Korean J Urol.  1995 Mar;36(3):306-310.

The Effects of Intravesical Oxybutynin Chloride in Spinal Cord Injury Patients Who Had Clinical Problems on Oral Medication

Affiliations
  • 1Department of Urology, Korea Veterans Hospital, Seoul, Korea.
  • 2Department of Urology, Inha University, College of Medicine, Ongnam, Korea.

Abstract

Oxybutynin chloride was administered intravesically in 7 spinal cord injury patients with persistent incontinence and frequent side effects on oral medication. Five mg tablets were dissolved in 20 ml normal saline, and the solution was instilled twice daily and retained for 30 minutes. All patients reported subjective improvement following treatment and all became totally continent. No side effects were observed. In urodynamic study mean bladder capacity increased from 250 to 400ml(P = 0.005) and mean maximum filling pressure decreased from 25 to 18cmH2O (P = 0.283). In conclusion treatment with intravesical oxybutynin chloride can be effective in spinal cord injury patients who either are unresponsive to or have intolerable side effects on oral medication.

Keyword

Spinal cord injury; Neurogenic bladder; Intravesical instillation; Oxybutynin chloride

MeSH Terms

Administration, Intravesical
Humans
Spinal Cord Injuries*
Spinal Cord*
Tablets
Urinary Bladder
Urinary Bladder, Neurogenic
Urodynamics
Tablets
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