, Kang HS, Lee S, Han JH, Jo H, Won YJ, Lee ES

Purpose This study aimed to determine the incidence of male breast cancer (MBC) and its survival outcomes in Korea, and to compare these results to those for female breast cancer (FBC). Materials...
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Laparoscopic Surgery for Colorectal Cancer in Korea: Nationwide Data from 2013 to 2018

Park SJ, Lee KY, Lee SH

Purpose We report nationwide data on the current status of laparoscopic surgery for colorectal cancer (CRC) in Korea. Materials and Methods Nationwide data of patients who underwent surgery for CRC from 2013 to...
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Detection of Germline Mutations in Breast Cancer Patients with Clinical Features of Hereditary Cancer Syndrome Using a Multi-Gene Panel Test

Shin HC, Lee HB, Yoo TK, Lee ES, Kim RN, Park B, Yoon KA, Park C, Lee ES, Moon HG, Noh DY, Kong SY, Han W

Purpose Hereditary cancer syndrome means that inherited genetic mutations can increase a person's risk of developing cancer. We assessed the frequency of germline mutations using an nextgeneration sequencing (NGS)–based multiple-gene panel...
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Choosing Wisely: The Korean Perspective and Launch of the ‘Right Decision in Cancer Care’ Initiative

Kim JY, Lee KE, Kim K, Lee MA, Yoon WS, Han DS, Ahn SG, Kang JH

Government healthcare expenditure is rising in Korea, and the costs incurred by patients in Korea exceed those incurred by patients in other Organization for Economic Co-operation and Development countries. Despite...
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Clinical Implications of Circulating Tumor DNA from Ascites and Serial Plasma in Ovarian Cancer

Han MR, Lee SH, Park JY, Hong H, Ho JY, Hur SY, Choi YJ

Purpose The purpose of this study was to identify the clinical utility of circulating tumor DNA (ctDNA) from ascites and serial plasma samples from epithelial ovarian cancer (EOC) patients. Materials and Methods Using...
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Inhibition of ATR Increases the Sensitivity to WEE1 Inhibitor in Biliary Tract Cancer

Nam AR, Jin MH, Bang JH, Oh KS, Seo HR, Oh DY, Bang YJ

Purpose Currently, the DNA damage response (DDR) pathway represents a key target for new cancer drug development. Advanced biliary tract cancer (BTC) has a poor prognosis because of the lack of...
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PIK3CA H1047R Mutation Associated with a Lower Pathological Complete Response Rate in Triple-Negative Breast Cancer Patients Treated with Anthracycline-Taxane–Based Neoadjuvant Chemotherapy

Guo S, Loibl S, von Minckwitz G, Darb-Esfahani S, Lederer B, Denkert C

Purpose PIK3CA, encoding for subunit p110a of phosphatidylinositol 3 kinase, is frequently mutated in breast cancer. PIK3CAmutation was predictive for pathological complete response (pCR) in human epidermal growth factor 2 positive...
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Long Non-coding RNA CCAT1 Sponges miR-454 to Promote Chemoresistance of Ovarian Cancer Cells to Cisplatin by Regulation of Surviving

Wang DY, Li N, Cui YL

Purpose Colon cancer-associated transcript 1 (CCAT1) was identified as an oncogenic long non-coding RNA (lncRNA) in a variety of cancers. However, there was a lack of understanding of the mechanism by...
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Activation of β2-Adrenergic Receptor Promotes Growth and Angiogenesis in Breast Cancer by Down-regulating PPARγ

Zhou J, Liu Z, Zhang L, Hu X, Wang Z, Ni H, Wang Y, Qin J

Purpose Chronic stress and related hormones are key in cancer progression. Peroxisome proliferator-activated receptor γ (PPARγ) and its agonists was reported that inducing anti-tumor effect. However, the function of PPARγ in...
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Clinical Implication of Concordant or Discordant Genomic Profiling between Primary and Matched Metastatic Tissues in Patients with Colorectal Cancer

