- Melatonin Induces Apoptotic Cell Death via p53 in LNCaP Cells
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Kim CH, Yoo YM
- KMID: 2071707
- Korean J Physiol Pharmacol.
- 2010 Dec;14(6):365-369.
- doi: 10.4196/kjpp.2010.14.6.365
In this study, we examined whether melatonin promotes apoptotic cell death via p53 in prostate LNCaP cells. Melatonin treatment significantly curtailed the growth of LNCaP cells in a dose- and... -
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- Matrix Metalloproteinase-2 Expression of the Injured Anterior Cruciate Ligament in the Knee and Changes in Relation to Signal Transduction Pathways
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Lee HS, Kwon JY, Woo YK
- KMID: 2199064
- J Korean Orthop Res Soc.
- 2008 Oct;11(2):64-71.
PURPOSE: This study was designed to pursue the basic relationship between MMP-2 and ligament injury via ex vivo stretching of the anterior cruciate ligament (ACL) and its changes by signal... -
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- The Protective Effect of Eupatilin against Hydrogen Peroxide-Induced Injury Involving 5-Lipoxygenase in Feline Esophageal Epithelial Cells
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Lim JC, Park SY, Nam Y, Nguyen TT, Sohn UD
- KMID: 1493963
- Korean J Physiol Pharmacol.
- 2012 Oct;16(5):313-320.
- doi: 10.4196/kjpp.2012.16.5.313
In this study, we focused to identify whether eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone), an extract from Artemisia argyi folium, prevents H2O2-induced injury of cultured feline esophageal epithelial cells. Cell viability was measured by... -
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- IL-10 Inihibits VEGF Production in the Synovial Fibroblasts of RA Patients via Down-regulation of the ERK and AP-1 Pathways
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Lee SY, Cho ML, Park MK, Oh HJ, Park SH, Kim HY
- KMID: 2334866
- J Korean Rheum Assoc.
- 2009 Sep;16(3):213-222.
OBJECTIVE: Interleukin (IL)-10 has been demonstrated to have anti-inflammatory and anti-tumour activity. Because aberrant angiogenesis is a significant pathogenic component of tumor growth and chronic inflammation, we investigated the effect... -
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- Theaflavin Inhibits LPS-Induced IL-6, MCP-1, and ICAM-1 Expression in Bone Marrow-Derived Macrophages Through the Blockade of NF-kappaB and MAPK Signaling Pathways
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Kim S, Joo YE
- KMID: 2048793
- Chonnam Med J.
- 2011 Aug;47(2):104-110.
- doi: 10.4068/cmj.2011.47.2.104
Theaflavin, the main polyphenol in black tea, has anti-inflammatory, antioxidative, anti-mutagenic, and anti-carcinogenic properties. The aim of this study was to evaluate the effects of theaflavin on lipopolysaccharide (LPS)-induced innate... -
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- Signaling Pathway of Lysophosphatidic Acid-Induced Contraction in Feline Esophageal Smooth Muscle Cells
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Nam YS, Suh JS, Song HJ, Sohn UD
- KMID: 1429385
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):139-147.
- doi: 10.4196/kjpp.2013.17.2.139
Lysolipids such as LPA, S1P and SPC have diverse biological activities including cell proliferation, differentiation, and migration. We investigated signaling pathways of LPA-induced contraction in feline esophageal smooth muscle cells.... -
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- Induction of Inducible Nitric Oxide Synthase Expression by Manganese in C6 Glioma Cells
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Yu GI, Lee DH, Chung IS, Lee MY, Shin DH
- KMID: 1475121
- Korean J Occup Environ Med.
- 2009 Sep;21(3):259-266.
OBJECTIVE: It is well established that manganese neurotoxicity is associated with clinical symptoms similar to those of idiopathic Parkinson's disease. Recent research has shown that the exposure to manganese (MnCl2)... -
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- Ginsenoside Rg2 Inhibits Lipopolysaccharide-Induced Adhesion Molecule Expression in Human Umbilical Vein Endothelial Cell
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Cho YS, Kim CH, Ha TS, Lee SJ, Ahn HY
- KMID: 1429384
- Korean J Physiol Pharmacol.
- 2013 Apr;17(2):133-137.
- doi: 10.4196/kjpp.2013.17.2.133
Vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), P- and E-selectin play a pivotal role for initiation of atherosclerosis. Ginsenoside, a class of steroid glycosides, is abundant... -
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- Triptolide Inhibits the Proliferation of Immortalized HT22 Hippocampal Cells Via Persistent Activation of Extracellular Signal-Regulated Kinase-1/2 by Down-Regulating Mitogen-Activated Protein Kinase Phosphatase-1 Expression
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Koo HS, Kang SD, Lee JH, Kim NH, Chung HT, Pae HO
- KMID: 2066699
- J Korean Neurosurg Soc.
- 2009 Oct;46(4):389-396.
