Korean J Urol.  1990 Feb;31(1):52-58.

Bacillus Calmette-Guerin Instillation As A Prophylactic Treatment of Superficial Bladder Tumor

• Park M
• Lee C

Abstract

A study was performed to determine the prophylactic efficacy of intravesical BCG instillation in 35 patients with recurrent (more than 3), multiple (more than 3) or large (more than 3cm.) superficial bladder tumors(stage Ta or T1). Of the patients 20 were treated with 6 weekly intravesical instillations of 120mg. Pasteur strain BCG after transurethral resection and 15 were followed conventionally. The recurrence rate was 16.2 per cent in the BCG group and 40.1 per cent in the controls during the first 3 months, and it was 39.6 and 92.6 per cent, respectively during l2 months (p<0.005, logrank),Recurrence per 100 patient-months were 5.13 and 11.68, respectively (p<0.00l,chi-square). One patient in the BCG group and 3 controls had recurrent tumors with progression in stage. We conclude from these observations that intravesical BCG instillation is effective in the prophylaxis of tumor recurrence in patients at high risk.

Keyword

BCG; bladder tumor; treatment

MeSH Terms

Administration, Intravesical
Bacillus*
Humans
Mycobacterium bovis
Recurrence
Urinary Bladder Neoplasms*
Urinary Bladder*