Kidney Res Clin Pract.  2024 Sep;43(5):586-599. 10.23876/j.krcp.23.156.

Pathogenesis and management of renal fibrosis induced by unilateral ureteral obstruction

• Nan QY
• Piao SG
• Jin JZ
• Chung BH
• Yang CW
• Li C

• KMID: 2564666
• DOI: http://doi.org/10.23876/j.krcp.23.156

Abstract

Regardless of the underlying etiology, renal fibrosis is the final histological outcome of progressive kidney disease. Unilateral ureteral obstruction (UUO) is an ideal and reproducible experimental rodent model of renal fibrosis, which is characterized by tubulointerstitial inflammatory responses, accumulation of extracellular matrix, tubular dilatation and atrophy, and fibrosis. The magnitude of UUO-induced renal fibrosis is experimentally manipulated by the species chosen, animal age, and the severity and duration of the obstruction, while relief of the obstruction allows the animal to recover from fibrosis. The pathogenesis of renal fibrosis is complex and multifactorial and is orchestrated by activation of renin-angiotensin system (RAS), oxidative stress, inflammatory response, transforming growth factor beta 1-Smad pathway, activated myofibroblasts, cell death (apoptosis, autophagy, ferroptosis, and necroptosis), destruction of intracellular organelles, and signaling pathway. The current therapeutic approaches have limited efficacy. Inhibition of RAS and use of antioxidants and antidiabetic drugs, such as inhibitors of sodium-glucose cotransporter 2 and dipeptidyl peptidase-4, have recently gained attention as therapeutic strategies to prevent renal scarring. This literature review highlights the state of the art regarding the molecular mechanisms relevant to the management of renal fibrosis caused by UUO.

Keyword

Apoptosis; Autophagy; Endoplasmic reticulum stress; Mitochondria; Oxidative stress; Unilateral ureteral obstruction