Clin Psychopharmacol Neurosci.
2024 Nov;22(4):646-654. 10.9758/cpn.24.1189.
The Moderating Effect of Serum Vitamin D on the Relationship between Beta-amyloid Deposition and Neurodegeneration
- Park J
1,2 - Byun MS1,2,3
- Yi D4
- Ahn H5
- Jung JH1,6
- Kong N7
- Chang YY1,8
- Jung G4
- Lee JY1,9
- Kim YK10,11
- Lee YS11
- Kang KM12
- Sohn CH12
- Lee DY1,2,3,4,5
- for the KBASE Research Group
- Affiliations
-
- 1Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
- 2Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea
- 3Convergence Research Center for Dementia, Seoul National University Medical Research Center, Seoul, Korea
- 4Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, Korea
- 5Interdisciplinary Program of Cognitive Science, College of Humanities, Seoul National University, Seoul, Korea
- 6Department of Psychiatry, Chungbuk National University Hospital, Cheongju, Korea
- 7Department of Psychiatry, Keimyung University Dongsan Medical Center, Daegu, Korea
- 8Department of Psychiatry, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea
- 9Department of Neuropsychiatry, SMG-SNU Boramae Medical Center, Seoul, Korea
- 10Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, Korea
- 11Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea
- 12Department of Radiology, Seoul National University Hospital and Seoul National University College of Medicine, Seoul, Korea
- KMID: 2562275
- DOI: http://doi.org/10.9758/cpn.24.1189
Abstract
Objective
Previous studies have reported that vitamin D deficiency increased the risk of Alzheimer’s disease (AD) dementia in older adults. However, little is known about how vitamin D is involved in the pathophysiology of AD. Thus, this study aimed to examine the association and interaction of serum vitamin D levels with in vivo AD pathologies including cerebral beta-amyloid (Aβ) deposition and neurodegeneration in nondemented older adults.
Methods
428 Nondemented older adults were recruited from the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer’s Disease, a prospective cohort that began in 2014. All participants underwent comprehensive clinical assessments, measurement of serum 25-hydroxyvitamin D (25[OH]D), and multimodal brain imaging including Pittsburgh compound B (PiB) positron emission tomography and magnetic resonance imaging. Global PiB deposition was measured for the Aβ biomarker. Intracranial volume-adjusted hippocampal volume (HVa) was used as a neurodegeneration biomarker.
Results
Overall, serum 25(OH)D level was not associated with either Aβ deposition or HVa after controlling for age, sex, apolipoprotein E ε4 positivity, and vascular risk factors. However, serum 25(OH)D level had a significant moderating effect on the association between Aβ and neurodegeneration, with lower serum 25(OH)D level significantly exacerbating cerebral Aβ-associated hippocampal volume loss (B = 34.612, p = 0.008).
Conclusion
Our findings indicate that lower serum vitamin D levels may contribute to AD by exacerbating Aβ-associated neurodegeneration in nondemented older adults. Further studies to explore the potential therapeutic effect of vitamin D supplementation on the progression of AD pathology will be necessary.
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