Anat Cell Biol.  2019 Dec;52(4):369-377. 10.5115/acb.19.119.

Benefits of hesperidin in central nervous system disorders: a review

• Kim J
• Wie MB
• Ahn M
• Tanaka A
• Matsuda H
• Shin T

• KMID: 2466688
• DOI: http://doi.org/10.5115/acb.19.119

Abstract

Citrus species contain significant amounts of flavonoids that possess antioxidant activities; furthermore, dietary citrus is not associated with adverse effects or cytotoxicity in healthy individuals. Hesperidin, which is an abundant flavanone glycoside in the peel of citrus fruits, possesses a variety of biological capabilities that include antioxidant and anti-inflammatory actions. Over the last few decades, many studies have been investigated the biological actions of hesperidin and its aglycone, hesperetin, as well as their underlying mechanisms. Due to the antioxidant effects of hesperidin and its derivatives, the cardioprotective and anti-cancer effects of these compounds have been widely reviewed. Although the biological activities of hesperidin in neurodegenerative diseases have been evaluated, its potential involvement in a variety of central nervous system (CNS) disorders, including autoimmune demyelinating disease, requires further investigation in terms of the underlying mechanisms. Thus, the present review will focus on the potential role of hesperidin in diverse models of CNS neuroinflammation, including experimental autoimmune encephalomyelitis, with special consideration given to its antioxidant and anti-inflammatory effects in neurodegenerative disease models. Additionally, current evidence provides information regarding the nutraceutical use of hesperidin to prevent various CNS disorders.

Keyword

Hesperidin; Neuroinflammation; Antioxidant; Demyelination; Hippocampus

MeSH Terms

Antioxidants
Central Nervous System Diseases*
Central Nervous System*
Citrus
Demyelinating Diseases
Dietary Supplements
Encephalomyelitis, Autoimmune, Experimental
Flavonoids
Hesperidin*
Hippocampus
Neurodegenerative Diseases
Antioxidants
Flavonoids
Hesperidin

Figure

• 

  Fig. 1 Chemical structures of hesperetin and hesperidin.

• 

  Fig. 2 Illustration of hesperidin involvement in models of neuroinflammation. PPAR, peroxisome proliferator-activated receptor; CNS, central nervous system; TNF-α, tumor necrosis factor α; EAE, experimental autoimmune encephalomyelitis.

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