Korean J Urol.  2007 Apr;48(4):467-469. 10.4111/kju.2007.48.4.467.

The Effect of Oral Prednisolone on Pseudo-tumor following Bacillus Calmette Guerin Intravesical Instillation

Affiliations
  • 1Department of Urology, National Health Insurance Corporation Ilsan Hospital, Yonsei University College of Medicine, Goyang, Korea. kowj00@hanmail.net
  • 2Department of Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Abstract

Herein, the case of a patient where a pseudo-tumor on the bladder wall, with irritable bladder symptoms following a Bacillus Calmette Guerin (BCG) intravesical instillation, was treated by prednisolone administration is reported. A 40-year-old female underwent a transurethral resection for a bladder carcinoma, with subsequent BCG intravesical instillation. After the final BCG intravesical instillation, the patient presented with lower urinary tract symptoms. A mass on the lateral wall of the bladder, reported as a granuloma formation, was treated with oral prednisolone, after which the symptoms and cystoscopic finding were dramatically improved. Finally, all bladder lesions and irritable bladder symptoms disappeared.

Keyword

Bladder tumor; Bacillus Calmette-Guerin; Cystitis, Prednisolone

MeSH Terms

Administration, Intravesical*
Adult
Bacillus*
Female
Granuloma
Humans
Lower Urinary Tract Symptoms
Mycobacterium bovis
Prednisolone*
Urinary Bladder
Urinary Bladder Neoplasms
Prednisolone

Figure

  • Fig. 1 The cystoscopic finding shows diffusely erythematous mucosa of the bladder (pre-treatment).

  • Fig. 2 A 3cm sized protruding mass on the right lateral wall of the bladder (arrow head), with peritumoral wall thickening are found, but any perivesical tumor infiltration is not clear (pre-treatment).

  • Fig. 3 Cystoscopic finding shows normal mucosa of the bladder (post-treatment).

  • Fig. 4 No definitive mass on the bladder or wall thickening are found (post-treatment).


Reference

1. Morales A, Eidinger D, Bruce AW. Intracavitary Bacillus Cal mette-Guerin in the treatment of superficial bladder tumors. J Urol. 1976. 116:180–183.
2. Luftenegger W, Ackermann DK, Futterlieb A, Kraft R, Minder CE, Nadelhaft P, et al. Intravesical versus intravesical plus intradermal bacillus Calmette-Guerin: a prospective radomnized study in patients with recurrent superficial bladder tumors. J Urol. 1996. 155:483–487.
3. Patard JJ, Muscatelli-Groux B, Saint F, Popov Z, Maille P, Abbou C, et al. Evaluation of local immune response after intravesical bacilli Calmette-Guerin treatment for superficial bladder cancer. Br J Urol. 1996. 78:709–714.
4. O'Donnell MA, DeWolf WC. Bacillus Calmette-Guerin immunotherapy for superficial bladder cancer. New prospects for an old warhorse. Surg Oncol Clin N Am. 1995. 4:189–202.
5. Coplen DE, Marcus MD, Myers JA, Ratliff TL, Catalona WJ. Long-term follow up of patients treated with 1 or 2, 6-week courses of intravesical bacillus Calmette-Guerin: analysis of possible predictors of response free of tumor. J Urol. 1990. 144:652–657.
6. Stanley BM. Walsh PC, Retik AB, Vaughan ED, Wein AJ, Kavoussi LR, Novick AC, editors. Management of superficial bladder cancer. Campbell's urology. 2002. 8th ed. Philadelphia: Saunders;2792.
7. Rischmann P, Desgrandchamps F, Malavaud B, Chopin DK. BCG intravesical instillations: recommendations for side-effects management. Eur Urol. 2000. 37:Suppl 1. 33–36.
8. Lamm DL. Complications of bacillus Calmette-Guerin immunotherapy. Urol Clin North Am. 1992. 19:565–572.
9. Kimura K, Matsuura O, Isobe Y, Kamihira O, Kondo A. A case in which severely irritable bladder following intravesical instillation of Bacillus Calmette Guerin was successfully treated by steroid therapy. Nippon Hinyokika Gakkai Zasshi. 2003. 94:574–577.
10. Wittes R, Klotz L, Kosecka U. Severe bacillus Calmette-Guerin cystitis responds to systemic steroids when antituberculous drugs and local steroids fail. J Urol. 1999. 161:1568–1569.
Full Text Links
  • KJU
Actions
Cited
CITED
export Copy
Close
Share
  • Twitter
  • Facebook
Similar articles
Copyright © 2024 by Korean Association of Medical Journal Editors. All rights reserved.     E-mail: koreamed@kamje.or.kr