- doi: 10.3340/jkns.2009.46.4.389
OBJECTIVE: Triptolide (TP) has been reported to suppress the expression of mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1), of which main function is to inactivate the extracellular signal-regulated kinase-1/2 (ERK-1/2), the... -
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- Prodrug-activating Gene Therapy with Rabbit Cytochrome P450 4B1/4-Ipomeanol or 2-Aminoanthracene System in Glioma Cells
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Jang SJ, Kang JH, Lee TS, Kim SJ, Kim KI, Lee YJ, Cheon GJ, Choi CW, Lim SM
- KMID: 1455395
- Nucl Med Mol Imaging.
- 2010 Sep;44(3):193-198.
OBJECTIVE: We determined the cytotoxic properties of cytochrome P450 4B1 (CYP4B1) activated 4-ipomeanol (4-ipo) and 2-aminoanthracene (2-AA) in rat glioma to verify the CYP4B1/4-ipo or 2-AA system for prodrug-activating gene... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- SP600125, a selective JNK inhibitor, aggravates hepatic ischemia-reperfusion injury
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Lee KH, Kim SE, Lee YS
- KMID: 1110125
- Exp Mol Med.
- 2006 Aug;38(4):408-416.
c-Jun N-terminal kinase (JNK) is activated during hepatic reperfusion, and JNK inhibitors are known to protect other major organs from ischemia-reperfusion (I/R) injury. We attempted to determine the effect of... -
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- Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death
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Gong X, Wang M, Tashiro SI, Onodera S, Ikejima T
- KMID: 1110127
- Exp Mol Med.
- 2006 Aug;38(4):428-434.
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor... -
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- Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells
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Gong X, Wang M, Wu Z, Tashiro SI, Onodera S, Ikejima T
- KMID: 1103322
- Exp Mol Med.
- 2004 Dec;36(6):551-556.
Pseudolaric acid B was isolated from Pseudolarix kaempferi Gordon (Pinaceae) and was evaluated for the anti-cancer effect in HeLa cells. We observed that pseudolaric acid B inhibited cell proliferation and... -
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- Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells
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Kim YS, Jhon DY, Lee KY
- KMID: 1380210
- Exp Mol Med.
- 2004 Apr;36(2):157-164.
Selenium is a dietary essential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling... -
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- Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin
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Min BW, Kim CG, Ko J, Lim Y, Lee YH, Shin SY
- KMID: 1072950
- Exp Mol Med.
- 2008 Dec;40(6):699-708.
- doi: 10.3858/emm.2008.40.6.699
Expression of protein kinase C-delta (PKC delta) is up-regulated by apoptosis-inducing stimuli. However, very little is known about the signaling pathways that control PKC delta gene transcription. In the present... -
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- House Dust Mite Induces Expression of Intercellular Adhesion Molecule-1 in EoL-1 Human Eosinophilic Leukemic Cells
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Kwon BC, Sohn MH, Kim KW, Kim ES, Kim KE, Shin MH
- KMID: 1713286
- J Korean Med Sci.
- 2007 Oct;22(5):815-819.
- doi: 10.3346/jkms.2007.22.5.815
The house dust mite (HDM) is considered to be the most common indoor allergen associated with bronchial asthma. In this study, we investigated whether crude extract of the HDM Dermatophagoides... -
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- In vivo alternative testing with zebrafish in ecotoxicology
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Seok SH, Baek MW, Lee HY, Kim DJ, Na YR, Noh KJ, Park SH, Lee HK, Lee BH, Park JH
- KMID: 1104909
- J Vet Sci.
- 2008 Dec;9(4):351-357.
- doi: 10.4142/jvs.2008.9.4.351
Although rodents have previously been used in ecotoxicological studies, they are expensive, time-consuming, and are limited by strict legal restrictions. The present study used a zebrafish (Danio rerio) model and... -
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- Regulation of expression of matrix metalloproteinase-9 by JNK in Raw 264.7 cells: presence of inhibitory factor(s) suppressing MMP-9 induction in serum and conditioned media
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Lee YS, Lan Tran H, Van Ta Q
- KMID: 1088601
- Exp Mol Med.
- 2009 Apr;41(4):259-268.
- doi: 10.3858/emm.2009.41.4.029
Matrix metalloproteinase-9 (MMP-9) secreted from macrophages plays an important role in tissue destruction and inflammation through degradation of matrix proteins and proteolytic activation of cytokines/chemokines. Whereas the MEK-ERK and PI3K-Akt... -
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- Cytosolic accumulation of gammaH2AX is associated with tropomyosin-related kinase A-induced cell death in U2OS cells
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Jung EJ, Kim CW, Kim DR
- KMID: 756329
- Exp Mol Med.
- 2008 Jun;40(3):276-285.
- doi: 10.3858/emm.2008.40.3.276
Tropomyosin-related kinase A (TrkA) plays an important role in cell survival, differentiation, and apoptosis in various neuronal and nonneuronal cell types. Here we show that TrkA overexpression by the Tet-On... -
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