J Korean Neurol Assoc.
2016 Nov;34(5):350-352. 10.17340/jkna.2016.4.10.
Sensory Polyneuropathy Associated with Pyridoxine Overdose
- Affiliations
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- 1Department of Neurology, Jeju National University School of Medicine, Jeju, Korea. neurokang@jejunu.ac.kr
- KMID: 2359447
- DOI: http://doi.org/10.17340/jkna.2016.4.10
Abstract
- Pyridoxine deficiency and excess have both been implicated as causes of peripheral neuropathy. A 74-year-old man presented with paresthesia in both legs that first appeared 2 months previously. A nerve conduction study revealed axonal sensory polyneuropathy. He had consumed 100 milligrams of pyridoxine every day for 1 year, in the form of vitamin tablets. His blood levels of vitamin B6 were markedly elevated to above 250 nmol/L. This case indicates that the consumption of high-dose pyridoxine can cause sensory polyneuropathy.
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