Allergy Asthma Respir Dis.
2023 Jul;11(3):117-125. 10.4168/aard.2023.11.3.117.
KAAACI Allergic Rhinitis Guidelines: Part 1. Update in pharmacotherapy
- Kim M1
- Kang SY2
- Yang SI3
- Lee IH4
- Ryu G
5 - Kim MA6
- Lee SM2
- Kim HJ7
- Park DY8
- Lee YJ9
- Kim DK4,10
- Kim DH11
- Jun YJ12
- Park SC13
- Kim BS14
- Chung S15,16
- Lee HJ17
- Kim HB18
- Choi JH15,16
- Choi GS19
- Yang HJ20
- Kim SW11
- Affiliations
-
- 1Department of Pediatrics, Chungnam National University Sejong Hospital, Sejong, Korea
- 2Division of Pulmonology and Allergy, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea
- 3Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea
- 4Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea
- 5Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
- 6Department of Pulmonology, Allergy and Critical Care Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea
- 7Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea
- 8Department of Otolaryngology, Ajou University School of Medicine, Suwon, Korea
- 9Department of Pediatrics, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Korea
- 10Institute of New Frontier Research, Division of Big Data and Artificial Intelligence, Hallym University College of Medicine, Chuncheon, Korea
- 11Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea
- 12Department of Otorhinolaryngology-Head and Neck surgery, Uijeongbu Eulji Medical Center, Eulji University, Uijeongbu, Korea
- 13Department of Otorhinolaryngology-Head and Neck surgery, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea
- 14Department of Pediatrics, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea
- 15Department of Pulmonology and Allergy, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea
- 16Allergy and Clinical Immunology Research Center, Hallym University College of Medicine, Chuncheon, Korea
- 17Lee and Hong ENT Sleep and Cosmetic Center, Seongnam, Korea
- 18Department of Pediatrics, Asthma and Allergy Center, Inje University Sanggye Paik Hospital, Seoul, Korea
- 19Division of Allergy, Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea
- 20Pediatric Allergy and Respiratory Center, Department of Pediatrics, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Korea
- KMID: 2545006
- DOI: http://doi.org/10.4168/aard.2023.11.3.117
Abstract
- The prevalence of allergic rhinitis (AR) and the socioeconomic burden associated with the medical cost and quality of life of AR have progressively increased. Therefore, practical guidelines for the appropriate management of AR need to be developed based on scientific evidence considering the real-world environment, values, and preferences of patients and physicians. The Korean Academy of Asthma, Allergy and Clinical Immunology revised clinical guidelines for AR to address key clinical questions of the management of AR. Part 1 of the revised guideline covers the pharmacological management of patients with AR in Korea. Through a meta-analysis and a systematic review, we made 4 recommendations for AR pharmacotherapy, including intranasal corticosteroid (INCS)/intranasal antihistamine combination therapy, oral antihistamine/INCS combination therapy, leukotriene receptor antagonist treatment in AR patients with asthma, and prophylactic treatment for patients with pollen-induced AR. However, all recommendations are conditional because of the low or very low evidence of certainty. Well-designed and strictly executed randomized controlled trials are needed to measure and report appropriate outcomes.
