- Analysis of the factors affecting the accuracy of detection for single base alterations by oligonucleotide microarray
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Liu S, Li Y, Fu X, Qiu M, Jiang B, Wu H, Li R, Mao Y, Xie Y
- KMID: 755744
- Exp Mol Med.
- 2005 Apr;37(2):71-77.
The oligonucleotide microarray, a high-throughput polymorphism detection technology, holds great promise for the characterization of complex genetic variance. To achieve greater sensitivity and specificity for it to be an effective... -
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- Detection of YMDD Motif Mutants by Oligonucleotide Chips in Lamivudine-Untreated Patients with Chronic Hepatitis B Virus Infection
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Heo J, Cho M, Kim HH, Shin YM, Jang HJ, Park HK, Kim CM, Kim GH, Kang DH, Song GA, Yang US
- KMID: 2157683
- J Korean Med Sci.
- 2004 Aug;19(4):541-546.
- doi: 10.3346/jkms.2004.19.4.541
Lamivudine, a nucleoside analogue, has been used widely as an effective antiviral agent for the treatment of patients with chronic hepatitis B virus (HBV) infection. However, the YMDD motif mutation... -
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- Integrated analysis of copy number alteration and RNA expression profiles of cancer using a high-resolution whole-genome oligonucleotide array
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Jung SH, Shin SH, Yim SH, Choi HS, Lee SH, Chung YJ
- KMID: 1058020
- Exp Mol Med.
- 2009 Jul;41(7):462-470.
- doi: 10.3858/emm.2009.41.7.051
Recently, microarray-based comparative genomic hybridization (array-CGH) has emerged as a very efficient technology with higher resolution for the genome-wide identification of copy number alterations (CNA). Although CNAs are thought to... -
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- Microarray Analysis of Thyroid Stimulating Hormone, Insulin-Like Growth Factor-1, and Insulin-Induced Gene Expression in FRTL-5 Thyroid Cells
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Lee YJ, Park DJ, Shin CS, Park KS, Kim SY, Lee HK, Park YJ, Cho BY
- KMID: 1713298
- J Korean Med Sci.
- 2007 Oct;22(5):883-890.
- doi: 10.3346/jkms.2007.22.5.883
To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the... -
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- Gene Expression Profiling of Breast Cancers with Emphasis of beta-Catenin Regulation
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Roh MS, Hong SH, Jeong JS, Kwon HC, Kim MC, Cho SH, Yoon JH, Hwang TH
- KMID: 1733489
- J Korean Med Sci.
- 2004 Apr;19(2):275-282.
- doi: 10.3346/jkms.2004.19.2.275
To gain molecular understanding of carcinogenesis of breast cancer, gene expression profiles were analyzed using cDNA microarray representing 4,600 cDNAs in 10 breast cancer samples and the adjacent noncancerous breast... -
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- Gene Expression Analysis of Cultured Amniotic Fluid Cell with Down Syndrome by DNA Microarray
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Chung IH, Lee SH, Lee KW, Park SH, Cha KY, Kim NS, Yoo HS, Kim YS, Lee S
- KMID: 1781731
- J Korean Med Sci.
- 2005 Feb;20(1):82-87.
- doi: 10.3346/jkms.2005.20.1.82
Complete or partial triplication of human chromosome 21 results in Down syndrome (DS). To analyze differential gene expressions in amniotic fluid (AF) cells of DS, we used a DNA microarray... -
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- Comparison of the Digene HPV Genotyping LQ Test and the PANArray HPV Genotyping Chip for Detection of High-Risk or Probable High-Risk Human Papillomavirus Genotypes
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Park KS, Kim JY, Ki CS, Lee NY
- KMID: 1791935
- Ann Lab Med.
- 2014 Jul;34(4):279-285.
- doi: 10.3343/alm.2014.34.4.279
BACKGROUND: We evaluated the performance of two different array-based techniques, a bead-based multiplex genotyping method (LQ; digene HPV Genotyping LQ Test, QIAGEN, Germany) and a DNA chip-based method using peptide... -
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- HER-2/neu Oncogene Amplification by Chromogenic in situ Hybridization in 130 Breast Cancers Using Tissue Microarray and Clinical Follow-up Studies
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Chang E, Lee A, Lee E, Lee H, Shin O, Oh S, Kang C
- KMID: 1786817
- J Korean Med Sci.
