- High glucose, unsaturated and saturated fatty acids differentially regulate expression of ATP-binding cassette transporters ABCA1 and ABCG1 in human macrophages
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Mauerer R, Ebert S, Langmann T
- KMID: 1109435
- Exp Mol Med.
- 2009 Feb;41(2):126-132.
- doi: 10.3858/emm.2009.41.2.015
The ATP-binding cassette transporters ABCA1 and ABCG1 are highly expressed in macrophage-derived foam cells and promote reverse cholesterol efflux via biogenesis of high-density lipoproteins. The aim of this study was... -
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- A case of Tangier disease with two novel mutations in the ATP-binding cassette transporter A1 gene
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Park HK, Suh SO, Ahn SJ, Jung JO, Park SJ, Kim HJ, Park HD
- KMID: 2142944
- Korean J Med.
- 2010 Feb;78(2):241-246.
Tangier disease (TD) is a rare autosomal recessive disorder of lipoprotein metabolism characterized by extremely low levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein (apo) A-I resulting in accumulation of... -
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- ABCC2 Haplotype is Associated With Antituberculosis Drug-Induced Maculopapular Eruption
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Kim SH, Jee YK, Lee JH, Lee BH, Kim YS, Park JS, Kim SH
- KMID: 2167028
- Allergy Asthma Immunol Res.
- 2012 Nov;4(6):362-366.
- doi: 10.4168/aair.2012.4.6.362
Genetic variants in ATP-binding cassette (ABC) transporter genes are associated with increased susceptibility to adverse drug reactions. We hypothesized that genetic variant ABC transporters (ABCB1 and ABCC2) may be candidate... -
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- Cloning and Iron Transportation of Nucleotide Binding Domain of Cryptosporidium andersoni ATP-Binding Cassette (CaABC) Gene
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Wang JH, Xue XH, Zhou J, Fan CY, Xie QQ, Wang P
- KMID: 2381838
- Korean J Parasitol.
- 2015 Jun;53(3):335-339.
- doi: 10.3347/kjp.2015.53.3.335
Cryptosporidium andersoni ATP-binding cassette (CaABC) is an important membrane protein involved in substrate transport across the membrane. In this research, the nucleotide binding domain (NBD) of CaABC gene was amplified... -
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- Association of R219K Polymorphism in the ABCA1 Gene with Plasma Lipid Levels and Coronary Artery Disease in Koreans
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Ko YG, Cho EY, Park HY, Jang YS, Kim S, Lee JE
- KMID: 1637927
- Korean Circ J.
- 2003 Jan;33(1):44-51.
- doi: 10.4070/kcj.2003.33.1.44
BACKGROUND AND OBJECTIVES: ATP binding cassette (ABCA)1 is known to play a key role in reverse cholesterol transport. The purpose of this study was to investigate the frequency of the... -
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- ABCB1 and BMI1 mRNA expression in patients with chronic myeloid leukemia: impact on imatinib efficacy
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Bedewy AM, Elmaghraby SM, Kandil NS
- KMID: 2451057
- Blood Res.
- 2019 Mar;54(1):57-62.
- doi: 10.5045/br.2019.54.1.57
BACKGROUND: ATP-binding cassette transporters are important in the mechanism of multidrug resistance. ABCB1 displays a high affinity for imatinib. BMI1 is a polycomb group protein thought to be overexpressed in... -
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- Down-regulation of ATP-binding cassette transporter G1 expression by unmethylated CpG oligodeoxynucleotides in RAW 264.7 macrophages
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Seo JM, Lee JY, Ji GE, You JC
- KMID: 1022127
- Exp Mol Med.
- 2011 Sep;43(9):510-516.
- doi: 10.3858/emm.2011.43.9.058
We have investigated the effect of various forms of phosphodiester cytidine-phosphate-guanosine oligodeoxynucleotides (CpG ODNs) on the production of pro-inflammatory cytokines and related genes in RAW 264.7 macrophages. Treatment with the... -
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- Expression and Function of ABC Transporters as Multidrug Resistance Mechansims in Gastric Cancer Cells
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Moon SP, Kim KJ, Min YD, Lee TB, Jung KR, Lee JU, Choi CH
- KMID: 2096248
- J Korean Surg Soc.
- 2005 May;68(5):359-366.
PURPOSE: Multidrug resistance (MDR) is a phenomenon whereby tumor cell acquire resistance to a broad range of structurally and functionally diverse chemotherapeutic drugs. The most widely implicated mechanism of MDR... -
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- Expression and Function of ABC Transporters as Multidrug Resistance Mechansims in Colon Cancer Cells
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Jeong GA, Kim KJ, Min YD, Lee TB, Kang SI, Jung KR, Choi CH
- KMID: 2101388
- J Korean Soc Coloproctol.
- 2005 Jun;21(3):129-137.
PURPOSE: Multidrug resistance (MDR) is a phenomenon whereby tumor cells acquire resistance to a broad range of structurally and functionally diverse chemotherapeutic drugs. The most widely implicated mechanism of MDR... -
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- Transient neonatal diabetes mellitus caused by a de novo ABCC8 gene mutation
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Kong JH, Kim JB
- KMID: 2284372
- Korean J Pediatr.
- 2011 Apr;54(4):179-182.
- doi: 10.3345/kjp.2011.54.4.179
Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes mellitus that presents within the first 6 months of life with remission in infancy or early childhood. TNDM is... -
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- Reverse Cholesterol Transport in Cultured Gallbladder Epithelial Cells
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Lee J, Choi HS
- KMID: 772620
- Korean J Gastroenterol.
