J Korean Soc Coloproctol.  1998 Dec;14(4):761-766.

Clinical Effects of Venitol(R) on Complications after Hemorrhoidectomy Prospective Randomized and Placebo-controlled Trial

Abstract

Fifty four patients who received closed hemorrhoidectomy were randomized into two parallel groups and treated with Venitol(R)(a micronized flavonoidic fraction containing diosmin 450 mg and hesperidin 50 mg) (group 1) or placebo (group 2). Venitol(R) was administered at the dosage of three toblets b.i.d. the first four days and two tablets b.i.d following three days. Postoperative analgesia and laxative prescription as well as hospital stay were same in two groups. Though there is no difference of symptoms at D1, improvement of symptoms of complications was greater in group 1 than in group 2 at D18. The clinical severity of postoperative spot-bleeding, pain and anal discharge diminished in both groups but to a greater extent in group 1 (P<0.005). There was no side-effects in using Venitol(R). In summary, Venitol(R) is effective in reducing complications after hemorrhoidectomy.

Keyword

Venitol; Hemorrhoidectomy; Bleeding

MeSH Terms

Analgesia
Diosmin
Hemorrhage
Hemorrhoidectomy*
Hesperidin
Humans
Length of Stay
Prescriptions
Prospective Studies*
Tablets
Diosmin
Hesperidin
Tablets
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