Korean J Obes.  2014 Jun;23(2):83-90.

Inflammatory Receptors/Ligands as a Novel Target Against Obesity-Induced Inflammation and Metabolic Diseases

• Yu R

Abstract

Obesity-induced inflammation is considered to be a potential cause of metabolic disorders such as insulin resistance, type 2 diabetes, and cardiovascular diseases. Various inflammatory components involved in obesity-induced inflammation are known, but the biomolecules and mechanisms underlying the obesity-related inflammation/metabolic diseases remain to be elucidated. Cell surface membrane receptors TNFRSFs (Tumor Necrosis Factor Receptor Superfamily) and their counterpart ligands provide important inflammatory signals through their interaction, and thus have been exploited for therapeutic targets for treating various inflammatory diseases. Recent studies demonstrate that some of the inflammatory receptors/ligands are associated with obesity-induced inflammation and metabolic diseases. In this mini-review, the role of four different inflammatory receptors/ligand (CD40/CD40L, 4-1BB/4-BBL, FN14/TWEAK, HEVM/LIGHT) interactions are discussed along with their potential for therapeutic targets against obesity-related inflammation and metabolic diseases.

Keyword

Obesity; Inflammation; Metabolic diseases; Inflammatory receptor/ligand

MeSH Terms

Cardiovascular Diseases
Inflammation*
Insulin Resistance
Ligands
Membranes
Metabolic Diseases*
Necrosis
Obesity
Ligands