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Intrahepatic cholangiocarcinoma: Evolving role of neoadjuvant and targeted therapy

Ghio M, Vijay A

Intrahepatic cholangiocarcinoma is an aggressive, often fatal, malignancy that arises from the bile ducts. As it often presents with metastatic disease, surgery has limited utility. However, in some cases, neoadjuvant...
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How to achieve the critical view of safety for safe laparoscopic cholecystectomy: Technical aspects

Gupta V

Laparoscopic cholecystectomy is associated with a higher incidence of biliary/vasculobiliary injuries than open cholecystectomy. Anatomical misperception is the most common underlying mechanism of such injuries. Although a number of strategies have...
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External pancreatic ductal stenting in minimally invasive pancreatoduodenectomy: How to do it?

Gurram RP, L HS, Gnanasekaran S, Choudhury SR, Pottakkat B, Raja K

It has been shown that external pancreatic ductal stenting (EPDS) can reduce the incidence of clinically relevant postoperative pancreatic fistula. Although studies have described EPDS in open pancreaticoduodenectomy (PD), EPDS...
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Serous cystic neoplasm: Do we have to wait till it causes trouble? Season 2

Shin MC, Yang HY, Kim JS, Kang CM

A 50-year-old male presented gradually growing pancreatic body mass. An abdominal computed tomography showed a 9.9-cm mass, larger than the 8.9-cm mass one year ago. As the patient did not...
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Collective review of pancreatic carcinosarcoma, a very rare pancreatic malignancy

Lee M, Cho YJ, Jung HS, Yun WG, Han Y, Kwon W, Jang JY

Pancreatic carcinosarcoma is a very rare malignancy with a poor prognosis. Because of these characteristics, a treatment strategy for it has not been established yet. The aim of this study...
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Radical surgery for stage IV gallbladder cancers: Treatment strategies in patients with limited metastatic burden

Patkar S, Patel S, Kazi M, Goel M

Backgrounds/Aims: The present study looked at the role of radical surgery in gallbladder cancers (GBC) with limited metastatic disease. Methods: The retrospective observational study was conducted to screen the database from...
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Duplicated extrahepatic bile duct (type Vb): An important rare anomaly

Varshney VK, Hussain S, Vignesh N, Selvakumar B, Agarwal L, Yadav T

Congenital duplication of the extrahepatic bile duct (DEBD) is an unusual anomaly of the biliary system. It occurs due to inability of the embryological duplex biliary system to regress. DEBD...
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Systematic intraoperative cholangiography during elective laparoscopic cholecystectomy: Is it a justifiable practice?

Esposito F, Scoleri I, Cattan R, Cook MC, Sacrieru D, Meziani N, Prete MD, Kabbej M

Backgrounds/Aims: Routine execution of intraoperative cholangiography (IOC) in laparoscopic cholecystectomy (LC) is considered a good practice to help early identification of biliary duct injuries (BDIs) or common bile duct (CBD)...
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Potential clinical utility of intraoperative fluid amylase measurement during pancreaticoduodenectomy

Joshi K, Abradelo M, Bartlett DC, Chatzizacharias N, Dasari BV, Isaac J, Marudanayagam R, Mirza D, Roberts K, Sutcliffe RP

Backgrounds/Aims: Postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy (PD) is a source of major morbidity and mortality. Early diagnosis and treatment of POPF is mandatory to improve patient outcomes and clinical...
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Effects of cancer stigma on quality of life of patients with hepatobiliary and pancreatic cancer

Kim N, Kang D, Shin SH, Heo JS, Shim S, Lim J, Cho J, Han IW

Backgrounds/Aims: Cancer stigma (CS), a self-inflicted sense of hopelessness, has been identified as a major factor affecting cancer patients’ outcomes. However, few studies have investigated the CS-related outcomes in hepatobiliary...
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The Pringle maneuver in the modern era: A review of techniques for hepatic inflow occlusion in minimally invasive liver resection

Mownah OA, Aroori S

During minimally invasive liver resection (MILR), the Pringle maneuver aims to minimize blood loss and provide a clear operative field, thereby identifying intrahepatic structures and facilitating safe parenchymal transection. Several...
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IPMN-LEARN: A linear support vector machine learning model for predicting low-grade intraductal papillary mucinous neoplasms

Hernandez-Barco YG, Daye D, Fernandez-del Castillo CF, Parker RF, Casey BW, Warshaw AL, Ferrone CR, Lillemoe KD, Qadan M

Backgrounds/Aims: We aimed to build a machine learning tool to help predict low-grade intraductal papillary mucinous neoplasms (IPMNs) in order to avoid unnecessary surgical resection. IPMNs are precursors to pancreatic...
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Survival analysis of extrahepatic cholangiocarcinoma based on surveillance, epidemiology, and end results database

Ali H, Zweigle J, Patel P, Tedder B, Khan R, Agrawal S

Backgrounds/Aims: Cholangiocarcinoma (CCA) can be classified as intrahepatic CCA or extrahepatic CCA (eCCA). We intended to analyze and reports the survival outcomes for eCCA. Methods: Surveillance, epidemiology, and end results (SEER)...
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Preoperative neutrophil-to-lymphocyte ratio is prognostic for early recurrence after curative intrahepatic cholangiocarcinoma resection

Choi WJ, Perez FM, Gravely A, Ivanics T, Claasen MPAW, Abraham L, Abreu P, Visser R, Gallinger S, Hansen BE, Sapisochin G

Backgrounds/Aims: Within two years of surgery, 70% of resected intrahepatic cholangiocarcinoma (iCCA) recur. Better biomarkers are needed to identify those at risk of “early recurrence” (ER). In this study, we...
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