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Implantable Devices for Sustained, Intravesical Drug Delivery

Lee SH, Choy YB

In clinical settings, intravesical instillation of a drug bolus is often performed for the treatment of bladder diseases. However, it requires repeated instillations to extend drug efficacy, which may result...
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Efficacy of Paclitaxel-Loaded Bioadhesive Drug Deliver System Based on Glyceryl Monooleate Nanoparticle in an Orthotopic Murine Bladder Cancer Model

Lee SJ, Chung CE, Kim SW, Lee CB, Kang SH, Cho YH, Yoon MS

  • KMID: 2293513
  • Korean J Urol.
  • 2004 Aug;45(8):817-822.
Purpose: The purpose of this study was to evaluate the efficacy of paclitaxel-loaded glyceryl monooleate (GMO) in the intravesical treatment of superficial transitional cell carcinomas of the bladder by enhancing...
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Anticancer Activity of Intravesical Glyceryl Monooleate (GMO)-Paclitaxel Therapy in Murine Superficial Transitional Cell Carcinoma Model Induced by BBN

Choe HS, Kim SW, Cho YH

Purpose: Paclitaxel, on systemic administration, is widely known to be effective in the treatment of bladder cancer. However, the intravesical use of paclitaxel has not been attempted because of its...
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Intravesical PGE2 Administration in Conscious Rats as an Experimental Model of Detrusor Overactivity Observed by Simultaneous Registrations of Intravesical and Intraabdominal Pressures

Jin LH, Han JU, Park CS, Shin HY, Yoon SM, Lee T

  • KMID: 2232749
  • Int Neurourol J.
  • 2010 Aug;14(2):69-77.
PURPOSE: The urodynamic effects of intravesical PGE2 instillation on bladder function and detrusor overactivity (DO) during the filling phase were investigated in rats by measuring intraabdominal and intravesical pressures simultaneously. MATERIALS...
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Early Experience of Intravesical Instillation of Resiniferatoxin (RTX) for Treatment of Detrusor Hyperreflexia in Patients with Spinal Core Injury: Refractoryto Previous Oxybutynin Therapy

Lim YS, Kim HG, Park WH, Park BJ, Kim DY, Lee JK, Shim HB

  • KMID: 1583011
  • Korean J Urol.
  • 2000 Apr;41(4):532-537.
No abstract available.
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Effect of Intraperitoneal and Intravesical Bacillus Calmette-Guerin on Bladder Carcinogenesis in Rats Induced by N-butyl-N-(4-hydroxybutyl) nitrosamine

Kim KM, Kim YK

  • KMID: 2036912
  • Korean J Urol.
  • 1988 Jun;29(3):351-365.
The effects of intraperitoneal injection and intravesical instillation of viable Bacillus Calmette-Guerin(BCG) as an inhibitor in the development of experimental bladder tumors, were examined in rats administered with N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN)....
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Initial Experience of Photodynamic Therapy with Intravesical Instillation of 5-aminolevulinic Acid for Superficial Bladder Cancer

Lee HM, Lee SH, Lee YS, Kim JS, Kim KH, Lee KH, Ahn HJ, Cho DS

  • KMID: 1646786
  • Korean J Urol.
  • 2000 Jun;41(6):713-717.
No abstract available.
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Bioadhesive Drug Delivery System for the Intravesical Administration of Paclitaxel in Rabbits

Lee SJ, Kim SW, Lee CB, Kang SH, Cho YH, Yoon MS

  • KMID: 1914753
  • Korean J Urol.
  • 2004 Apr;45(4):373-379.
PURPOSE: Many reports have shown that the efficacy of intravesical therapy for bladder cancer is, in part, limited by the poor penetration of drugs into the urothelium. The present study...
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Production of tumor necrosis factor by intravesical administration of bacillus Calmette Guerin in patients with superficial bladder cancer

Kim CI, Shin JS, Kim HI, Lee JM, Kim SJ

Although an immune response to bacillus Calmette Guerin (BCG) has often been associated with antitumor activity, the action mechanism(s) of intravesical BCG therapy for prophylaxis and treatment of superficial bladder...
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The Effect of Oral Prednisolone on Pseudo-tumor following Bacillus Calmette Guerin Intravesical Instillation

Park KK, Bang WJ, Seo JW, Kim YS, Lee SY, Ko WJ

Herein, the case of a patient where a pseudo-tumor on the bladder wall, with irritable bladder symptoms following a Bacillus Calmette Guerin (BCG) intravesical instillation, was treated by prednisolone administration...
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The Use of Permeability of Potassium in the Diagnosis of Interstitial Cystitis

