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Cardiovascular Complications of Acetylcholinesterase Inhibitors in Patients with Alzheimer’s Disease: A Narrative Review

Young S, Chung E, Chen MA

While acetylcholinesterase inhibitors are used to treat a wide range of patients with Alzheimer’s disease, acetylcholinesterase inhibitor use has also been associated with a variety of cardiovascular complications, including bradycardia...
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Novel Biomarkers of Alzheimer’s Disease: Based Upon N-methylD-aspartate Receptor Hypoactivation and Oxidative Stress

Chiang TI, Yu YH, Lin CH, Lane HY

Early detection and prevention of Alzheimer's disease (AD) is important. The current treatment for early AD is acetylcholine esterase inhibitors (AChEIs); however, the efficacy is poor. Besides, AChEI did not...
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Effects of Electrical Automatic Massage on Cognition and Sleep Quality in Alzheimer’s Disease Spectrum Patients: A Randomized Controlled Trial

Kim YJ, Kim HR, Jung YH, Park YH, Seo SW

Purpose: Muscle relaxation following electrical automatic massage (EAM) has been found to reduce fatigue, depression, stress, anxiety, and pain in individuals with various conditions. However, the effects of EAM have...
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Finding the optimal cutoff value for amyloid β positivity using the iterative outlier method and concordance rate

Kim HR, Choe YS, Moon SH, Kim HJ, Jang H, L.Na D, Park S, Seo SW

Purpose: The purpose of this study was to calculate the cutoff value for amyloid β (Aβ) positron emission tomography (PET) positivity using the iterative outlier method and to evaluate its...
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Proton-pump Inhibitors and the Risk of Dementia: A Systematic Review and Meta-analysis

Yoon KT, Bang CS, Kim JS

Background/Aims: Proton pump inhibitors (PPIs) are widely used to treat several acid-related gastrointestinal disorders. This study aimed to investigate the risk of dementia in patients taking PPIs. Materials and Methods: A...
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Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-β-Induced Alzheimer Disease Rats

Kim SH, Ko YJ, Kim JY, Sim YJ

Purpose: Exercise is known to reduce proinflammatory cytokines production and apoptosis. We investigated the effect of treadmill running on spatial learning memory in terms of activation of nuclear factor kappa...
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Pathobiolgy and Management of Alzheimer’s Disease

Kim H, Chung JY

Amyloid and tau protein abnormalities have been identified as the main causes of Alzheimer’s disease but exact mechanisms remain to be revealed. Especially, amyloid beta and tau protein coupling and...
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Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study

Cho Y, Han K, Kim DH, Park YM, Yoon KH, Kim MK, Lee SH

Background: Metabolic disturbances are modifiable risk factors for dementia. Because the status of metabolic syndrome (MetS) and its components changes over time, we aimed to investigate the association of the...
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Comprehensive Visual Rating Scale on Magnetic Resonance Imaging: Application to Prodromal Alzheimer Disease

Chung JK, Jang JW, the Alzheimer’s Disease Neuroimaging Initiative

Background: A comprehensive visual rating scale (CVRS) using brain magnetic resonance imaging (MRI) was previously developed to evaluate structural changes in the brains of older patients. This study investigated the...
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The Long-Term Outcomes of Alzheimer’s Disease Patients Treated with Anti-Dementia Medications According to Baseline Dementia Severity

Seo H, Park Y, Kwon I, Kim JL

  • KMID: 2513153
  • J Korean Soc Biol Ther Psychiatry.
  • 2021 Feb;27(1):33-39.
Objectives:To describe the differences in long-term outcomes in Alzheimer’s disease (AD) patients according to initial dementia severity. Methods:A retrospective chart review of AD patients from a dementia clinic at the University...
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MicroRNAs Related to Cognitive Impairment After Hearing Loss

Mun SK, Chae H, Piao XY, Lee HJ, Kim YK, Oh SH, Chang M

Objectives. Our research group has previously demonstrated that hearing loss might be a risk factor for synaptic loss within the hippocampus and impairment of cognition using an animal model of...
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Decreased Cortical Thickness and Local Gyrification in Individuals with Subjective Cognitive Impairment

Youn H, Choi M, Lee S, Kim D, Suh S, Han CE, Jeong HG

Objective: Subjective cognitive impairment (SCI) is associated with future cognitive decline. This study aimed to compare cortical thickness and local gyrification index (LGI) between individuals with SCI and normal control...
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Association of Antipsychotics and Behavioral and Psychological Symptoms of Dementia With Cognitive Decline in Subjects With Alzheimer’s Disease

Chang JH, Jon D, Hong HJ, Jung MH, Hong N

Objective: Neuropsychiatric symptoms are common among patients with major neurocognitive disorder. Antipsychotic medica-tions have been widely used to manage behavioral and psychological symptoms of dementia (BPSD), however efficacy and safety...
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Analysis of behavioral management for dental treatment in patients with dementia using the Korean National Health Insurance data

Kim T, Chi SI, Kim H, Seo KS

Background: The global population is aging rapidly, and accordingly, the number of patients with dementia is increasing every year. Although the need for dental treatment increases for various reasons in...
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A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups

Kim KW, Na SH, Chung YC, Shin BS

Background and Purpose: Language dysfunction is a symptom common to patients with Alzheimer's disease (AD). Speech feature analysis may be a patient-friendly screening test for early-stage AD. We aimed to...
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Development of donepezil-induced hypokalemia following treatment of cognitive impairment

Kim D, Yoon HE, Park HS, Shin SJ, Choi BS, Kim BS, Ban TH

Donepezil is a cholinesterase inhibitor used extensively to treat Alzheimer disease. The increased cholinergic activity is associated with adverse effects, therefore gastrointestinal symptoms, including nausea, vomiting, and diarrhea, are common....
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History of Coffee Consumption and Risk of Alzheimer's Disease: a Meta-epidemiological Study of Population-based Cohort Studies

Bae JM

Background and Purpose: Four published quantitative systematic reviews showed conflicting results involving coffee consumption and the risk of Alzheimer's disease (AD). The aim of this meta-epidemiological meta-analysis (MEMA) was to...
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Medial Temporal Atrophy Alone is Insufficient to Predict Underlying Alzheimer’s Disease Pathology

Jeong HE, Shin DH, Lee DC

Background: The medial temporal region is the earliest affected structure in patients with Alzheimer’s disease (AD), and its atrophy is known as the hallmark of AD. This study aimed to...
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An Autopsy-Proven Case of Limbic-Predominant Age-Related TDP-43 Encephalopathy

Cho SH, Choi SM, Kim BC, Song WY, Kim HS, Lee KH

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently established neurodegenerative disease entity. LATE neuropathological change (LATE-NC) is characterized by a TDP-43 proteinopathy that mainly involves the amygdala and medial temporal...
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Survival Analysis of Patients with Alzheimer’s Disease: A Study Based on Data from the Korean National Health Insurance Services’ Senior Cohort Database

Huh TH, Yoon JL, Cho JJ, Kim MY, Ju YS

Background: Korea’s rapidly aging population has experienced a sharp rise in the prevalence of dementia. Patients with Alzheimer’s disease (AD), which is estimated to be about three-quarters of all patients...
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