- 2004 Jun;19(3):390-396.
- doi: 10.3346/jkms.2004.19.3.390
Determining of HER-2/neu oncogene amplification has become clinically important for managing breast cancer. Fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) are currently regarded as the standard methods. Chromogenic in... -
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- Identification of amyloid beta-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid beta-peptide toxicity
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Kim JR, Lee SR, Chung HJ, Kim S, Baek SH, Kim JH, Kim YS
- KMID: 1093613
- Exp Mol Med.
- 2003 Oct;35(5):403-411.
Amyloid beta-peptide (Abeta), a causative molecule in the pathogenesis of Alzheimer's disease and the main component of senile plaques, is known to be neurotoxic in vitro and in vivo. The... -
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- Gene network and canonical pathway analysis in prostate cancer: a microarray study
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Savli H, Szendroi A, Romics I, Nagy B
- KMID: 1052940
- Exp Mol Med.
- 2008 Apr;40(2):176-185.
- doi: 10.3858/emm.2008.40.2.176
The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and... -
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- Microarray Analysis for Genes Associated with Angiogenesis in Diabetic OLETF Keratocytes
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Park JM, Park YM, Jung W, Lee JE, Lee JS
- KMID: 1789986
- J Korean Med Sci.
- 2014 Feb;29(2):265-271.
- doi: 10.3346/jkms.2014.29.2.265
The purpose of this study was to identify the differences in angiogenesis gene expression between normal and diabetic keratocytes stimulated with interleukin-1alpha (IL-1alpha) and tumor necrosis factor-alpha (TNF-alpha). Primarily cultured... -
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- Clinical Significance of Previously Cryptic Copy Number Alterations and Loss of Heterozygosity in Pediatric Acute Myeloid Leukemia and Myelodysplastic Syndrome Determined Using Combined Array Comparative Genomic Hybridization plus Single-Nucleotide Polymorphism Microarray Analyses
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Koh KN, Lee JO, Seo EJ, Lee SW, Suh JK, Im HJ, Seo JJ
- KMID: 1789951
- J Korean Med Sci.
- 2014 Jul;29(7):926-933.
- doi: 10.3346/jkms.2014.29.7.926
The combined array comparative genomic hybridization plus single-nucleotide polymorphism microarray (CGH+SNP microarray) platform can simultaneously detect copy number alterations (CNA) and copy-neutral loss of heterozygosity (LOH). Eighteen children with acute... -
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- A Gene Expression in Study Human Gastric Adenocarcinoma Using a cDNA Microarray
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Lee JH, Choi SR, Hwang TH, Kim MC, Jung GJ, Roh MS, Jeong JS
- KMID: 1066039
- Korean J Gastroenterol.
- 2003 Dec;42(6):484-495.
BACKGROUND/AIMS: cDNA microarray provides a powerful alternative with an unprecedented view scope in monitoring gene expression levels and leads to discoveries of regulatory pathways involved in complicated biological processes.... -
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- Clinical Efficacy of HPV DNA Chip Test in the Era of HPV Vaccination: 1,211 Cases, A Single Institution Study
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Kahng J, Lee HJ
- KMID: 1781561
- Korean J Lab Med.
- 2008 Feb;28(1):70-78.
- doi: 10.3343/kjlm.2008.28.1.70
BACKGROUND: Human papillomavirus (HPV) prophylactic vaccines, bivalent types for HPV-16/18 with 70% prophylactic expectation, have been developed based on the genotypes found prevalent in the western countries, but little is... -
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- Differentiated miRNA expression and validation of signaling pathways in apoE gene knockout mice by cross-verification microarray platform
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Han H, Wang YH, Qu GJ, Sun TT, Li FQ, Jiang W, Luo SS
- KMID: 2154232
- Exp Mol Med.
- 2013 Mar;45(3):e13.
The microRNA (miRNA) regulation mechanisms associated with atherosclerosis are largely undocumented. Specific selection and efficient validation of miRNA regulation pathways involved in atherosclerosis development may be better assessed by contemporary... -
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