- 2004 Mar;43(3):145-152.
Bile is the major route of cholesterol excretion from the body. It is concentrated in the gallbladder, and often results in supersaturation of cholesterol. The high levels of cholesterol in... -
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- 2,3,7,8-Tetrachlorodibenzo-P-Dioxin Induced Cell-Specific Drug Transporters With Acquired Cisplatin Resistance in Cisplatin Sensitive Cancer Cells
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Gotovdorj , Lee E, Lim Y, Cha EJ, Kwon D, Hong E, Kim Y, Oh MY
- KMID: 1794595
- J Korean Med Sci.
- 2014 Sep;29(9):1188-1198.
- doi: 10.3346/jkms.2014.29.9.1188
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce drug transporter genes such as the ATP-binding cassette G member 2 (ABCG2), which contributes to multidrug resistance. We investigated the effect of TCDD pretreatment on drug... -
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- Isolated Cerebellar Variant of Adrenoleukodystrophy with a de novo Adenosine Triphosphate-Binding Cassette D1 (ABCD1) Gene Mutation
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Kang JW, Lee SM, Koo KY, Lee YM, Nam HS, Quan Z, Kang HC
- KMID: 2130847
- Yonsei Med J.
- 2014 Jul;55(4):1157-1160.
- doi: 10.3349/ymj.2014.55.4.1157
X-linked adrenoleukodystrophy (X-ALD) shows a wide range of phenotypic expression, but clinical presentation as an isolated lesion of the cerebellar white matter and dentate nuclei has not been reported. We... -
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- Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice
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Liu HY, Chung CY, Yang WC, Liang CL, Wang CY, Chang CY, Chang CL
- KMID: 1389763
- J Vet Sci.
- 2012 Sep;13(3):245-252.
- doi: 10.4142/jvs.2012.13.3.245
The incidence of diabetes mellitus is increasing among companion animals. This disease has similar characteristics in both humans and animals. Diabetes is frequently identified as an independent risk factor for... -
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- TAP1 and TAP2 Gene Polymorphisms in Korean Patients with Allergic Rhinitis
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Kim KR, Cho SH, Choi SJ, Jeong JH, Lee SH, Park CW, Tae K
- KMID: 1713288
- J Korean Med Sci.
- 2007 Oct;22(5):825-831.
- doi: 10.3346/jkms.2007.22.5.825
Antigen peptides are actively transported across the endoplasmic reticulum by the transporters associated with antigen presentation (TAP). TAP genes polymorphism could influence the selection process that determines which antigen peptides... -
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- Novel insertion mutation of ABCB1 gene in an ivermectin-sensitive Border Collie
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Han JI, Son HW, Park SC, Na KJ
- KMID: 1072184
- J Vet Sci.
- 2010 Dec;11(4):341-344.
- doi: 10.4142/jvs.2010.11.4.341
P-glycoprotein (P-gp) is encoded by the ABCB1 gene and acts as an efflux pump for xenobiotics. In the Border Collie, a nonsense mutation caused by a 4-base pair deletion in... -
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- Interferon-Stimulated Genes Response in Endothelial Cells Following Hantaan Virus Infection
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Kim IW, Hwang JY, Kim SK, Kim JK, Park HS
- KMID: 1785758
- J Korean Med Sci.
- 2007 Dec;22(6):987-992.
- doi: 10.3346/jkms.2007.22.6.987
The regulation mechanism of interferon (IFN) and IFN-stimulated genes is a very complex procedure and is dependent on cell types and virus species. We observed molecular changes related to anti-viral... -
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- Differential Expression of Stem Cell Markers and Vascular Endothelial Growth Factor in Human Retinoblastoma Tissue
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Kim M, Kim JH, Kim JH, Kim DH, Yu YS
- KMID: 1098791
- Korean J Ophthalmol.
- 2010 Feb;24(1):35-39.
- doi: 10.3341/kjo.2010.24.1.35
PURPOSE: To investigate the relationship between vascular endothelial growth factor (VEGF) and the cancer stem cell-vascular niche complex in human retinoblastoma tissue. METHODS: Six human retinoblastoma specimens primarily enucleated for... -
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- Correlation of Ciprofloxacin Resistance with the AdeABC Efflux System in Acinetobacter baumannii Clinical Isolates
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Ardebili A, Lari AR, Talebi M
- KMID: 2129568
- Ann Lab Med.
- 2014 Nov;34(6):433-438.
- doi: 10.3343/alm.2014.34.6.433
BACKGROUND: Acinetobacter baumannii is one of the most important pathogens capable of colonization in burn patients, leading to drug-resistant wound infections. This study evaluated the distribution of the AdeABC efflux... -
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- The Genetically Modified Polysialylated Form of Neural Cell Adhesion Molecule-Positive Cells for Potential Treatment of X-Linked Adrenoleukodystrophy
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Jang J, Kim HS, Kang JW, Kang HC
- KMID: 1776946
- Yonsei Med J.
- 2013 Jan;54(1):246-252.
- doi: 10.3349/ymj.2013.54.1.246
PURPOSE: Cell transplantation of myelin-producing exogenous cells is being extensively explored as a means of remyelinating axons in X-linked adrenoleukodystrophy. We determined whether 3,3',5-Triiodo-L-thyronine (T3) overexpresses the ABCD2 gene in... -
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