Choi JY, Choi S, Lee M, Park YS, Sung JS, Chang WJ, Kim JW, Choi YJ, Kim J, Kim DS, Lee SH, Seok J, Park KH, Kim SH, Kim YH

Purpose The purpose of this study was to identify the concordant or discordant genomic profiling between primary and matched metastatic tumors in patients with colorectal cancer (CRC) and to explore the...
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Clinicopathological Features of Patients with the BRCA1 c.5339T>C (p.Leu1780Pro) Variant

Park HS, Ryu JM, Park JS, Im SA, Jung SY, Kim EK, Park WC, Min JW, Lee J, You JY, Lee JE, Kim SW

Purpose Recent studies revealed the BRCA1 c.5339T>C, p.Leu1780Pro variant (L1780P) is highly suggested as a likely pathogenic. The aim of this study was to evaluate clinicopathologic features of L1780P with breast...
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RON and MET Co-overexpression Are Significant Pathological Characteristics of Poor Survival and Therapeutic Targets of Tyrosine Kinase Inhibitors in Triple-Negative Breast Cancer

Weng TH, Yao MY, Xu XM, Hu CY, Yao SH, Liu YZ, Wu ZG, Tang TM, Fu PF, Wang MH, Yao HP

Purpose Triple-negative breast cancer (TNBC) is highly malignant and has poor prognosis and a high mortality rate. The lack of effective therapy has spurred our investigation of new targets for...
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Caspase Recruitment Domain Containing Protein 9 Suppresses Non-Small Cell Lung Cancer Proliferation and Invasion via Inhibiting MAPK/p38 Pathway

Pan L, Tan Y, Wang B, Qiu W, Yin Y, Ge H, Zhu H

Purpose Caspase recruitment domain containing protein 9 (CARD9) has been demonstrated to be a pro-tumor factor in various cancers. However, our previous study found a significant decrease of CARD9 in malignant...
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Establishment and Validation of a Nomogram for Nasopharyngeal Carcinoma Patients Concerning the Prognostic Effect of Parotid Lymph Node Metastases

Lin C, Sun XS, Liu SL, Li XY, Lu N, Li XL, Tang LQ, Guo L

Purpose The prognosis of nasopharyngeal carcinoma (NPC) patients with parotid lymph node (PLN) metastasis remains unclear. This study was performed to investigate the prognostic significance and optimal staging category of...
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Prognostic Predictability of American Joint Committee on Cancer 8th Staging System for Perihilar Cholangiocarcinoma: Limited Improvement Compared with the 7th Staging System

Lee JW, Lee JH, Park Y, Lee W, Kwon J, Song KB, Hwang DW, Kim SC

Purpose This study was conducted to evaluate the prognostic values of the 7th and 8th American Joint Committee on Cancer (AJCC) staging systems for patients with resected perihilar cholangiocarcinoma (PHCC). Materials and...
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Implication of the Life-Sustaining Treatment Decisions Act on End-of-Life Care for Korean Terminal Patients

Kim JS, Yoo SH, Choi W, Kim Y, Hong J, Kim MS, Park HY, Keam B, Heo DS

Purpose Life-sustaining treatment (LST) decisions for patients and caregivers at the end-of-life (EOL) process are supported by the “Act on Hospice and Palliative Care and Decisions on LST for Patients at...
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Philadelphia+ Chronic Myeloid Leukemia with CALR Mutation: A Case Report and Literature Review

Yoon SY, Jeong SY, Kim C, Lee MY, Kim J, Kim KH, Lee N, Won JH

Myeloproliferative neoplasms (MPNs) are classified as chronic myeloid leukemia (CML) and Philadelphia chromosome-negative MPN. In MPN cases, the presence of a BCR-ABL1 translocation with a coexisting mutation is exceptionally rare....
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