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A Single Arm, Phase II Study of Simvastatin Plus XELOX and Bevacizumab as First-Line Chemotherapy in Metastatic Colorectal Cancer Patients

Kim Y, Kim TW, Han SW, Ahn JB, Kim ST, Lee J, Park JO, Park YS, Lim HY, Kang WK

PURPOSE: Simvastatin has demonstrated anti-tumor activity in preclinical studies via tumor cell senescence, apoptosis, and anti-angiogenesis. This phase II trial evaluated the efficacy and toxicity profile of conventional XELOX and...
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Comparison of pharmacokinetic characteristics of two Tegoprazan (CJ-12420) formulations in healthy male subjects

Hwang JG, Yoo H, Lee JW, Song GS, Lee S, Kim MG

Proton-pump inhibitors (PPIs) are effectively used to treat acid-related diseases, including gastroesophageal reflux disease (GERD); however, many unmet medical needs still exist. As a new treatment option, potassium-competitive acid blockers...
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Elevation of Procalcitonin in an Adolescent Acetaminophen Intoxication

Kim SE, Lee JB, Jin YH, Yoon JC, Jo SO, Jeong TO

Procalcitonin (PCT) is commonly employed in medical practice as a diagnostic biomarker of bacterial infection and also as a monitoring biomarker for antimicrobial therapy. There have been a few published...
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The use of mobile computing devices in microsurgery

Pafitanis , Hadjiandreou M, Miller R, Mason K, Theodorakopoulou E, Sadri A, Taylor K, Myers S

Mobile computing devices (MCDs), such as smartphones and tablets, are revolutionizing medical practice. These devices are almost universally available and offer a multitude of capabilities, including online features, streaming capabilities,...
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The impacts of three-dimensional anatomical atlas on learning anatomy

Park S, Kim Y, Park S, Shin JA

Gross anatomy has traditionally been the foundation of medical education. Medical students have learned the structure of the human body through dissection, lecture, and textbooks. As tablets and three-dimensional (3D)...
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Comparative Analysis of Prescription for Splitted Tablet using the HIRA-NPS (Health Insurance Review & Assessment Service-National Patient Sample)

Kwon HJ, Jang KW, Ha D

OBJECTIVE: The aim of this study was to analyze the status of split tablet prescription in South Korea. METHODS: We conducted this analysis using 2016 National Patient Sample data from the...
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Effect of Commercial Effervescent Vitamin Tablets on Bovine Enamel

Jeong MJ, Lee MH, Jeong SJ, Kim SJ, Ko MJ, Sim HW, Lee JY, Im AJ, Lim DS

BACKGROUND: In this study, four types of effervescent vitamins marketed in Korea were analyzed for their acidity and vitamin content. For this purpose, bovine teeth were immersed in vitamin, and...
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Characteristics of poisoning in younger children according to different forms of the drugs

Jang M, Ko Y, Yang HW, Lee J

PURPOSE: This study aimed to investigate the characteristics of poisoning drug ingested by younger children, and to compare the clinical outcome by drug forms. METHODS: This was a retrospective analysis based...
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Psychotic Symptoms of Hashimoto's Encephalopathy: A Diagnostic Challenge

Savarimuthu MK, Tsheringla S, Mammen P

Hashimoto's encephalopathy (HE) is a rare and underdiagnosed neuropsychiatric illness. We present the case of a 17-year-old girl who was admitted to a tertiary-care psychiatric center with acute onset psychosis...
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Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients

Yagisawa K, Kobayashi , Ozaki R, Okabayashi S, Toyonaga T, Miura M, Hayashida , Saito E, Nakano M, Matsubara , Hisamatsu , Hibi T

BACKGROUND/AIMS: Oral mesalazine is an important treatment for ulcerative colitis (UC), and non-adherence to mesalazine increases the risk of relapse. Controlled-release (CR) mesalazine has 2 formulations: tablets and granules. The...
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Posaconazole for Prophylaxis of Fungal Infection in Pediatric Patients with Acute Myeloid Leukemia undergoing Induction Chemotherapy

