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Benefits of hesperidin in central nervous system disorders: a review

Kim J, Wie MB, Ahn M, Tanaka A, Matsuda H, Shin T

Citrus species contain significant amounts of flavonoids that possess antioxidant activities; furthermore, dietary citrus is not associated with adverse effects or cytotoxicity in healthy individuals. Hesperidin, which is an abundant...
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Hesperidin Attenuates Ultraviolet B-Induced Apoptosis by Mitigating Oxidative Stress in Human Keratinocytes

Hewage SR, Piao MJ, Kang KA, Ryu YS, Han X, Oh MC, Jung U, Kim IG, Hyun JW

Human skin cells undergo pathophysiological processes via generation of reactive oxygen species (ROS) upon excessive exposure to ultraviolet B (UVB) radiation. This study investigated the ability of hesperidin (C28H34O15) to...
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Maximization of Extracted Condition of Pro-angiogenic Components in Citrus unshiu Peels using Dimethyl Sulfoxide

Lee J, Kim M, Kim JH

Aqueous extraction of Citrus unshiu peels (AECUP) is mainly comprised with pro-angiogenichesperidin and narirutin. In this study, we report approaches to increasing the yields of extracted hesperidin and narirutinfrom Citrus...
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Optimization of Extraction Condition of Hesperidin in Citrus unshiu Peels using Response Surface Methodology

Lee J, Park S, Jeong JY, Jo YH, Lee MK

Hesperidin, which is the most abundant flavonoid of Citrus unshiu (Rutaceae), has been reported to possess diverse activities and widely used as functional foods and cosmetics. For the development of...
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Inhibitory Effects of Yuzu and Its Components on Human Platelet Aggregation

Kim TH, Kim HM, Park SW, Jung YS

Our previous study demonstrated that yuzu has an anti-platelet effect in rat blood. In the present study, we examined whether the anti-platelet effect of yuzu can be extended to human...
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The relaxing effect of Poncirus fructus and its flavonoid content on porcine coronary artery

Yu DJ, Jun JH, Kim TJ, Suh DK, Youn DH, Kim TW

Coronary artery disease is a common occurrence in human, and causes enormous social cost. Poncirus fructus (PF), the dried immature fruits of Poncirus trifoliata Rafinesquem, is used in the treatment...
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Pull-out bond strength of a self-adhesive resin cement to NaOCl-treated root dentin: effect of antioxidizing agents

Khoroushi , Kachuei M

  • KMID: 2316878
  • Restor Dent Endod.
  • 2014 May;39(2):95-103.
OBJECTIVES: This study evaluated the effect of three antioxidizing agents on pull-out bond strengths of dentin treated with sodium hypochlorite. MATERIALS AND METHODS: Root canals of 75 single-rooted human teeth were...
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Effect of antioxidants on push-out bond strength of hydrogen peroxide treated glass fiber posts bonded with two types of resin cement

Khoroushi , Mazaheri H, Tarighi P, Samimi P, Khalighinejad N

OBJECTIVES: Hydrogen peroxide (H2O2) surface treatment of fiber posts has been reported to increase bond strength of fiber posts to resin cements. However, residual oxygen radicals might jeopardize the bonding...
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Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin

Kim B, Lee JY, Lee HY, Nam KY, Park J, Lee SM, Kim JE, Lee JD, Hwang JS

  • KMID: 2048304
  • Biomol Ther.
  • 2013 Sep;21(5):343-348.
We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug...
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Hesperetin Stimulates Cholecystokinin Secretion in Enteroendocrine STC-1 Cells

Kim HY, Park M, Kim K, Lee YM, Rhyu MR

  • KMID: 1502513
  • Biomol Ther.
  • 2013 Mar;21(2):121-125.
Hesperetin (3',5,7-trihydroxy 4'-methoxyflavanone) and its glycoside hesperidin (hesperetin 7-rhamnoglucoside) in oranges have been reported to possess pharmacological effects related to anti-obesity. However, hesperetin and hesperidin have not been studied on...
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Assessment of Antioxidant and Phenolic Compound Concentrations as well as Xanthine Oxidase and Tyrosinase Inhibitory Properties of Different Extracts of Pleurotus citrinopileatus Fruiting Bodies

Alam N, Yoon KN, Lee KR, Kim HY, Shin PG, Cheong JC, Yoo YB, Shim MJ, Lee MW, Lee TS

  • KMID: 2312605
  • Mycobiology.
  • 2011 Mar;39(1):12-19.
Cellular damage caused by reactive oxygen species has been implicated in several diseases, thus establishing a significant role for antioxidants in maintaining human health. Acetone, methanol, and hot water extracts...
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Antioxidant Activities and Tyrosinase Inhibitory Effects of Different Extracts from Pleurotus ostreatus Fruiting Bodies

Alam N, Yoon KN, Lee KR, Shin PG, Cheong JC, Yoo YB, Shim JM, Lee MW, Lee UY, Lee TS

  • KMID: 2312593
  • Mycobiology.
  • 2010 Dec;38(4):295-301.
We evaluated the antioxidant activity and tyrosinase inhibitory effects of Pleurotus ostreatus fruiting bodies extracted with acetone, methanol, and hot water. The antioxidant activities were tested against beta-carotene-linoleic acid, reducing...
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Composition of Flavonoids and Antioxidative Activity from Juice of Jeju Native Citrus Fruits during Maturation

Kim YD, Ko WJ, Koh KS, Jeon YJ, Kim SH

This study aims to evaluate the changes of flavonoid contents and antioxidants activity of Jeju native citrus fruits juice according to the harvest date. Flavonoids such as quercatagetin, narirutin, hesperidin...
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Clinical Effects of Venitol(R) on Complications after Hemorrhoidectomy Prospective Randomized and Placebo-controlled Trial

Lee HW, Lee WY, Chun HK

  • KMID: 1835115
  • J Korean Soc Coloproctol.
  • 1998 Dec;14(4):761-766.
Fifty four patients who received closed hemorrhoidectomy were randomized into two parallel groups and treated with Venitol(R)(a micronized flavonoidic fraction containing diosmin 450 mg and hesperidin 50 mg) (group 1)...
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