Kang TW, Kim DW, Yoon JH, Kwon HY

PURPOSE: The Aim of this study was to find the value of intravesical permeability of potassium as a diagnostic measure of the interstitial cystitis and to find importance of intravesical...
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The Efficacy of Intravesical Irrigation with Distilled Water After Transurethral Resection for Superficial Bladder Tumor

Cho WY, Yoon JB

  • KMID: 1662208
  • Korean J Urol.
  • 1995 Apr;36(4):401-405.
We evaluated the prophylactic efficacy of intravesical irrigation with distilled water immediately after transurethral resection(IUR) of superficial bladder tumor patients. Control group(n=30), with normal saline irrigation immediately after TUR(=15 min.)...
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Effects of intravesical capsaicin on the substance P- and CGRP-immunoreactive terminals of the rat spinal dorsal horn

Yoon H, Lee WT, Park KA

  • KMID: 2040094
  • Korean J Anat.
  • 1999 Aug;32(4):497-507.
Visceral afferent nerve fibers containing substance P or calcitonin gene-related peptide (CGRP) are distributed in the bladder wall, and are known to be stimulated by and then desensitized by capsaicin....
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Intravesical OnabotulinumtoxinA Injection for Overactive Orthotopic Ileal Neobladder: Feasibility and Efficacy

Hoag N, Tse V, Wang A, Chung E, Gani J

The efficacy of intravesical onabotulinumtoxinA (BTXA) in the treatment of overactive bladder (OAB) has been well documented. The use of BTXA injection in orthotopic neobladders is yet to be studied....
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Effects of Combination Treatment of Intravesical Resiniferatoxin Instillation and Hydrodistention in Patients with Refractory Painful Bladder Syndrome/Interstitial Cystitis: A Pilot Study

Ham BK, Kim JH, Oh MM, Lee JG, Bae JH

  • KMID: 2173004
  • Int Neurourol J.
  • 2012 Mar;16(1):41-46.
PURPOSE: Painful bladder syndrome/interstitial cystitis (PBS/IC) is a disabling disease of the urinary bladder, and its etiology and treatment are not yet established. Current medications used in the treatment of...
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Hemorrhagic Cystitis due to Intravesical Instillation of Gentian Violet Completely Recovered with Conservative Therapy

Kim SJ, Koh DH, Park JS, Ahn HS, Choi JB, Kim YS

Chemical cystitis due to intravesical instillation of gentian violet or crystal violet is rare and all of the reported cases have been in adults using undiluted solution, which resulted in...
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Bacillus Calmette-Guerin Instillation As A Prophylactic Treatment of Superficial Bladder Tumor

Park M, Lee C

  • KMID: 2139590
  • Korean J Urol.
  • 1990 Feb;31(1):52-58.
A study was performed to determine the prophylactic efficacy of intravesical BCG instillation in 35 patients with recurrent (more than 3), multiple (more than 3) or large (more than 3cm.)...
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Effects of intravesical oxybutynin instillation on rat voiding cycle

Oh SJ, Choo MS, Kim SW

  • KMID: 2139486
  • Korean J Urol.
  • 1993 Apr;34(2):198-206.
A new cystometic procedure that involves a nonstop transvesical infusion of saline followed by repetitive voiding cycles with emission of infused saline in urethane-anesthetized rats was described by Maggi in...
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Evaluation of T-subsets and NK cell activity in patients with superficial bladder cancer after intravesical treatment with bacillus calmette-guerin

Lee SC, Lee JH, Chang SG, Chai SE

  • KMID: 2036823
  • Korean J Urol.
  • 1992 Apr;33(2):200-205.
Intravesical instillation of Bacillus Calmette-Guerin(BCG) currently is considered the most effective treatment for recurrent superficial bladder cancer, but little is known about the mechanism of action. Total 21 patients receiving...
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The Effects of Intravesical Oxybutynin Chloride in Spinal Cord Injury Patients Who Had Clinical Problems on Oral Medication

Lee IE, Choi HC, Park WH

  • KMID: 1913998
  • Korean J Urol.
  • 1995 Mar;36(3):306-310.
Oxybutynin chloride was administered intravesically in 7 spinal cord injury patients with persistent incontinence and frequent side effects on oral medication. Five mg tablets were dissolved in 20 ml normal...
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