Kim SM, Ree YS, Kim JS, Kim SH, Son ES, Lyu CJ

BACKGROUND: Posaconazole is a broad-spectrum triazole antifungal agent and the most recommended prophylactic antifungal agent for patients with acute myeloid leukemia (AML) undergoing induction chemotherapy. In this study, we evaluated...
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Maternal Depression and Children's Screen Overuse

Park S, Chang HY, Park EJ, Yoo H, Jo W, Kim SJ, Shin Y

BACKGROUND: It is known that there are various factors associated with children's screen overuse. The aim of this study was to examine the effect of maternal depression on 2–5-year-old children's...
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The Beneficial Effect of Korean Red Ginseng Extract on Atopic Dermatitis Patients: An 8 Weeks Open, Noncomparative Clinical Study

Kim H, Park CW, Cho SH

BACKGROUND: Atopic dermatitis (AD) is a chronic or chronically relapsing, eczematous, severely pruritic inflammatory skin disorder. Korean red ginseng (KRG) has been shown previously to exhibit diverse biological effects including...
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Effect of preoperative pregabalin on postoperative pain after gastrectomy

Park CY, Park SH, Lim DG, Choi EK

BACKGROUND: Pregabalin has been studied as a single or multimodal analgesic drug for postoperative pain management in different types of surgeries. We evaluated the analgesic effect of 150 mg of...
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Initial titration with 200 μg fentanyl buccal tablets: a retrospective safety analysis in Korean cancer patients

Kwon MY, Cho HN, Koo DH, Lee YG, Oh S, Lee SS

BACKGROUND/AIMS: Managing breakthrough pain (BTP) is important for many cancer patients because of the rapid onset and unpredictable nature of the pain episodes. Fentanyl buccal tablets (FBTs) are a rapid-onset...
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Pharmacokinetics of fixed-dose combination of rosuvastatin 20 mg and ezetimibe 10 mg compared to concurrent administration of individual tablets in healthy Korean subjects

Hwang I, Park SI, Lee S, Lee B, Yu KS, Jeon JY, Kim MG

This study aimed to compare the pharmacokinetics of fixed-dose combination (FDC) tablet of rosuvastatin 20 mg/ezetimibe 10 mg with that of concurrent administration of individual rosuvastatin 20 mg tablet and...
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Albendazole and Praziquantel: Review and Safety Monitoring in Korea

Hong ST

Albendazole (ADZ) and praziquantel (PZQT) have been used as anthelmintics for over 30 years. Worldwide, hundreds of millions tablets are administered to people and livestock every year. ADZ is poorly...
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A Case of a Visual Field Defect with Optical Coherence Tomography Changes after Sildenafil Citrate Overdose

Park HS, Yang JY, Lee J

PURPOSE: A case of a transient visual field defect and a change in spectral-domain optical coherence tomography (SD-OCT) after an overdose of sildenafil citrate is described. CASE SUMMARY: A 67-year-old male...
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Pharmacokinetic Equivalence of the High Dose Strength Fixed-Dose Combination Tablet of Gemigliptin/Metformin Sustained Release (SR) and Individual Component Gemigliptin and Metformin XR Tablets in Healthy Subjects

Cho YS, Lee SH, Lim HS, Bae KS

BACKGROUND: In type 2 diabetes mellitus therapy, fixed-dose combination (FDC) can offer not only benefits in glucose control via the combined use of agents, but also increase patient compliance. The...
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Mortality from aluminum phosphide poisoning in Kermanshah Province, Iran: characteristics and predictive factors

Navabi SM, Navabi J, Aghaei A, Shaahmadi , Heydari R

OBJECTIVES: Aluminum phosphide (ALP), also known in Iran as rice tablets, is one of the most effective rodenticides used to protect stored grain. However, ALP poisoning regularly causes mortality in...
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