Int Neurourol J.  2016 Mar;20(1):81-85. 10.5213/inj.1630380.190.

Intravesical OnabotulinumtoxinA Injection for Overactive Orthotopic Ileal Neobladder: Feasibility and Efficacy

• Hoag N
• Tse V
• Wang A
• Chung E
• Gani J

• KMID: 2173132
• DOI: http://doi.org/10.5213/inj.1630380.190

Abstract

The efficacy of intravesical onabotulinumtoxinA (BTXA) in the treatment of overactive bladder (OAB) has been well documented. The use of BTXA injection in orthotopic neobladders is yet to be studied. We present 4 cases of patients injected with intravesical BTXA for overactive orthotopic ileal neobladder. We recorded patient demographics, presenting and follow-up symptoms, urodynamic profiles, and Patient Global Impression of Improvement (PGI-I) scores. The 4 patients reported varying degrees of subjective improvements in the symptoms, including urgency, urge incontinence, and pad usage. Mean follow-up duration was 8.3 months (range, 5-14 months). Average PGI-I score was 3 ("a little better") (range, 2-4). To our knowledge, the current study is the first case series examining BTXA injection for orthotopic neobladder overactivity. BTXA injection yielded varying degrees of objective and subjective improvements, without significant complications. Intravesical BTXA injection is feasible and may be considered as a potential treatment alternative for OAB in orthotopic neobladders, although further study is warranted.

Keyword

Administration, Intravesical; OnabotulinumtoxinA; Urinary Reservoirs, Continent; Urinary Bladder, Overactive; Urinary Diversion

MeSH Terms

Administration, Intravesical
Demography
Follow-Up Studies
Humans
Urinary Bladder, Overactive
Urinary Diversion
Urinary Incontinence, Urge
Urinary Reservoirs, Continent
Urodynamics