Immune Netw.
2022 Feb;22(1):e13. 10.4110/in.2022.22.e13.
The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease
- Affiliations
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- 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
- KMID: 2536231
- DOI: http://doi.org/10.4110/in.2022.22.e13
Abstract
- Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to pro-inflammatory, which promotes low grade systemic inflammation and insulin resistance in obese mice. Various T cell subsets either help maintain metabolic homeostasis in healthy states or contribute to obesity-associated metabolic syndromes. In this review, we will discuss the T cell subsets that reside in adipose tissue and intestines and their role in the development of obesity-induced systemic inflammation.
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